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Psoriasis- Mediation of Skin Phenotype by Circulatory Pathogenic T Lymphocytes

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Strategies for Immunointerventions in Dermatology

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Abstract

Psoriasis is one of the most common skin diseases present throughout the worldwide population affecting about 2% of individuals [1]. It has several different clinical appearances, but the most common phenotype consists of symmetrically distributed, persistent erythematous scaling plaques.Within these cutaneous lesions, there is infiltration of inflammatory cells, prominent keratinocyte hyperplasia with altered differentiation, neovascularization of the dermis,and activation of immunocompetent cells-T cells and dendritic antigen-presenting cells [2]. One of the most difficult problems for investigators studying this disease is to be able to determine with certainty which cellular and molecular events are of primary importance and which changes are secondary. The confederacy of cell types participating in this disorder, together with the panoply of cytokines and the rapidity of evolution and disappearance of skin lesions, has confounded even the most astute clinicians and bench researchers for the past century. Perhaps the greatest obstacle has been the lack of an appropriate and relevant animal model that recapitulates all of the important and characteristic cutaneous changes present in human psoriatic plaques.

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Authors
  1. B. J. Nickoloff
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Editors and Affiliations

  1. Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, CH-8091, Zurich, Switzerland

    Günter Burg M.D. (Chairman) (Chairman)

  2. Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, CH-8091, Zurich, Switzerland

    Reinhard G. Dummer M.D.

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© 1997 Springer-Verlag Berlin Heidelberg

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Nickoloff, B.J. (1997). Psoriasis- Mediation of Skin Phenotype by Circulatory Pathogenic T Lymphocytes. In: Burg, G., Dummer, R.G. (eds) Strategies for Immunointerventions in Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60752-3_22

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  • DOI: https://doi.org/10.1007/978-3-642-60752-3_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64539-6

  • Online ISBN: 978-3-642-60752-3

  • eBook Packages: Springer Book Archive

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