Abstract
Transgenic overexpression of human acetylcholinesterase (AChE) was employed as an experimental tool for creating a subtle cholinergic imbalance in vertebrates. In Xenopus laevis tadpoles, transgenic AChE accelerated the development of neuromuscular junctions. In stably transgenic mice, overexpression of AChE was associated with deterioration in both cognitive and neuromotor functions, suggesting requirement for balanced cholinergic transmission for stable maintenance of these functions. However, transfections of cultured glioma cells demonstrated a morphogenic activity for AChE which was apparently non-catalytic. This suggested that putatively distinct feedback mechanisms are activated in response to the catalytic and non-catalytic activities of excess AChE, which causes the observed symptoms.
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© 1997 Springer-Verlag Berlin Heidelberg
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Sternfeld, M., Seidman, S., Beeri, R., Soreq, H. (1997). Catalytic and Non-Catalytic Activities of Acetylcholinesterase Implied from Transgenic ACHE Expression in Vertebrates. In: Pöğün, Ş. (eds) Neutrotransmitter Release and Uptake. NATO ASI Series, vol 100. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60704-2_22
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DOI: https://doi.org/10.1007/978-3-642-60704-2_22
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