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Effect of Lithium on the Thyroid Gland

  • Chapter
Pharmacotherapeutics of the Thyroid Gland

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 128))

Abstract

The history of the introduction of lithium into medicine has been reviewed by Johnson (1984). Lithium was discovered in 1817 and accounts for about 0.006% of the earth’s crust. It belongs in Group IA in the Periodic Table of Elements but shares some physical properties with magnesium (Group IIA). The main use of lithium in therapeutics is in the treatment and prophylaxis of manic depressive psychosis. In the first half of the twentieth century lithium was used as a salt substitute in patients with cardiac failure but severe toxicity prevented its acceptance. In 1949 J.F.J.Cade, an Australian psychiatrist, noticed that guinea pigs who had been given lithium urate during an investigation into the role of uric acid in manic patients became less startled. This led to the trial administration of lithium to manic depressive patients (Cade 1949) and then to the widely acclaimed studies of Schou and colleagues in defining the clinical effectiveness of this ion in psychiatry (Schou et al. 1954; Schou 1957).

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  1. J. H. Lazarus
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Editors and Affiliations

  1. Department of Medicine Clinical Sciences Centre Northern General Hospital, The University of Sheffield, Sheffield, S5 7AU, UK

    A. P. Weetman (Professor of Medicine) (Professor of Medicine)

  2. Department of Endocrinology, St. Bartholomew’s Hospital, West Smithfield, London, EC1A 7BE, UK

    A. Grossman

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Lazarus, J.H. (1997). Effect of Lithium on the Thyroid Gland. In: Weetman, A.P., Grossman, A. (eds) Pharmacotherapeutics of the Thyroid Gland. Handbook of Experimental Pharmacology, vol 128. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60709-7_9

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  • DOI: https://doi.org/10.1007/978-3-642-60709-7_9

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