Cortical Mapping of Pathological Tau Proteins in Several Neurodegenerative Disorders
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One of the main features of numerous neurodegenerative disorders is the presence of specific inclusions in the cerebral cortex. In most of these disorders, these inclusions correspond to the aggregation of abnormal filaments. Neurofibrillary tangles (NFT) are commonly found in Alzheimer’s disease (AD), amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC), head injury, Hallervorden-Spatz disease and progressive supranuclear palsy (PSP). Pick’s disease (PiD), a form of fronto-temporal dementia, is characterized by the presence of chromatolytic neurons and Pick bodies (PB; Brion et al. 1991). Despite many microscopic and ultrastructural differences, these inclusions share similar antigenic properties (Dickson et al. 1985; Delacourte et al. 1990; Hof et al. 1994a, b). Tau immunoreactivity is observed in NFT of most of these neurodegenerative disorders and anti-Tau antibodies immmunolabel PB (Hof et al. 1994 a).
KeywordsProgressive Supranuclear Palsy Entorhinal Cortex Neurofibrillary Tangle Progressive Supranuclear Palsy Neurofibrillary Degeneration
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