Cardiovascular Support by Hemodynamic Subset: Sepsis

  • A. Meier-Hellmann
  • K. Reinhart
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 28)


Multiple organ failure (MOF) is the major cause of death in patients with sepsis [1]. Macro and micro circulatory maldistribution of blood flow to the tissues and hypoxia of certain organs plays an important role in the pathogenesis of sepsis [2, 3]. In addition, there is evidence in the literature for an oxygen extraction deficit. Therefore a supranormal oxygen delivery (DO2) is considered by many to be essential for adequate tissue oxygenation [4, 5]. Sufficient volume substitution and treatment with catecholamines are usually required to achieve a supranormal oxygen delivery and an adequate systemic perfusion pressure. Despite this, the mortality rate of sepsis and the incidence of MOF remains persistantly high [6]. It is obvious that under the conditions of a supranormal D02 tissue hypoxia in various tissues may still occur [2, 4]. Information regarding perfusion and oxygenation in different regions of the body is mandatory for the detection of regional tissue hypoxia.


Septic Shock Mean Arterial Pressure Septic Patient Renal Blood Flow Hepatic Blood Flow 
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© Springer-Verlag Berlin Heidelberg 1997

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  • A. Meier-Hellmann
  • K. Reinhart

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