Zusammenfassung
Die Vorgänge der Wundheilung sind seit Jahrtausenden Grundlage der Tätigkeiten der chirurgischen Fächer (des „Wundarztes“). Die morphologischen Vorgänge des Wundheilungsprozesses wurden aber erst seit der Jahrhundertwende systematisch untersucht.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Alexander JW, MacMillan BG, Law E, Kittur DS (1981) Treatment of severe burns with widely meshed skin autograft and meshed skin allograft overlay. J Trauma 21:433 ff
Andree C, Swain WF, Page CP, Macklin MD, Slama J, Hatzis D, Eriksson E (1994) In vivo transfer and expression of a human epidermal growth factor gene accelerates wound repair. Proc Natl Acad Sci USA 91:12188–12192
Bromberg BE, et al (1965) The use of pig skin as a temporary biological dressing. Plast Reconstr Surg 36:80 ff
Brown GL, Curtsinger L, Jurkiewicz MJ, Nahai F, Schultz G (1991) Stimulation of healing of chronic wounds by epidermal growth factor. Plast Reconstr Surg 88:189 ff
Brown GL, Nanney LB, Griffen J, Cramer AB, Yancey JM, Curtsinger LJ, Holtzin L, Schultz GS, Jurkiewicz MJ, Lynch JB (1989) Enhancement of wound healing by topical treatment with epidermal growth factor. N Engl J Med 321:76 ff
Bryant WM (1977) Wound healing. CIBA Clinical Symposia Vol 29, No 3
Buckley A, Davidson JM, Kamerath CD, Wolt TB, Woodward SC (1987) Epidermal growth factor increases granulation tissue formation dose dependently. J Surg Res 43:322–328
Cheng L, Ziegelhoffer PR, Yang N-S (1993) In vivo promoter activity and transgene expression in mammalian somatic tissues evaluated by using particle bombardment. Proc Natl Acad Sci USA 90:4455–4459
Clark RAF, Winn HJ, Dvorak HF, Colvin RB (1983) Fibronectin beneath reepithelializing epidermis in vivo: sources and significance. J Invest Dermatol 80:26s–30s
Cohen IK, Crossland MC, Garrett A, Diegelmann RF (1995) Topical application of epidermal growth factor onto partial-thickness wounds in human volunteers does not enhance reepithelialization. Plast Reconstr Surg 96 (2) 251–254
Cohen IK, McCoy BJ (1980) The biology and control of surface overhealing. World J Surg 4:289–295
Cohen S (1962) Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eylid opening in the new-born animal. J Biol Chem 237 (5):1555–1562
Cohen S (1965) The stimulation of epidermal proliferation by a specific protein. Develop Biol 12:394 ff
Cornetta K, Morgan RA, Anderson WF (1991) Safety issues related to retroviral-mediated gene transfer in humans. Hum Gene Ther 2:5–14
Daughaday WH, Rotwein P (1989) Insulin-like growth factors I and II peptide, messenger ribonucleic acid and gene structures serum and tissue concentrations. Endocrin Rev 10:68–90
Diegelmann RF, Cohen IK, McCoy BJ (1979) Growth kinetics in collagene synthesis of normal skin, normal scar, and kelloid fibroblasts in vitro. J Cell Physiol 98:341
Ding Y, Pu S, Wu D (1983) Clinical and histological observations on the application of intermingled auto and porcineskin heterografts in third degree burns. Burns 9:381 ff
Donaldson DJ, Mahan JT (1983) Fibrinogen and fibronectin as substrates for epidermal cell migration during wound closure. J Cell Sci 62:117–127
Donaldson DJ, Mahan JT (1988) Keratinocyte migration and the extracellular matrix. J Invest Dermatol 90:623–628
Doornbos JF, Stoffel TJ, Hass AC (1990) The role of kilovoltage irradiation in the treatment of keloids. Int J Radiat Oncol Biol Phys 18:833–839
Eming SA, et al. J Invest Dermatol, in press
Finch P, Rubin P, Miki T, Ron D, Aaronson SA (1989) Human KGF is FGF-Related with properties of a paracrine effector of epithelial cell growth. Science 245:752–755
Gallico GG, O’Conner NE, Compton CC, Kehinde O, Green H (1984) Permanent coverage of large burn wounds with autologous cultured epithelium. New Engl J Med 311 (7):448–451
Heck EL, Bergstresser PR, Baxter CR (1985) Composite skin graft: frozen dermal allografts support the engraftment and expansion of autologous epidermis. J Trauma 25:106 ff
Hendry PJ, Mikat EM, Anstadt MP, Plunkett MD, Lowe JE (1993) Argon beam coagulation compared with cryoablation of ventricular subendocardium. Annals of Thoracic Surgery 55:135–139
Hermans RP (1983) The use of human allografts in the treatment of scalds in children. Panminerva Med 25:155 ff
Herndon DN, Rutan RL (1992) Comparison of cultured epidermal autograft and massive excision with serial autograft in plus homograft overlay. J Burn Care Rehabil 13(1):154–157
Horch R, Stark GB, Kopp J (1994) Histology after grafting of cultured keratinocyte-fibrin-glue suspension (KFGS) with allogenic split-thickness-skin (STS) overlay. Ellipse 11:1–6
Horch R, Stark GB, Kopp J, Spilker G (1993) Cologne Burn Centre: clinical experiences and histological findings using glycerol-preserved allogenic skin: overgraft and sandwich technique. Burns 19
Kaiser HW, Stark GB, Kopp J, Balcerkiewiecz A, Spilker G, Kreysel HW (1994a) Cultured autologous keratinocytes in fibrin glue suspension exclusively and combined with STS allograft (preliminary clinical and histological report of a new technique). Burns 20:23 ff
Kreis RW, Hoekstra MJ, Mackie DP, Vloemanns AFPM, Hermans RP (1992) Historical appraisal of the use of skin allografts in the treatment of extensive full skin thickness burns at the Red Cross Hospital Burns Centre, Beverwijk, The Netherlands. Burns 18 Supplement 2, S19 ff
Kreis RW, Vloemans AF, Hoekstra MJ (1989) The use of non-viable glycerol-preserved cadaver skin combined with widely expanded autografts in the treatment of extensive third degree burns. J Trauma 29:51 ff
Lawrence WT (1991) In search of the optimal treatment of keloids: report of a series and a review of the literature. Ann Plast Surg 27:164–178
Leader RW, Padget GA (1981) The genesis and validation of animal models. Am J Path 101:11–17
Leman CJ (1992) Splints and accessories following burn reconstruction [Review]. Clinics in Plastic Surgery 19:721–731
Lin S-D, Lai C-S, Chou C-K, Tsai C-W, Wu K-F, Chang C-W (1992) Microskin autograft with pigskin xenograft overlay: a preliminary report of studies on patients. Burns 18:321–325
Lynch SE, Colvin RB, Antoniades HN (1989) Growth factors in wound healing. J Clin Invest 84:640–646
Madden JW, Peacock EE (1971) Studies on the biology of collagen during wound healing. III. Dynamic metabolism of scar collagen and remodeling of dermal wounds. Ann Surg 174:511
Mühlbauer W, Henckel von Donnersmarck G, Hoefter E, Hartinger A (1995) Keratinozytenzüchtung und -transplantation bei Verbrennungen. Chirurg 66:271–276
Mulligan RC (1993) The basic science of gene therapy. Science 260:926–932
Murray JC, Pollack SV, Pinnel SR (1981) Keloids: a review. J Am Acad Dermatol 4:461–470
Mustoe TA, Pierce GF, Thomason A, Gramates P, Sporn MB, Deufel TF (1987) Accelerated healing of incisional wounds in rats induced by transforming growth factor-ß. Science 237:1333–1336
O’Malley BW (1989) Editorial: Did eucaryotic steroid receptors evolve from intracrine gene regulators. Endocrinology 125:1119–1120
Oluwasanmi JO (1979) In Plastic Surgery in the Tropics. London, MacMillan
Peacock EE (1980) Collagenolysis: The other side of the equation. World J Surg 4:297–299
Rappaport I, et al (1970) Early use of xenografts as biologic dressing in burn trauma. Am J Surg 120:144 ff
Roesel JF, Nanney LB (1995) Assessment of differential cytokine effects on angiogenesis using an in vivo model of cutaneous wound repair. J Surg Res 58 (5):449–459
Rohrich RJ, Robinson JB (1992) Wound healing and closure, abnormal scars tattoos, envenomation and extravasation injuries. Selected Readings in Plastic Surgery July
Russel JD, Witt WS (1976) Cell size and growth characteristics of cultured fibroblasts isolated from normal and keloid tissue. Plast Reconstr Surg 57:207
Sawada Y (1993) Pressure developed under pressure garment. British Journal of Plastic Surgery 46:538–541
Slavin J, Unemori E, Hunt TK, Amento E (1994) Transforming growth factor beta (TGF-ß) and dexamethasone have direct opposing effects on collagen metabolism in low passage human dermal fibroblasts in vitro. Growth factors 11:205–213
Spilker G, Stark GB (1991) Quality-of-life considerations in plastic and reconstructive surgery. Theor Surg 6:216–220
Stark GB, Kaiser HW (1994) Cologne Burn Center experience with glycerol-preserved allogeneic skin: Part II: Combination with autologous cultured keratinocytes. Burns 20:34–38
Stark GB, Kaiser HW, Horch R, Kopp J, Spilker G (1995) Cultured autologous keratinocytes suspended in fibrin glue (KFGS) with allogenic overgraft for definitive burn wound coverage. Eur J Plast Surg 18:267–271
Stark GB, Kaiser HW, Kopp J, Balcerkiewiecz A, Spilker G, Kreysel HW (1992) Kultivierte autologe Keratinozyten in einer Fibrin-Matrix zur Deckung von Brandwunden. 30th Annual Meeting of the German Society for Plastic and Reconstructive Surgery, Berlin, 8–10 October
Stenn KS, Madri JA, Roll FJ (1979) Migrating epidermis produces AB 2 collagen and requires continued collagen synthesis for movement. Nature 137:158
Temin HM (1990) Safety considerations in somatic gene therapy of human diseases with retrovirus vectors. Hum Gene Ther 1:111–123
Tompkins RG, Burke JF (1986) Burn therapy 1985: acute management. Intensive Care Med 12: 289 ff
Tompkins RG, Burke JF, Schoenfeld DA, Bondoc CC, Quinby WC, Behringer GC, Ackroyd FW (1986) Prompt eschar excision: a treatment system contributing to reduced burn mortality. A statistical evaluation of burn care at the Massachusetts General Hospital (1974–1984). Ann Surg 204:272 ff
Vogt PM, Andree C, Breuing K, Liu PY, Slama J, Helo G, Eriksson E (1995) Dry, moist, and wet skin wound repair. Ann plast surg 34 (5):493–499
Vogt PM, Thompson S, Andree C, Liu PY, Breuing K, Hatzis D, Brown H, Mulligan RC, Eriksson E (1994) Genetically modified keratinocytes transplanted to wounds reconstitute the epidermis. Proc Natl Acad Sci USA 91:9307–9311
Willital GH, Heine H (1994) Efficacy of Contractubex gel in the treatment of fresh scars after thoracic surgery in children and adolescents. International Journal of Clinical Pharmacology Research 14:193–202
Yang CC, Shih TS, Chu TA, Hsu WS, Kuo SY, Chao YF (1981) The intermingled transplantation of auto- and homografts in severe burns. Burns 6:141–145
Yang N-S (1992) Gene transfer into mammalian somatic cells in vivo. Crit Rev Biotechnol 12:335–356
Yang N-S, Burkholder J, Roberts B, Martinelli B, McCabe D (1990) In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment. Proc Natl Acad Sci USA 87:9568–9572
Zhang ML, Chang ZD, Hanx, et al (1986a) Microskin grafting. I. Animal experiments. Burns 12:540 ff
Zhang ML, Chang ZD, Wang CY (1988) Microskin grafting in the treatment of extensive burns: a preliminary report. J Trauma 28:804 ff
Zhang ML, Wang C-Y, Chang ZD, et al (1986b) Microskin grafting. II. Clincal report. Burns 12:544 ff
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Andree, C., Kopp, J., Stark, G.B. (1997). Wundheilung. In: Berger, H.G., Schwarz, A., Brückner, U.B., Hartel, W. (eds) Forschung in der Chirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60765-3_31
Download citation
DOI: https://doi.org/10.1007/978-3-642-60765-3_31
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-62705-0
Online ISBN: 978-3-642-60765-3
eBook Packages: Springer Book Archive