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Betablocker — im Mittelpunkt der Forschung pp 9–20Cite as

ß-Rezeptor-Subtypen beim Menschen

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Zusammenfassung

Bereits zu Beginn dieses Jahrhunderts wies der Befund, daß Mutterkornalkaloide nur gewisse Effekte von Adrenalin blockieren konnten, auf das Konzept verschiedener adrenerger Rezeptorsubtypen hin. Diese Vorstellung wurde jedoch ignoriert, bis Ahlquist 1948 nachwies, daß es 2 Gruppen adrenerger Rezeptoren gibt, die jeweils ein spezifisches pharmakologisches Profil aufweisen [1]. Die α-adrenergen Rezeptoren wurden mit der Mehrzahl der erregenden Wirkungen assoziiert (z. B. Vasokonstriktion und Kontraktion der glatten Uterusmuskulatur) der ß-adrenerge Rezeptor wurde mit der Mehrzahl der hemmenden Wirkungen (z. B. Vasodilatation und Relaxation der glatten Uterus- und Bronchialmuskulatur) und einer wichtigen erregenden Wirkung (Myokardstimulation) in Verbindung gebracht.

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Authors
  1. G. Vauquelin
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Editor information

Editors and Affiliations

  1. Institut für Pharmakologie, Med. Universität zu Lübeck, Ratzeburger Allee 160, D-23538, Lübeck, Germany

    P. Dominiak

  2. Division of Cardiology, Sahlgrenska University Hospital, S-413345, Göteborg, Germany

    A. Hjalmarson

  3. Clinical Pharmacology Section, University of Birmingham, Edgbaston, Brimingham B15 2TH, Edgbaston, UK

    M. J. Kendall

  4. Innere Medizin III, Universität Heidelberg, Bergheimer Str. 58, D-69115, Heidelberg, Germany

    W. Kübler

  5. Astra Hässle AB, Clinical R&D, S-43183, Mölndal, Sweden

    G. Olsson

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© 1997 Springer-Verlag Berlin Heidelberg

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Vauquelin, G. (1997). ß-Rezeptor-Subtypen beim Menschen. In: Dominiak, P., Hjalmarson, A., Kendall, M.J., Kübler, W., Olsson, G. (eds) Betablocker — im Mittelpunkt der Forschung. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60716-5_3

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  • DOI: https://doi.org/10.1007/978-3-642-60716-5_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64522-8

  • Online ISBN: 978-3-642-60716-5

  • eBook Packages: Springer Book Archive

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