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A Rational Approach to Immune Intervention

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Strategies for Immunointerventions in Dermatology

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Abstract

Not too long ago, it was still a mystery how the immune system was able to recognize the infinite number of viruses, bacteria, and other parasites and foreign elements. It was thought that antigens served as a template around which antibodies molded themselves to gain a complementary form. In 1955, Niels K. Jerne was the first to suggest that the immune response was selective rather than instructive, i e , that the immune system has the capacity to synthesize billions of different antibodies and that encountering antigen only increases production of the antibody that makes the best fit. Soon afterwards, Macfarlane Burnet and David Talmage suggested that each lymphocyte bears only one particular antibody as a receptor and that, after encounter with antigen, it divides to start mass production of the relevant antibody. Later, Susumu Tonegawa elucidated the molecular mechanism that generates the enormous diversity of antibodies, and discovery of the genes coding for the T cell receptor (TCR) by Tak W. Mak revealed that TCR diversity is generated in a similar way.

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Authors
  1. T. M. Kündig
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Editors and Affiliations

  1. Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, CH-8091, Zurich, Switzerland

    Günter Burg M.D. (Chairman) (Chairman)

  2. Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, CH-8091, Zurich, Switzerland

    Reinhard G. Dummer M.D.

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© 1997 Springer-Verlag Berlin Heidelberg

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Kündig, T.M. (1997). A Rational Approach to Immune Intervention. In: Burg, G., Dummer, R.G. (eds) Strategies for Immunointerventions in Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60752-3_1

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  • DOI: https://doi.org/10.1007/978-3-642-60752-3_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64539-6

  • Online ISBN: 978-3-642-60752-3

  • eBook Packages: Springer Book Archive

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