Skip to main content

Histological Aspects of Sepsis-Induced Brain Changes in a Baboon Model

  • Conference paper
Shock, Sepsis, and Organ Failure

Abstract

Encephalopathy is one of the organ dysfunctions seen in critically ill patients with multiple organ dysfunction syndrome (MODS) secondary to sepsis (defined as the systemic response to infection).

This paper is dedicated to Prof. Hermann Esterbauer. We lost a fantastic colleague and wonderful friend.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Beerthuizen GIJM (1993) Response of the microcirculation: Tissue oxygenation. In: Schlag G, Redl H (eds) Pathophysiology of shock, sepsis, and organ failure. Springer Berlin Heidelberg New York, pp 230–256

    Chapter  Google Scholar 

  2. Booke M, Traber LD, Traber DL (1994) Vasodilatators in sepsis. In: Schlag G, Redl H, Traber DL (eds) Shock, sepsis and organ failure-nitric oxide. Fourth Wiggers Bernard Conference. Springer Berlin Heidelberg New York, pp 243–258

    Google Scholar 

  3. Bradley HE, Fitch W (1994) Biochemical markers of cerebral ischaemia. In: Sebel PS, Fitch W (eds) Monitoring the cerebral nervous system. Blackwell, London, pp 26–50

    Google Scholar 

  4. Braughler JM, Hall ED (1989) Central nervous system trauma and stroke I. Biochemical considerations of oxygen radical formation and lipid peroxidation. Free Radic Biol Med 6:289–301

    Article  CAS  PubMed  Google Scholar 

  5. Breslow MJ, Traystman RJ (1993) Neurologic abnormalities in sepsis. In: Schlag G, Redl H (eds) Pathophysiology of shock, sepsis, and organ failure. Springer Berlin Heidelberg New York, pp 996–1003

    Chapter  Google Scholar 

  6. Brown KW, Kynoch PAM, Thompson RJ (1980) Immunoreactive nervous system specific enolase (14-3-2 protein) in human serum and cerebrospinal fluid. Clin Chim Acta 101:257–264

    Article  CAS  PubMed  Google Scholar 

  7. Campbell IL, Chiang CS (1995) Cytokine involvement in central nervous system disease. Ann N Y Acad Sci 771:301–312

    Article  CAS  PubMed  Google Scholar 

  8. Cross A, Asher L, Seguin M, Yuan L, Kelly N, Hammack C, Sadoff J, Gemski P (1995) The importance of a lipopolysaccharide initiated cytokine mediated host defense mechanism in mice against extraintestinally invasive Escherichia coli. J Clin Invest 96:676–686

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  9. Dauberschmidt R, Marangos PJ, Zinsmeyer J, Bender V, Klages G, Gross J (1983) Severe head trauma and the changes of concentration of neuron specific enolase in plasma and in cerebrospinal fluid. Clin Chim Acta 131:165–170

    Article  CAS  PubMed  Google Scholar 

  10. Esterbauer H (1993) Cytotoxicity and genototxicity of lipid-peroxidation products. Am J Clin Nutr 57[Suppl]:779S–786S

    CAS  PubMed  Google Scholar 

  11. Esterbauer H, Weger W (1967) Über die Wirkungen von Aldehyden auf gesunde und maligne Zellen; Synthese von homologen 4-Hydroxy-2-alkenalen. Chem Monthly 98:1884–1891

    Article  CAS  Google Scholar 

  12. Esterbauer H, Schaur RJ, Zollner H (1991) Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 11:81–128

    Article  CAS  PubMed  Google Scholar 

  13. Freeman BA, Topolosky MK, Crapo JD (1982) Hyperoxia increases oxygen radical production in rat lung homogenates. Arch Biochem Biophys 216:477–484

    Article  CAS  PubMed  Google Scholar 

  14. Goris RJA, Nuytinck HKS, Redl H (1986) Scoring system and predictors of ARDS and MOF. Prog Clin Biol Res 236B:3–15

    Google Scholar 

  15. Grcevic N (1982) Topography and pathogenic mechanisms of lesions in “inner cerebral trauma”. Rad JAZU 402:265–331

    Google Scholar 

  16. Hall ED, Braughler JM (1989) Central nervous system trauma and stroke II. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation. Free Radic Biol Med 6:289–301

    Article  PubMed  Google Scholar 

  17. Hasselgren PO, Fischer JE, Meyer TA, Tiao G (1994) Inhibition of nitric oxide synthase during sepsis and endoxemia may be detrimental. In: Schlag G, Redl H, Traber DL (eds) Shock, sepsis and organ failure-nitric oxide. Fourth Wiggers Bernard Conference, Springer Berlin Heidelberg New York, pp 198–213

    Google Scholar 

  18. Hullin DA, Brown KB, Knoxh PAM, Smith C, Thompson RJ (1980) Human 14-3-2 protein: purification, radioimmunoassay and distribution in human tissue. Biochim Biophys Acta 628:98–108

    Article  CAS  PubMed  Google Scholar 

  19. Jamieson D, Chance B, Cadenas E, Boveris A (1986) The relation of free radical production to hyperoxia. Annu Rev Physiol 48:703–719

    Article  CAS  PubMed  Google Scholar 

  20. Jellinger K (1978) Brain mono-amines in human hepatic encephalopathy. Acta Neuropathol (Berl) 43:63–68

    Article  CAS  Google Scholar 

  21. Katusic ZS, Schugel J, Consentino F, Vanhoutte PM (1993) Endothelium-dependent contractions to oxygen-derived free radicals in the canine basilar artery. Am J Physiol 257:H859–H864

    Google Scholar 

  22. Marangos PJ, Schmechel D, Parma AM, Clark RL, Goodwin FK (1979) Measurement of neuron specific enolase (NSE) and non neuronal specific enolase (NNE) isoenzymes in enolase of rat, monkey and human nervous tisse. J Neurochem 33:319–329

    Article  CAS  PubMed  Google Scholar 

  23. Martinez MC, Bosch-Morell F, Raya A, Roma J, Aldasoro M, Vila J, Lluch S, Romero FJ (1994) 4-Hydroxynonenal, a lipid peroxidation product, induces relaxation of human cerebral arteries. J Cereb Blood Flow Metab 14:693–696

    Article  PubMed  Google Scholar 

  24. McCann SM, Lyson K, Karanth S, Gimeno M, Belova N, Kamat A, Rettori V (1995) Mechanisms of action of cytokines to induce the pattern of pituitary hormone secretion in infection. Ann N Y Acad Sci 771:386–395

    Article  CAS  PubMed  Google Scholar 

  25. Meyer J, Stothert JC Jr, Pollard V (1993) Nitric oxide synthesis inhibition in ovine endotoxemia: effects on brain blood flow. Anesth Analg 76:S264

    Google Scholar 

  26. Parrat JR (1994) Nitric oxide and cardiovascular dysfunction in sepsis and endotoxaemia. In: Schlag G, Redl H, Traber DL (eds) Shock, sepsis and organ failure-nitric oxide. Fourth Wiggers Bernard Conference, Springer Berlin Heidelberg New York, pp 1–29

    Google Scholar 

  27. Parrat JR, Stoclet JC, Fleming I (1993) The role of L-arginine nitric oxide pathway in sepsis and endotoxaemia with special reference to vascular impairment. In: Schlag G, Redl H (eds) Pathophysiology of shock, sepsis, and organ failure. Springer Berlin Heidelberg New York, pp 575–592

    Chapter  Google Scholar 

  28. Redl H, Gasser H, Hallström S, Schlag G (1993) Radical related cell injury. In: Schlag G, Redl H (eds) Pathophysiology of shock, sepsis, and organ failure. Springer Berlin Heidelberg New York, pp 92–110

    Chapter  Google Scholar 

  29. Redl H, Dinges HP, Buurman WA, van der Linden C, Pober JS, Cotran RS, Schlag G (1991) Expression of endothelial leukocyte adhesion molecule-1 in septic but not traumatic/hypovolemic shock in the baboon. Am J Pathol 139:461–466

    CAS  PubMed  Google Scholar 

  30. Schlag G (1994) Shock models — relevance for human studies. Shock 2[Suppl]:41

    Article  Google Scholar 

  31. Schlag G, Redl H, van Vuuren CJJ, Davies J (1992) Hyperdynamic sepsis in baboons: II. Relation of organ damage to severity of sepsis evaluated by a newly developed morphological scoring system. Circ Shock 38:253–263

    CAS  PubMed  Google Scholar 

  32. Schlag G, Redl H, Davies J, van Vuuren CJJ, Smuts P (1993) Live Escherichia coli sepsis models in baboons. In: Schlag G, Redl H (eds) Pathophysiology of shock, sepsis, and organ failure. Springer Berlin Heidelberg New York, pp 1076–1107

    Chapter  Google Scholar 

  33. Seyr M, Mutz NJ (1993) Permeability changes. In: Schlag G, Redl H (eds) Pathophysiology of shock, sepsis, and organ failure. Springer Berlin Heidelberg New York, pp 176–193

    Chapter  Google Scholar 

  34. Stratakis CA, Chrousos GP (1995) Neuroendocrinology and pathophysiology of the stress system. Ann N Y Acad Sci 771:1–18

    Article  CAS  PubMed  Google Scholar 

  35. Strieter RM, Colletti LM, Metinko AP, Rolfe MW, DeMeester SR, Standiford TJ, Kunkel SL (1993) The role of cytokine networks mediating inflammation and ischemia-reperfusion injury. In: Schlag G, Redl H, Traber DL (eds) Shock, sepsis and organ failure. Third Wiggers Bernard Conference. Springer Berlin Heidelberg New York, pp 205–227

    Chapter  Google Scholar 

  36. Tapia FJ, Polak JM, Barbosa AJA, Bloom SR, Marangos PJ, Dermody C, Pearse AGE (1981) Neuron-specific enolase is produced by neuroendocrine tumours. Lancet 1:808–811

    Article  CAS  PubMed  Google Scholar 

  37. Vincent JL, Bakker J, Silance PG (1993) Relationship between oxygen demand and oxygen supply in severe sepsis. In: Schlag G, Redl H (eds) Pathophysiology of shock, sepsis, and organ failure. Springer Berlin Heidelberg New York, pp 908–914

    Chapter  Google Scholar 

  38. Waeg G, Dimsity G, Esterbauer H (1996) Monoclonal antibodies for detection of 4-hydroxynonenal modified proteins. Free Radic Biol Med 25:149–159

    CAS  Google Scholar 

  39. Wakayama Y, Shibuya S, Kawase J, Sagawa F, Hashizume Y (1987) High neuron specific enolase level in cerebrospinal fluid in the early stage of Creutzfeld-Jakob disease. Klin Wochenschr 65:798–801

    Article  CAS  PubMed  Google Scholar 

  40. Waterfall AH, Singh G, Fry JR, Marsden CA (1995) Detection of the lipid peroxidation product malondyaldehyde in the rat brain in vivo. Neurosci Lett 200:69–72

    Article  CAS  PubMed  Google Scholar 

  41. Zarkovic N, Ilic Z, Jurin M, Schaur RJ, Puhl H, Esterbauer H (1993) Stimulation of HeLa cell growth by physiological concentrations of 4-hydroxynonenal. Cell Biochem Funct 11:279–286

    Article  CAS  PubMed  Google Scholar 

  42. Zarkovic N, Schaur RJ, Puhl H, Jurin M, Esterbauer H (1994) Mutual dependence of growth modifying effects of 4-hydroxynonenal and fetal calf serum in vitro. Free Radic Biol Med 16:877–884

    Article  CAS  PubMed  Google Scholar 

  43. Zollner H, Schaur RJ, Esterbauer H (1991) Biological activities of 4-hydroxyalkenals. In: Sies H (ed) Oxidative stress. Academic London, pp 337–369

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Zarkovic, K., Zarkovic, N., Schlag, G., Redl, H., Waeg, G. (1997). Histological Aspects of Sepsis-Induced Brain Changes in a Baboon Model. In: Schlag, G., Redl, H., Traber, D. (eds) Shock, Sepsis, and Organ Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60698-4_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-60698-4_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64513-6

  • Online ISBN: 978-3-642-60698-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics