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Immunomodulatory Agents in Autoimmune Thyroid Disease

  • Chapter
Pharmacotherapeutics of the Thyroid Gland

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 128))

  • 258 Accesses

Abstract

The term autoimmune thyroid disease encompasses several common disorders: Hashimoto’s thyroiditis, primary myxoedema, Graves’ disease and postpartum thyroiditis, as well as the subclinical forms of these disorders. The basis for these disorders has been reviewed extensively (Weetman and McGregor 1994); this chapter will concentrate on the effect of immunomodulatory agents, beginning in each section with the results from animal models of experimental autoimmune thyroiditis (EAT). The close relationship between thyroid-associated ophthalmopathy (TAO) and autoimmune thyroid disease suggests a common pathogenesis. This autoimmune eye disorder may be disfiguring and a threat to vision. Since developments in immunotherapy are likely to have their greatest impact in this condition, because present agents have major side effects and a suboptimal effect, immunomodulation in TAO is considered separately, at the end of the chapter.

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  1. A. P. Weetman
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Editors and Affiliations

  1. Department of Medicine Clinical Sciences Centre Northern General Hospital, The University of Sheffield, Sheffield, S5 7AU, UK

    A. P. Weetman (Professor of Medicine) (Professor of Medicine)

  2. Department of Endocrinology, St. Bartholomew’s Hospital, West Smithfield, London, EC1A 7BE, UK

    A. Grossman

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© 1997 Springer-Verlag Berlin Heidelberg

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Weetman, A.P. (1997). Immunomodulatory Agents in Autoimmune Thyroid Disease. In: Weetman, A.P., Grossman, A. (eds) Pharmacotherapeutics of the Thyroid Gland. Handbook of Experimental Pharmacology, vol 128. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60709-7_14

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  • DOI: https://doi.org/10.1007/978-3-642-60709-7_14

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