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Reduced Neuronal Activity is One of the Major Hallmarks of Alzheimer’s Disease

  • Conference paper
Connections, Cognition and Alzheimer’s Disease

Part of the book series: Research and Perspectives in Alzheimer’s Disease ((ALZHEIMER))

Abstract

Alzheimer’s disease (AD) is histopathologically characterized by the presence of neuritic plaques (NPs) and cytoskeletal changes (Fig. 1) that are visible as pretangles stained by Alz-50, neurofibrillary tangles (NFT) in the cell bodies of affected neurons, and neuropil threads (Braak et al. 1986) or dystrophic neurites (Kowall and Kosik 1987). Dystrophic neurites are defined as short, thickened, curly, coiled or sometimes hooked fibres observable as the neuritic component of NPs or present in the neuropil outside these structures. Neuropil threads is an alternative term for dystrophic neurites that are not the neuritic component of NPs. To a lesser degree, NPs and cytoskeletal changes can also be observed in aged, nondemented control subjects.

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Authors and Affiliations

  1. Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands

    D. F. Swaab

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  1. D. F. Swaab
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  2. P. J. Lucassen
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  3. J. A. P. van de Nes
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  4. R. Ravid
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  5. A. Salehi
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Editor information

Editors and Affiliations

  1. Nuerology Service, Massachusetts General Hospital, Fruit Street, 02114, Boston, MA, USA

    B. T. Hayman M.D., Ph.D.

  2. Laboratoire de Neuropathologie R. Escourolle, Hôpital de La Salpêtrière, Blvd. de l’Hôpital, 75651, Paris Cedex 16, France

    C. Duyckaerts M.D., Ph.D.

  3. Fondation IPSEN, 24, rue Erlanger, 75651, Paris Cedex 16, France

    Y. Christen Ph.D.

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© 1997 Springer-Verlag Berlin Heidelberg

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Swaab, D.F., Lucassen, P.J., van de Nes, J.A.P., Ravid, R., Salehi, A. (1997). Reduced Neuronal Activity is One of the Major Hallmarks of Alzheimer’s Disease. In: Hayman, B.T., Duyckaerts, C., Christen, Y. (eds) Connections, Cognition and Alzheimer’s Disease. Research and Perspectives in Alzheimer’s Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60680-9_7

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  • DOI: https://doi.org/10.1007/978-3-642-60680-9_7

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