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Cortical Mapping of Pathological Tau Proteins in Several Neurodegenerative Disorders

  • Conference paper
Book cover Connections, Cognition and Alzheimer’s Disease

Part of the book series: Research and Perspectives in Alzheimer’s Disease ((ALZHEIMER))

Abstract

One of the main features of numerous neurodegenerative disorders is the presence of specific inclusions in the cerebral cortex. In most of these disorders, these inclusions correspond to the aggregation of abnormal filaments. Neurofibrillary tangles (NFT) are commonly found in Alzheimer’s disease (AD), amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC), head injury, Hallervorden-Spatz disease and progressive supranuclear palsy (PSP). Pick’s disease (PiD), a form of fronto-temporal dementia, is characterized by the presence of chromatolytic neurons and Pick bodies (PB; Brion et al. 1991). Despite many microscopic and ultrastructural differences, these inclusions share similar antigenic properties (Dickson et al. 1985; Delacourte et al. 1990; Hof et al. 1994a, b). Tau immunoreactivity is observed in NFT of most of these neurodegenerative disorders and anti-Tau antibodies immmunolabel PB (Hof et al. 1994 a).

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Authors and Affiliations

  1. Unité INSERM 422, Place de Verdun, 59045, Lille cedex, France

    P. Vermersch

Authors
  1. P. Vermersch
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  2. V. Buée-Scherrer
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  3. L. Buée
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  4. J. P. David
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  5. A. Wattez
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  6. N. Sergeant
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  7. P. R. Hof
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  8. Y. Agid
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  9. D. P. Perl
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  10. C. W. Olanow
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  11. Y. Robitaille
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  12. D. Gauvreau
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  13. H. Petit
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  14. A. Delacourte
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Editor information

Editors and Affiliations

  1. Nuerology Service, Massachusetts General Hospital, Fruit Street, 02114, Boston, MA, USA

    B. T. Hayman M.D., Ph.D.

  2. Laboratoire de Neuropathologie R. Escourolle, Hôpital de La Salpêtrière, Blvd. de l’Hôpital, 75651, Paris Cedex 16, France

    C. Duyckaerts M.D., Ph.D.

  3. Fondation IPSEN, 24, rue Erlanger, 75651, Paris Cedex 16, France

    Y. Christen Ph.D.

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© 1997 Springer-Verlag Berlin Heidelberg

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Vermersch, P. et al. (1997). Cortical Mapping of Pathological Tau Proteins in Several Neurodegenerative Disorders. In: Hayman, B.T., Duyckaerts, C., Christen, Y. (eds) Connections, Cognition and Alzheimer’s Disease. Research and Perspectives in Alzheimer’s Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60680-9_4

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  • DOI: https://doi.org/10.1007/978-3-642-60680-9_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64504-4

  • Online ISBN: 978-3-642-60680-9

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