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Immunostimulation and Vaccination Therapy of Human Immunodeficiency Virus Infection

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Book cover Strategies for Immunointerventions in Dermatology

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Abstract

If any infectious disease seems to be a candidate for therapy via immunostimulation, human immunodeficiency virus (HIV) is the one, HIV has a devastating and profound impact on the immune system. This retrovirus causes a progressive destruction and misfunction of CD4+ lymphocytes after selectively binding to a surface receptor on their membranes [1]. Since CD4+ lymphocytes are pivotal in the immune response to infections, their loss leads to a cascade of secondary immune dysfunction [2–4] and an increased risk of infection, frequently to exotic pathogens. In addition, HIV-induced autoimmune phenomena, inappropriate mechanisms of T cell death, and dysregulation of other normal homeostatic mechanisms of the immune system play a role in the pathogenesis of the disease [5],

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Authors
  1. N. S. Penneys
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Editor information

Editors and Affiliations

  1. Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, CH-8091, Zurich, Switzerland

    Günter Burg M.D. (Chairman) (Chairman)

  2. Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, CH-8091, Zurich, Switzerland

    Reinhard G. Dummer M.D.

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© 1997 Springer-Verlag Berlin Heidelberg

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Penneys, N.S. (1997). Immunostimulation and Vaccination Therapy of Human Immunodeficiency Virus Infection. In: Burg, G., Dummer, R.G. (eds) Strategies for Immunointerventions in Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60752-3_27

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  • DOI: https://doi.org/10.1007/978-3-642-60752-3_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64539-6

  • Online ISBN: 978-3-642-60752-3

  • eBook Packages: Springer Book Archive

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