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Animal Models of Analgesia

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The Pharmacology of Pain

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 130))

Abstract

Measurement of pain and analgesia in animals poses a variety of problems. In addition to the fact that pain itself constitutes a multiplicity of sensory entities, the term pain is poorly defined in relationship to animals and animal behaviour.

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References

  • Aanonsen LM, Wilcox GL (1987) Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered Opioids, phencyclidine and sigma-agonists. J Pharmacol Exp Ther 243:9–19

    PubMed  CAS  Google Scholar 

  • Ahlgren SC, Levine JD (1994) Protein kinase C inhibitors decrease hyperalgesia and C-fiber hyperexcitability in the streptozotocin-diabetic rat. J Neurophysiol 72:684–692

    PubMed  CAS  Google Scholar 

  • Ahlgren SC, Levine JD (1993) Mechanical hyperalgesia in streptozotocin-diabetic rats. Neuroscience 52:1049–1055

    Article  PubMed  CAS  Google Scholar 

  • Ahlgren SC, White DM, Levine JD (1992) Increased responsiveness of sensory neurons in the saphenous nerve of the streptozotocin-diabetic rat. J Neurophysiol 68:20772085

    Google Scholar 

  • Attal N, Jazat F, Kayser V, Guilbaud G (1990) Further evidence for “pain-related” behaviours in a model of unilateral peripheral mononeuropathy. Pain 41:235–251

    Article  PubMed  CAS  Google Scholar 

  • Bennett GJ (1993) An animal model of neuropathic pain: a review. Muscle Nerve 16:1040–1048

    Article  PubMed  CAS  Google Scholar 

  • Bennett GJ, Xie YK (1988) A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33:87–107

    Article  PubMed  CAS  Google Scholar 

  • Berge OG, Garcia-Cabrera I, Hole K (1988) Response latencies in the tail-flick test depend on tail skin temperature. Neurosci Lett 86:284–288

    Article  PubMed  CAS  Google Scholar 

  • Besse D, Weil-Fugazza J, Lombard MC, Butler SH, Besson JM (1992) Monoarthritis induces complex changes in mu-opioid, delta-opioid and kappa-opioid binding sites in the superficial dorsal horn of the rat spinal cord. Eur J Pharmacol 223:123–131

    Article  PubMed  CAS  Google Scholar 

  • Besson JM, Guilbaud G (1988) The arthritic rat as a model of clinical pain? Excerpta Medica, Amsterdam

    Google Scholar 

  • Blumenkopf B, Lipman JJ (1991) Studies in autotomy: its pathophysiology and usefulness as a model of chronic pain. Pain 45:203–209

    Article  PubMed  CAS  Google Scholar 

  • Brandt KD, Braunstein EM, Visco DM, O’Connor B, Heck D, Albrecht M (1991) Anterior (cranial) cruciate ligament transection in the dog: a bona fide model of Osteoarthritis, not merely of cartilage injury and repair. J Rheumatol 18:436–446

    PubMed  CAS  Google Scholar 

  • Brown DM, Hughes BO (1962) Practical aspects of strain variation in relation to pharmacological testing. Pharmacol Pharmacol 14:399–405

    CAS  Google Scholar 

  • Butler SH, Godefroy F, Besson J, Weil-Fugazza J (1992) A limited arthritic model for chronic pain studies in the rat. Pain 48:73–81

    Article  PubMed  CAS  Google Scholar 

  • Carlton SM, Lekan HA, Kim SH, Chung JM (1994) Behavioral manifestations of an experimental model for peripheral neuropathy produced by spinal nerve ligation in the primate. Pain 56:155–166

    Article  PubMed  CAS  Google Scholar 

  • Carr KD, Aleman DO, Holland MJ, Simon EJ (1984) Analgesic effects of ethylketocyclazocine and morphine in rat and toad. Life Sci 35:997–1003

    Article  PubMed  CAS  Google Scholar 

  • Chapman CR, Casey KL, Dubner R, Foley KM, Gracely, Reading AE (1985) Pain measurement: an overview. Pain 22:1–31

    Article  PubMed  CAS  Google Scholar 

  • Chernov HI, Wilson DE, Fowler F, Plummer AJ (1967) Non-specificity of the mouse writhing test. Arch Int Pharmacodyn 167:171–178

    PubMed  CAS  Google Scholar 

  • Coderre TJ, Wall PD (1987) Ankle joint urate arthritis (AJUA) in rats: an alternative model of arthritis to that produced by Freund’s adjuvant. Pain 28:379

    Article  PubMed  CAS  Google Scholar 

  • Coderre TJ, Vaccarino TJ, Melzack R (1990) Central nervous system plasticity in the tonic pain response to subcutaneous formalin injection. Brain Res 535:155–158

    Article  PubMed  CAS  Google Scholar 

  • Costa M, Sutter P, Gybels J, Hees J (1981) Adjuvant-induced arthritis in rats: a possible animal model of chronic pain. Pain 10:173–185

    Article  Google Scholar 

  • Courteix C, Eschalier A, Lavarenne J (1993) Streptozocin-induced diabetic rats: behavioural evidence for a model of chronic pain. Pain 53:81–88

    Article  PubMed  CAS  Google Scholar 

  • Courteix C, Bradin M, Chantelauze C, Lavarenne J, Eschalier A (1994) Study of the sensitivity of the diabetes induced pain model in rats to a range of analgesics. Pain 57:153–160

    Article  PubMed  CAS  Google Scholar 

  • D’Amour FE, Smith DL (1941) A method for determing loss of pain sensation. J Pharmacol 72:74–79

    Google Scholar 

  • DeLeo JA, Coombs DW (1991) Autotomy and decreased spinal substance P following peripheral cryogenic nerve lesion. Cryobiology 28:460–466

    Article  PubMed  CAS  Google Scholar 

  • DeLeo JA, Coombs DW, Willenbring S, Colburn RW, Fromm C, Wagner R, Twitchell BB (1994) Characterization of a neuropathic pain model: sciatic cryoneurolysis in the rat. Pain 56:9–16

    Article  PubMed  CAS  Google Scholar 

  • Dickenson AH, Sullivan AF (1987) Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurons following C-fiber stimulation. Neuropharmacology 26:1235–1238

    Article  PubMed  CAS  Google Scholar 

  • Dickenson AH, Sullivan AF (1990) Differential effects of excitatory amino acid antagonists on dorsal ociceptive neurones in the rat. Brain Res 506:31–9

    Article  PubMed  CAS  Google Scholar 

  • Dougherty PM, Garrison CJ, Carlton SM (1992) Differential influence of local anesthetic upon two models of experimentally induced peripheral mononeuropathy in the rat. Brain Res 570:109–115

    Article  PubMed  CAS  Google Scholar 

  • Dubuisson D, Dennis SG (1977) The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain 4:161–174

    Article  PubMed  CAS  Google Scholar 

  • Gebhart GF, Ness TJ (1991) Central mechanisms of visceral pain. Can J Physiol Pharmacol 69:627–634

    Article  PubMed  CAS  Google Scholar 

  • Goettl VM, Larson AA (1994) Activity at phencyclidine and mu Opioid sites mediates the hyperalgesic and antinociceptive properties of the N-terminus of substance P in a model of visceral pain. Neuroscience 60:375–382

    Article  PubMed  CAS  Google Scholar 

  • Haley JE, Sullivan AF, Dickenson AH (1990) Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat. Brain Res 518:218

    Article  PubMed  CAS  Google Scholar 

  • Hoheisel U, Mense S, Simons DG, Yu XM (1993) Appearance of new receptive fields in rat dorsal horn neurons following noxious stimulation of skeletal muscle — a model for referral of muscle pain. Neurosci Lett 153:9–12

    Article  PubMed  CAS  Google Scholar 

  • Hoheisel U, Koch K, Mense S (1994) Functional reorganization in the rat dorsal horn during an experimental myositis. Pain 59:111–118

    Article  PubMed  CAS  Google Scholar 

  • Hunskaar S, Berge OG, Hole K (1985) Antinociceptive effets of orphenadrine citrate in mice. Eur J Pharmacol 111:221–226

    Article  PubMed  CAS  Google Scholar 

  • Hunskaar S, Berge OG, Hole K (1986) A modified hot-plate test sensitive to mild analgesics. Behav Brain Res 21:101–108

    Article  PubMed  CAS  Google Scholar 

  • Hunt SP, Pini A, Evan G (1987) Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature 328:632–634

    Article  PubMed  CAS  Google Scholar 

  • Hylden JLK, Wilcox GL (1983) Pharmacological characterization of substance P-induced nociception in mice: modulation by Opioid and noradrenergic agonists at the spinal level. J Pharmacol Exp Ther 226:398–404

    PubMed  CAS  Google Scholar 

  • Iadorola MJ, Douglass J, Civelli O, Naranjo JR (1988) Differential activation of spinal cord dynorphin and enkephalin neurons during hyperalgesia: evidence using cDNA hybridization. Brain Res 455:205–212

    Article  CAS  Google Scholar 

  • Kanui TI, Hole K, Miaron JO (1990) Nociception in crocodiles — capsaicin installation, formalin and hot plate test. Zool Sci 7:537–540

    Google Scholar 

  • Kayser V, Guilbaud G (1987) Local and remote modifications of nociceptive sensitivity during carrageenan-induced inflammation in the rat. Pain 28:99–107

    Article  PubMed  CAS  Google Scholar 

  • Kim SH, Chung JM (1992) An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50:355–363

    Article  PubMed  CAS  Google Scholar 

  • Kim SH, Na HS, Sheen K, Chung JM (1993) Effects of sympathectomy on a rat model of peripheral neuropathy. Pain 55:85–92

    Article  PubMed  CAS  Google Scholar 

  • King AE, Thompson SWN, Urban L, Woolf CJ (1988) An intracellular analysis of amino acid induced excitation of deep dorsal horn neurons in the rat spinal cord slice. Neurosci Lett 89:286–292

    Article  PubMed  CAS  Google Scholar 

  • Koster R, Anderson M, deBeer EJ (1959) Acetic acid for analgesic screening. Fed Proc 18:412

    Google Scholar 

  • Kress M, Koltzenburg M, Reeh PW, Handwerker HO (1992) Responsiveness and functional attributes of electrically localized terminals of cutaneous C-fibers in vivo and in vitro. J Neurophysiol 68:581–595

    PubMed  CAS  Google Scholar 

  • Lascelles BDX, Waterman AE, Cripps PJ, Livingston A, Henderson G (1995) Central sensitization as a result of surgical pain: investigation of the pre-emptive value of pethidine for ovariohysterectomy in the rat. Pain 62:201–212

    Article  PubMed  CAS  Google Scholar 

  • Luukko M, Konttinen Y, Kemppinen P, Pertovaara A (1994) Influence of various experimental parameters on the incidence of thermal and mechanical hyperalgesia induced by a constriction mononeuropathy of the sciatic nerve in lightly anesthetized rats. Exp Neurol 128:143–154

    Article  PubMed  CAS  Google Scholar 

  • Malcangio M, Malmberg-Aiello P, Giotti A, Ghelardini C, Bartolini A (1992) Desensitization of GABA-B receptors and antagonism by CGP 35348, prevent bicuculline- and picrotoxin-induced antinociception. Neuropharmacology 31:783–791

    Article  PubMed  CAS  Google Scholar 

  • Merskey M (1984) Pain terms: a list with definitions and notes on usage. Recommended by the International Association for the Study of Pain Subcommittee on Taxomony. Pain 18:287–297

    Article  Google Scholar 

  • Minor BG, Archer T, Post C, Jonsson G, Mohammed AK (1986) 5-HT agonist induced analgesia modulated by central but not peripheral noradrenaline depletion in rats. J Neural Transm 66:243–259

    Article  PubMed  CAS  Google Scholar 

  • Mjellem-Joly N, Lund A, Berge OG, Hole K (1991) Potentiation of a behavioural response in mice by spinal coadministration of substance P and excitatory amino acid agonists. Neurosci Lett 133:121–124

    Article  PubMed  CAS  Google Scholar 

  • Okuda K, Nakahama H, Miyakawa H, Shima K (1984) Arthritis induced in cat by sodium urate; a possible animal model for tonic pain. Pain 18:287–297

    Article  PubMed  CAS  Google Scholar 

  • Perkins MN, Campbell E, Dray A (1993) Antinociceptive activity of the bradykinin Bl and B2 receptor antagonists, des-Arg9, (Leu8)-BK and HOE 140, in two models of persistent hyperalgesia in the rat. Pain 53:191–197

    Article  PubMed  CAS  Google Scholar 

  • Pircio A, Fedele C, Bierwagen M (1975) A new method for the evaluation of analgesic activity using adjuvant-induced arthritis in the rat. Eur J Pharmacol 31:207–215

    Article  PubMed  CAS  Google Scholar 

  • Presley RW, Menétrey D, Levine JD, Basbaum AI (1990) Systemic morphine suppresses noxious stimulus evoked Fos protein-like immunoreactivity in the rat spinal cord. J Neurosci 10:323–335

    PubMed  CAS  Google Scholar 

  • Randall LO, Selitto JJ (1957) A method for measurement of analgesic activity on inflamed tissue. Arch Int Pharmacodyn Ther 111:409–418

    PubMed  CAS  Google Scholar 

  • Ren K, Hylden JL, Williams GM, Ruda MA, Dubner R (1992) The effects of a non-competitive NMD A receptor antagonist, MK-801, on behavioural hyperalgesia and dorsal horn neuronal activity in rats with unilateral inflammation. Pain 50:331–344

    Article  PubMed  CAS  Google Scholar 

  • Roberts VJ (1989) Ethical issues in the use of animals for pain research. In: Chapman CR, Loeser JD (eds) Advances in pain research and therapy, vol 12. Raven, New York, pp 169–174

    Google Scholar 

  • Rosland JH (1991) The formalin test in mice: the influence of ambient temperature. Pain 45:211–216

    Article  PubMed  CAS  Google Scholar 

  • Rosland JH, Tjølsen A, Mæhle B, Hole K (1990) The formalin test in mice: effect of formalin concentration. Pain 42:235–242

    Article  PubMed  CAS  Google Scholar 

  • Seltzer Z, Dubner R, Shir Y (1990) A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain 43:205–218

    Article  PubMed  CAS  Google Scholar 

  • Sheen K, Chung JM (1993) Signs of neuropathic pain depend on signals from injured nerve fibers in a rat model. Brain Res 610:62–68

    Article  PubMed  CAS  Google Scholar 

  • Sherrington C (1947) The integrative action of the nervous system, 2nd edn. Yale University Press, New Haven

    Google Scholar 

  • Shir Y, Seltzer Z (1990) A-fibers mediate mechanical hyperesthesia and allodynia and C-fibers mediate thermal hyperalgesia in a new model of causalgiform pain disorders in rats. Neurosci Lett 115:62–67

    Article  PubMed  CAS  Google Scholar 

  • Shir Y, Seltzer Z (1991) Effects of sympathectomy in a model of causalgiform pain produced by partial sciatic nerve injury in rats. Pain 45:309–320

    Article  PubMed  CAS  Google Scholar 

  • Siegmund E, Cadmus R, Lu G (1957) A method for evaluating both non-narcotic and narcotic analgesics. Proc Soc Exp Biol Med 95:729

    PubMed  CAS  Google Scholar 

  • Skilling SR, Smullin DH, Beitz AJ, Larson AA (1988) Extracellular amino acid concentrations in the dorsal spinal cord of freely moving rats following veratridine and nociceptive stimulation. J Neurochem 51:127–132

    Article  PubMed  CAS  Google Scholar 

  • Stanfa LC, Sullivan AF, Dickenson AH (1992) Alterations in neuronal excitability and the potency of spinal mu, delta and kappa Opioids after carrageenan-induced inflammation. Pain 50:345–354

    Article  PubMed  CAS  Google Scholar 

  • Stevens CW (1992) Alternatives to the use of mammals for pain research. Life Sci 50:901–912

    Article  PubMed  CAS  Google Scholar 

  • Størkson R, Kjørsvik A, Tjølsen A, Hole K (1996) Lumbar catheterization of the spinal subarachnoid space in the rat. J Neurosci Methods 65:167–172

    Article  PubMed  Google Scholar 

  • Taber RI (1974) Predictive value of analgesic assays in mice and rats. In: Braude MC, Harris LS, May EL, Smith JP, Villarreal JE (eds) Narcotic antagonists. Raven, New York, pp 191–211 (Advances in biochemical psychopharmacology, vol 8)

    Google Scholar 

  • Tanck EN, Kroin JS, McCarthy RJ, Penn RD, Ivankovich AD (1992) Effects of age and size on developement of allodynia in a chronic pain model produced by a sciatic nerve ligation in rats. Pain 51:313–316

    Article  PubMed  CAS  Google Scholar 

  • Tjølsen A, Lund A, Berge OG, Hole K (1989) An improved method for tail flick testing with adjustment for tail skin temperature. J Neurosci Methods 33:259–265

    Article  Google Scholar 

  • Tjølsen A, Berge OG, Hole K (1991a) Lesion of bulbo-spinal serotonergic or noradrenergic pathways reduce nociception as measured by the formalin test. Acta Physiol Scand 142:229–236

    Article  PubMed  Google Scholar 

  • Tjølsen A, Rosland JH, Berge OG, Hole K (1991b) The increasing temperature hot plate test: an improved test of nociception in mice and rats. J Pharmacol Methods 25:241–250

    Article  PubMed  Google Scholar 

  • Tjølsen A, Berge OG, Hunskaar S, Rosland JH, Hole K (1992) The formalin test: an evaluation of the method. Pain 51:5–17

    Article  PubMed  Google Scholar 

  • Tonussi CR, Ferreira SH (1992) Rat knee-joint carrageenin incapacitation test: an objective screen for central and peripheral analgesics. Pain 48:421–427

    Article  PubMed  CAS  Google Scholar 

  • Vinegar R, Truax JF, Selph JL (1976) Quantitative comparison of the analgesic and antiinflammatory activities of aspirin, phenacetin and acetaminophen in rodents. Eur J Pharmacol 37:23–30

    Article  PubMed  CAS  Google Scholar 

  • Wall PD, Devor M, Inbal R, Scadding JW, Schonfeld D, Seltzer Z, Tomkiewicz MM (1979) Autotomy following peripheral nerve lesions: experimental anesthesia dolorosa. Pain 7:103–113

    Article  PubMed  CAS  Google Scholar 

  • Wiesenfeld Z, Lindblom U (1980) Behavioural and electrophysiological effects of various types of peripheral nerve lesions in the rat: a comparison of possible models of chronic pain. Pain 8:285–298

    Article  PubMed  CAS  Google Scholar 

  • Wilcox GL (1988) Pharmacological studies of grooming and scratching behaviour elicted by spinal substance P and excitatory amino acids. Ann NY Acad Sci 525:228–236

    Article  PubMed  CAS  Google Scholar 

  • Willenbring S, Deleo JA, Coombs DW (1994) Differential behavioral outcomes in the sciatic cryoneurolysis model of neuropathic pain in rats. Pain 58:135–140

    Article  PubMed  CAS  Google Scholar 

  • Woolf CJ, King AE (1990) Dynamic alterations in the cutaneous mechanore-ceptive fields of dorsal horn neurons in the rat spinal cord. J Neurosci 10(8):2717–2726

    PubMed  CAS  Google Scholar 

  • Woolf CJ, Thompson SWN (1991) The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states. Pain 44:293–299

    Article  PubMed  CAS  Google Scholar 

  • Woolfe G, MacDonald AD (1944) The evaluation of the analgesic action of pethidine hydrocholoride (demerol). J Pharmacol Exp Ther 80:300307

    Google Scholar 

  • Xu XJ, Hao JX, Aldskogius H, Seiger Å, Wiesenfeld-Hallin Z (1992) Chronic pain related syndrome in rats after ischemic spinal cord lesion: a possible animal model for pain in patients with spinal cord injury. Pain 48:279–290

    Article  PubMed  CAS  Google Scholar 

  • Zimmermann M (1983) Ethical guidlines for investigations of experimental pain in conscious animals. Pain 16:109–110

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. A. Tjølsen
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  2. K. Hole
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Editors and Affiliations

  1. Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK

    A. Dickenson

  2. Physiopharmacologie du Système Nerveux et Laboratioire de Physiopharmacologie de la Douluer (EPHE), INSERM, U.161, 2, rue d’Alésia, F-75014, Paris, France

    J.-M. Besson

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© 1997 Springer-Verlag Berlin Heidelberg

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Tjølsen, A., Hole, K. (1997). Animal Models of Analgesia. In: Dickenson, A., Besson, JM. (eds) The Pharmacology of Pain. Handbook of Experimental Pharmacology, vol 130. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60777-6_1

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  • DOI: https://doi.org/10.1007/978-3-642-60777-6_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64550-1

  • Online ISBN: 978-3-642-60777-6

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