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Novel Modulators in Nociception

  • Chapter
The Pharmacology of Pain

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 130))

Abstract

As novel modulators in nociception, the three messengers discussed in this chapter — one gas (nitric oxide) and two peptides (cholecystokinin and galanin) — have a number of characteristics in common. First, the presence of these messengers in the nervous system has been discovered only in the past one or two decades. Second, their roles in nociceptive transmission and modulation have been extensively studied only in recent years. Third, the expression of all three substances becomes greatly increased in sensory neurons after peripheral nerve injury. There is ample evidence that nerve injury or inflammation induces dramatic morphological and functional plasticity in the nervous system, and such plasticity plays a vital part in the development of chronic pain states known to be associated with these pathological states (Willis 1994; Hökfelt et al. 1994). Thus because of the apparent involvement of these messengers in neuronal plasticity they may be important targets for the development of novel analgesics.

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Authors
  1. X.-J. Xu
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  2. Z. Wiesenfeld-Hallin
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Editors and Affiliations

  1. Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK

    A. Dickenson

  2. Physiopharmacologie du Système Nerveux et Laboratioire de Physiopharmacologie de la Douluer (EPHE), INSERM, U.161, 2, rue d’Alésia, F-75014, Paris, France

    J.-M. Besson

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© 1997 Springer-Verlag Berlin Heidelberg

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Xu, XJ., Wiesenfeld-Hallin, Z. (1997). Novel Modulators in Nociception. In: Dickenson, A., Besson, JM. (eds) The Pharmacology of Pain. Handbook of Experimental Pharmacology, vol 130. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60777-6_9

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  • DOI: https://doi.org/10.1007/978-3-642-60777-6_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64550-1

  • Online ISBN: 978-3-642-60777-6

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