Physiology of VO2/DO2

  • J.-L. Vincent
  • P. van der Linden
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 28)


Cellular energy is supplied in the form of high energy phosphate compounds, such as ATP, by metabolic reactions involving the oxidation of hydrocarbons. The concentration of ATP in most cells is maintained by the mitochondrial electron transport systems. Under normal conditions the amount of oxygen present in the mitochondria greatly exceeds that required to maintain oxidative phosphorylation. However when oxygen delivery falls, less efficient anaerobic metabolism takes over, leading to lactate production and acidosis. Cellular processes fail as energy supplies fall, and organ system function deteriorates. Oxygen is thus essential for the normal activity and survival of tissues.


Oxygen Delivery Oxygen Extraction Oxygen Extraction Ratio Supply Dependency Mitochondrial Electron Transport System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • J.-L. Vincent
  • P. van der Linden

There are no affiliations available

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