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Cytokines with Immunosuppressive Capacities

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Strategies for Immunointerventions in Dermatology

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Abstract

The current concept of the regulation of inflammatory and immune responses implies positive and negative signals which are mediated by a complex network of interacting cytokines. In contrast to the large body of data describing upregulating effects of many cytokines on these processes, only few suppressor factors with anti-immmune and anti-inflammatory properties have been identified [86,93]. In the search for suppressor factors, many investigations have concentrated on the identification of inhibitory cytokines produced by tumors, since release of such factors could represent a potential escape mechanism from immunosurveillance. Accordingly, several tumors including melanoma, basal cell carcinomas, and squamous cell carcinomas were found to release distinct suppressor factors [76,107,121].

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Authors
  1. T. A. Luger
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  2. M. Böhm
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Editors and Affiliations

  1. Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, CH-8091, Zurich, Switzerland

    Günter Burg M.D. (Chairman) (Chairman)

  2. Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, CH-8091, Zurich, Switzerland

    Reinhard G. Dummer M.D.

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© 1997 Springer-Verlag Berlin Heidelberg

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Luger, T.A., Böhm, M. (1997). Cytokines with Immunosuppressive Capacities. In: Burg, G., Dummer, R.G. (eds) Strategies for Immunointerventions in Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60752-3_10

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  • DOI: https://doi.org/10.1007/978-3-642-60752-3_10

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