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Molekularbiologische Ansätze zur Entwicklung neuer Behandlungsformen für das AIDS-assoziierte Kaposi-Sarkom

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Book cover HIV-Infekt

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Zusammenfassung

Kaposi-Sarkom-(KS-)Zellen wurden aus KS-Biopsien der Haut von AIDS-Patienten kultiviert. Kultivierte KS-Zellen weisen ein identisches Muster der Genexpression wie die KS-Spindelzellen in vivo auf, die als die eigentlichen Tumorzellen des KS betrachtet werden. Aufgrund dieser Übereinstimmung kann davon ausgegangen werden, daß kultivierte KS-Zellen den KS-Spindelzellen entsprechen. Diese Zellkulturen wurden als ein In-vitro-Modellsystem für Untersuchungen zur KS-Pathogenese und -therapie eingesetzt.

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Abbreviations

FKS:

fötales Kälberserum

gp130:

Glykoprotein 130

HIV-1:

humanes Immunschwäche Virus-1

IFN:

Interferon

IL:

Interleukin

KS:

Kaposi-Sarkom

LIF:

„leukemia inhibitory factor“

MCP-1:

„monocyte chemoattractant protein-1“

PDGF:

„plateletderived growth factor“

TGF-β:

„transforming growth factor-β“

VEGF:

„vascular endothelial growth factor“

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Authors
  1. M. Stürzl
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  2. R. Dah-Shuhn
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  3. R. Köster
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Editor information

Editors and Affiliations

  1. Klinik und Poliklinik für Dermatologie, Venerologie, Allergologie, Universitätsklinikum Essen, Hufelandstraße 55, 45122, Essen, Germany

    Norbert H. Brockmeyer  & Lutz Mertins  & 

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© 1997 Springer-Verlag Berlin Heidelberg

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Stürzl, M., Dah-Shuhn, R., Köster, R. (1997). Molekularbiologische Ansätze zur Entwicklung neuer Behandlungsformen für das AIDS-assoziierte Kaposi-Sarkom. In: Brockmeyer, N.H., Mertins, L. (eds) HIV-Infekt. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60722-6_10

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  • DOI: https://doi.org/10.1007/978-3-642-60722-6_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64525-9

  • Online ISBN: 978-3-642-60722-6

  • eBook Packages: Springer Book Archive

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