Skip to main content
SpringerLink
Log in
Book cover

Neutrotransmitter Release and Uptake pp 145–154Cite as

GABAB Receptor Control of Neurotransmitter Release in Mammalian Brain: Modification During Chronic Inflammation

  • Conference paper

  • 197 Accesses

Part of the book series: NATO ASI Series ((ASIH,volume 100))

Abstract

The evidence for a GABA receptor which was distinct from the classical chloride-dependent ionotropic receptor first emerged in mammalian peripheral tissues (Bowery et al 1981; see Bowery 1989). In a variety of isolated nerve-smooth muscle and atrial muscle preparations, GABA and its analogue, ß-chlorophenyl GABA (baclofen), were shown to depress the contractile response to nerve stimulation. A typical example of this is shown in Figure 1 where increasing concentrations of baclofen produced a decrease in contraction of the twitch response of the rat anoccocygeus muscle. This reduction in contraction was produced by a decrease in transmitter release from the autonomic innervation. No evidence for any effect at the postsynaptic site was observed. Thus, in general, the influence of GABA was restricted to the nerve input and could be construed as acting on the presynaptic release mechanism in peripheral tissues. The characteristics of the receptor mediating this effect showed little resemblance to the established GABA receptor but it seemed unlikely that it had any physiological significance, perhaps with the exception of the enteric nervous system where GABA neurones have been demonstrated (see Kerr & Ong 1995).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Battaglia, G., Rustioni, A. (1988). Coexistence of glutamate and substance P in dorsal root ganglion neurons of the rat and monkey. J. Comp. Neurol., 277, 302.

    Article  PubMed  CAS  Google Scholar 

  • Bonanno, G., Raiteri, M. (1993). Multiple GABAB receptors. Trends Pharmacol. Sci., 14: 259–261.

    Article  PubMed  CAS  Google Scholar 

  • Bowery, N.G. (1989). GABAB receptors and their significance in mammalian pharmacology. Trends Pharmacol. Sci. 10, 401–407.

    Article  PubMed  CAS  Google Scholar 

  • Bowery, N.G., (1993). GABAB Receptor Pharmacology. Annu. Rev. Pharmacol. Toxicol. 109–147.

    Google Scholar 

  • Bowery, N.G., Doble, A., Hill, D.R., Hudson, A.L., Shaw, J.S., Turnbull, M.J. and Warnngton, R. (1981). Bicuculline-insenstive GABA receptor on peripheral autonomic nerve terminals. Eur. J. Pharmacol. 71: 53–70.

    Article  PubMed  CAS  Google Scholar 

  • Bowery, N.G., Hill, D.R., and Hudson A.L. (1983). Characteristics of GABAB receptor binding sites on rat whole brain synaptic membranes, Br. J. Pharmacol. 78, 191.

    PubMed  CAS  Google Scholar 

  • Bowery, N.G., Hill, D.R., Hudson, A.L., Doble, A., Middlemiss, D.N., Shaw J. and Turnbull, M. (1980) (-) Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor. Nature 283: 92–94.

    Article  PubMed  CAS  Google Scholar 

  • Castro-Lopes, J.M., Malcangio, M., Pan, B.H., Bowery, N.G. (1995). Complex changes of GABAA and GABAB receptor binding in the spinal cord dorsal horn following peripheral inflammation or neurectomy. Brain Research 679, 289–297.

    Article  PubMed  CAS  Google Scholar 

  • Castro-Lopes, J.M., Tavares, I., Tolle, T.R., Coito, A., Coimbra, A. (1992). Increase in GABAergic cells and GABA levels in the spinal cord in unilateral inflammation of the hindlimb of the rat. Eur. J. Neurosci, 4, 296–301.

    Article  PubMed  Google Scholar 

  • Crunelli, V., Leresche, N. (1991). A role for GABAB receptors in excitation and inhibition of thalamocortical cells. Trends Neurosci. 14:16–21.

    Article  PubMed  CAS  Google Scholar 

  • De Biasi, S., Rustioni, A. (1988). Glutamate and substance P co-exist in primary afferent terminals in the superficial laminae of spinal cord. Proc. Natl. Acad. Sci. USA 85, 7820–7824.

    Article  PubMed  Google Scholar 

  • Deisz, R. A., Billard, J.M. and Zieglgansberger, W. (1993). Pre and postsynaptic GABAB receptors of rat neocortical neurones differ in their pharmacological properties. Neuroscience Letters 154, 209–212.

    Article  PubMed  CAS  Google Scholar 

  • Donnerer, J., (1991). Depolarization-evoked release of glutamate, aspartate and γ- aminobutyric acid from rat dorsal spinal cord slices does not originate from capsaicinsenstive neurons, Brain Res. 555, 332.

    Article  PubMed  CAS  Google Scholar 

  • Dutar, P., Nicoll, R.A. (1988a). A physiological role for GABAB receptors in the central nervous system. Nature 332:156–158.

    Article  PubMed  CAS  Google Scholar 

  • Dutar, P., Nicoll, R.A. (1988b). Pre-and postsynaptic GABAB receptors in the hippocampus have different pharmacological properties. Neuron 1: 585–598.

    Article  PubMed  CAS  Google Scholar 

  • Gemignani, A., Paudic, P., Bonanno, G. and Raiteri M. (1994). Pharmacological Discrimination Between γ-Aminobutyric Acid Type B Receptors Regulating Cholecystokinin and Somatostatin Release from Rat Neocortex Synaptosomes. Mol. Pharmacol., 45, 558–562.

    Google Scholar 

  • Giovannini, G., Lacey M.G., Pepeu G., Nistri, A. (1991). Release of endorgenous glutamate and aspartate from frog spinal cord in vitri. Eur. J. Pharmacol., 195, 47.

    Article  PubMed  CAS  Google Scholar 

  • Hargreaves, K., Dubner, R., Brown, F., Flores, C, Joris, J. (1988). A new and sensitive method for measuring thermal nmociception in cutaneous hyperalgesia. Pain, 32, 77–88.

    Article  PubMed  CAS  Google Scholar 

  • Harrison, N.L. (1990). On the presynaptic action of baclofen at inhibitory synapses between cultured rat hippocampal neurones. J. Physiol. 422: 433–446.

    PubMed  CAS  Google Scholar 

  • Hill, D.R., Bowery, N.G. (1981) 3H-Baclofen and 3H-GABA bind to bicucullineinsensitive GABAB sites in rat brain. Nature 290:149–152.

    Article  PubMed  CAS  Google Scholar 

  • Isaacson, J.S., Solis, J.M. and Nicoll, R.A. (1993). Local and diffuse synaptic actions of GABA in the hippocampus. Neuron 10:165–175.

    Article  PubMed  CAS  Google Scholar 

  • Kangrga, I., Jiang, M. Randic, M. (1991). Action of (-)baclofen on rat dorsal horn neurones. Brain Res. 562, 265.

    Article  PubMed  CAS  Google Scholar 

  • Kangrga, I., Larew J.S.A., Randic, M. (1990). The effects of substance P and calcitonin-gene-related peptide on the efflux of endogenous glutamate and aspartate from rat spinal dorsal horn in-vitro. Neurosci. Lett., 108, 155.

    Article  PubMed  CAS  Google Scholar 

  • Kangrga, I., Randic, M. (1991). Outflow of endogenous amino acids from the rat spinal dorsal horn slice in response to low- and high-threshold primary afferent fibres. Modulation of µ-opioids, Brain Res. 553, 347.

    Article  PubMed  CAS  Google Scholar 

  • Kar, S., Gibson, S.J., Rees, R.G., Jura, W.G.Z.O., Brewerton, D.A., Polak, J.M. (1991). Increased calcitonin-gene-related peptide (CGRP), substance P and enkephalin immunoreactivities in dorsal spinal cord and loss of CGRP-immunoreactive motoneurons in arthritic rats depend on intact peripheral nerve supply. J. Mol. Neurosci. 3, 7–18.

    Article  PubMed  CAS  Google Scholar 

  • Karlsson, G., Pozza, M. and Olpe, H.-R. (1988). Phaclofen: a GABAB blocker reduces long-duration inhibition in the neocortex. Eur. J. Pharmacol. 148: 485–486.

    Article  PubMed  CAS  Google Scholar 

  • Kerr, D.I.B. and Ong, J. (1995). GABAB receptors. Pharmac. Ther., 67, 187–246.

    Article  CAS  Google Scholar 

  • Magoul, R. Onteniente, B., Geffard, M. & Calas, S. (1987). Anatomical distribution and ultrastructural organization of the GABAergic system in the rat spinal cord. An immunocytochemical study using anti-GABA antibodies. Neuroscience, 20, 1001–1009.

    Article  PubMed  CAS  Google Scholar 

  • Malcangio, M., Bowery, N.G. (1993). γ-Aminobutyric acidB, but not γ-aminobutyric acidA receptor activation, inhibits electrically-evoked substance P-like immunoreactivity from rat spinal cord in vitro. J. Pharmacol. Exp. Ther., 266, 1490–1496.

    PubMed  CAS  Google Scholar 

  • Malcangio, M, Bowery, N.G. (1993). Gamma-aminobutyric acidB but not ammaamino butyric and acidA receptor activation inhibits electrically evoked substance Plike immunoreactivity release from the rat spinal cord in Vitro. J. Pharmac. Exp. Ther., 266, 1490–1496.

    CAS  Google Scholar 

  • Malcangio, M. and Bowery, N.G. (1994). Spinal cord SP release and hyperalgesia in monoarthritic rats: involvement of the GABAB receptor system. Br. J. Pharmacol. 113:1561–1566.

    PubMed  CAS  Google Scholar 

  • Malcangio, M., and Bowery, N.G. 1994. Spinal cord SP release and hyperalgesia in onoarthritic rats: involvement of the GABAB receptor system. Br. J. Pharmacol. 13, 1561.

    Google Scholar 

  • Malcangio, M., Libri, V., Teoh, H., Constanti, A. and Bowery, N.G. (1995). Chronic (-) baclofen or CGP 36742 alters GABAB receptor senstivity in rat brain and spinal cord. Neuroreport, 6: 339–403.

    Article  Google Scholar 

  • Malcangio, M., Libri, V., Teoh, H., Constanti, A., Bowery, N.G. (1995). Chronic (-) baclofen or CGP 36742 alters GABAB receptor sensitivity in rat brain and spinal cord. Neuroreport 6, 399–403.

    Article  PubMed  CAS  Google Scholar 

  • Malcangio, M., Silva Da H., Bowery N.G. (1993). Plasticity of GABAB receptor in rat spinal cord detected by autoradiography, Eur. J. Pharmacol. 250, 153.

    Article  PubMed  CAS  Google Scholar 

  • Minami, M., Kuraishi, Y., Kawamura, M., Yamaghuchi, T., Masu, Y., Nakanishi, S., Satoh, M. (1989). Enhancement of preprotachykinin in the rat spinal cord: possible involvement of substance P-containing spinal neurons in nociception. Neurosci. Lett., 98, 105–110.

    Article  PubMed  CAS  Google Scholar 

  • Mott, D.D., Lewis, D.L. The pharmacology and function of GABAB receptors. Int. Rev. Neurobiol. 36: 97–223, 1994.

    Article  PubMed  CAS  Google Scholar 

  • Oku, R., Satoh, M. & Tagaki, H., (1987). Release of substance P from the spinal dorsal horn is enhanced in polyarthritic rats. Neurosci. Lett., 74, 315–319.

    Article  PubMed  CAS  Google Scholar 

  • Penn, R.D., Savoy, S.M., Corcos, D., Latash, M., Gottlieb, G., et al. 1989. Intrathecal baclofen for severe spinal spasticity. N. Engl. J. Med. 320:1517–21.

    Article  PubMed  CAS  Google Scholar 

  • Penn, R.R. and Mangieri, E.A. (1993). Stiff-man syndrome treated with intrathecal baclofen. Neurology 43: 2412.

    PubMed  CAS  Google Scholar 

  • Pittaluga, A., Asaro, D., Pettegrinni, G. and Raiteri, M. (1987). Studies of 3H-GABA and endogenous GABA release in rat cerebral cortex suggest the presence of autoreceptors of the GABAB type. Eur. J. Pharmacol. 144: 45–52.

    Article  PubMed  CAS  Google Scholar 

  • Pratt, G.D., Bowery, N.G. (1993). Repeated administration of desipramine and a GABAB receptor antagonist, CGP 36742, discretely up-regulates rat frontal cortical GABAB receptor binding sites. Br. J. Pharmacol., 110, 724–735.

    PubMed  CAS  Google Scholar 

  • Price, G.W. Kelly, J.S., Bowery, N.G. (1987). The location of GABAB receptor binding sites in mammalian spinal cord. Synapse 1:530–38.

    Article  PubMed  CAS  Google Scholar 

  • Price, G.W., Blackburn, T.P., Hudson, A.L. Bowery, N.G. 1984. Presynaptic GABAB sites in the interpeduncular nucleus. Neuropharmacology 23:861–62.

    Article  CAS  Google Scholar 

  • Raiteri, M., Giralt, M.T., Bonanno, G., Pittaluga, A., Fedele, E. and Fontana, G. (1990). Release-regulating GABA autoreceptors in human and rat central nervous system. In: GABAB receptors in mammalian function. Eds: Bowery, N.G., Bittiger, H. & Olpe H.-R. Publ. Wiley, Chichester pp 81–98.

    Google Scholar 

  • Skilling, S.R., Larson, A.A. (1993). Capsaicin inhibits whereas rhizotomy potentiates substance P-induced release of excitatory amino acids in the rat spinal cord in vivo. Neurosci. Lett. 150, 107.

    Article  PubMed  CAS  Google Scholar 

  • Sluka, K.A., Dougherty, P.M., Okin, L.S., Willis, W.D., Westlund, K.N. (1992). Neuronal changes in acute arthritis in monkey III. Changes in subtance P, CGRP and glutamate in the dorsal horn of the spinal cord. Brain Res. Rev., 17, 29–38.

    Article  PubMed  CAS  Google Scholar 

  • Teoh, H., Malcangio, M., and Bowery N.G. (1996a). The effects of novel GABAB antagonists on the release of amino acids from spinal cord of the rat. Br. J. Pharmacol. (in press).

    Google Scholar 

  • Teoh, H., Malcangio, M., Fowler, L.J. & Bowery, N.G. (1996b). Evidence for release of glutamic acid, aspartic acid and substance P but not γ-aminobutyric acid from primary afferent fibres in rat spinal cord. Eur. J. Pharmacol (in press).

    Google Scholar 

  • Todd, A.J. & McKenzie, J. (1989). GABA-immunoreactive neurons in the dorsal horn of the rat spinal cord. Neuroscience, 3 1, 799–806.

    Article  Google Scholar 

  • Waldmeier, P.C., Wicki, P., Feldtrauer, J.-J., Mickel, S.J. Bittiger, H. and Baumann, P.A. (1994). GABA and glutamate release affected by GABAB receptor antagonists with similar potency: no evidence for pharmacologically different presynaptic receptors. Br. J. Pharmacol. 113, 151–1521.

    Google Scholar 

  • Waldovogel, H.J., Faull, R.L.M., Jansen, K.L.R, Dragunow, J., Richards, J.G., Mohler, H., Streit, P., (1990). GABA. GABA receptors and benzodiazepine receptors in the human spinal cord: an autoradiographic and immunohistochemical study at the light and electron microscopic levels. Neuroscience 39, 361.

    Article  Google Scholar 

  • Westlund, K.N., McNeill, D.L., Patterson, J.T. Coggeshall, R.E. (1989b). Aspartate immunoreactive axons in normal rat L4 dorsal roots. Brain Res. 489, 347.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Medical School, University of Birmingham, Edgbaston, Birmingham, B 15 2TT, UK

    N. G. Bowery, M. Malcangio & H. Teoh

Authors
  1. N. G. Bowery
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Malcangio
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. Teoh
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Center for Brain Research, Ege University, Bornova, Izmir, 35100, Turkey

    Şakire Pöğün

  2. Department of Physiology, Ege University School of Medicine, Bornova, Izmir, 35100, Turkey

    Şakire Pöğün

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Bowery, N.G., Malcangio, M., Teoh, H. (1997). GABAB Receptor Control of Neurotransmitter Release in Mammalian Brain: Modification During Chronic Inflammation. In: Pöğün, Ş. (eds) Neutrotransmitter Release and Uptake. NATO ASI Series, vol 100. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60704-2_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-60704-2_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64517-4

  • Online ISBN: 978-3-642-60704-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation