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The Effect of High Pressure on Transcription and on the Structure and Activity of E. coli RNA Polymerase

  • Chapter
Mechanisms of Transcription

Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 11))

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Abstract

Intermolecular interactions play a vital role in the numerous steps of prokaryotic and eukaryotic transcription. Multiprotein complexes assemble at promoters and enhancer regions of the DNA, and proteins bound to distal as well as to adjacent regions of DNA can interact with each other (Kerppola and Kane 1991; Rippe et al. 1995). Ternary complexes appear to undergo cycles of protein conformational changes during the elongation phase of transcription by Escherichia coli RNA polymerase, and some of these structural rearrangements are sequence-dependent (Krummel and Chamberlin 1992; Nudler et al. 1994; Wang et al. 1995; Zaychikov et al. 1995). The termination (and antitermination) of transcription also involves the interaction of protein factors and newly synthesized RNA with DNA (Richardson 1993).

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Author information

Authors and Affiliations

  1. Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D-37077, Göttingen, Germany

    L. Erijman & R. M. Clegg

Authors
  1. L. Erijman
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  2. R. M. Clegg
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Editor information

Editors and Affiliations

  1. Max-Planck-Institut für Experimentelle Medizin, Hermann-Rein-Straße 3, 37075, Göttingen, Germany

    Fritz Eckstein

  2. Biochemistry Department, University of Dundee, DD1 4HN, Dundee, UK

    David M. J. Lilley

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© 1997 Springer-Verlag Berlin Heidelberg

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Erijman, L., Clegg, R.M. (1997). The Effect of High Pressure on Transcription and on the Structure and Activity of E. coli RNA Polymerase. In: Eckstein, F., Lilley, D.M.J. (eds) Mechanisms of Transcription. Nucleic Acids and Molecular Biology, vol 11. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60691-5_6

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  • DOI: https://doi.org/10.1007/978-3-642-60691-5_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64509-9

  • Online ISBN: 978-3-642-60691-5

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