Reduced Neuronal Activity is One of the Major Hallmarks of Alzheimer’s Disease

Conference paper
Part of the Research and Perspectives in Alzheimer’s Disease book series (ALZHEIMER)


Alzheimer’s disease (AD) is histopathologically characterized by the presence of neuritic plaques (NPs) and cytoskeletal changes (Fig. 1) that are visible as pretangles stained by Alz-50, neurofibrillary tangles (NFT) in the cell bodies of affected neurons, and neuropil threads (Braak et al. 1986) or dystrophic neurites (Kowall and Kosik 1987). Dystrophic neurites are defined as short, thickened, curly, coiled or sometimes hooked fibres observable as the neuritic component of NPs or present in the neuropil outside these structures. Neuropil threads is an alternative term for dystrophic neurites that are not the neuritic component of NPs. To a lesser degree, NPs and cytoskeletal changes can also be observed in aged, nondemented control subjects.


Senile Dementia Neuritic Plaque Dystrophic Neurites Neurobiol Aging Cytoskeletal Change 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  1. 1.Netherlands Institute for Brain ResearchAmsterdamThe Netherlands

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