Abstract
Alzheimer pathology includes two main aspects (Duyckaerts et al. 1995): the extracellular deposition of ß amyloid (Aß) and the intracellular accumulation of abnormally phosphorylated tau protein. The relationship between these two markers and their link with dementia are still a matter of debate (Selkoe 1991; van de Nes et al. 1994). Tau pathology appears to be more closely associated with dementia than Aß deposition (Berg et al. 1993; McKee et al. 1991; Wilcock and Esiri 1982) but Aß could play the role of a trigger (Hardy 1992) and be the cause of a “cascade,” leading finally to the formation of neurofibrillary tangles and neuropil threads.
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References
Bancher C, Jellinger KA (1994) Neurofibrillary predominant form of Alzheimer’s disease: a rare subtype in very old subjects. Acta Neuropathol (Berlin) 88: 565 – 570
Berg L, McKeel DW, Miller P, Baty J, Morris JC (1993) Neuropathological indexes of Alzheimer’s disease in demented and nondemented persons aged 80 years and older. Arch Neurol 50: 349 – 358
Blessed G, Tomlinson BE, Roth M (1968) The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Brit J Psychiat 114: 797 – 811
Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berlin) 82: 239 – 259
Braak H, Duyckaerts C, Braak E, Piette F (1993) Neuropathological staging of Alzheimer-related changes correlates with psychometrically assessed intellectual status. In: Corain B, Iqbal K, Nicolini M, Winblad B, Wisniewski H, Zatta P (eds) Alzheimer’s disease: advances in clinical and basic research. Chichester, John Wiley & Sons, pp 131 – 137
Duyckaerts C, Hauw J-J, Bastenaire F, Piette F, Poulain C, Rainsard V, Javoy-Agid F, Berthaix P (1986) Laminar distribution of neocortical plaques in senile dementia of the Alzheimer type. Acta Neuropath (Berlin) 70: 249 – 256
Duyckaerts C, Godefroy G, Hauw J-J (1994) Evaluation of neuronal numerical density by Dirichlet tessellation. J Neurosci Meth 51: 47 – 69
Duyckaerts C, Delaère P, He Y, Camilleri S, Braak H, Piette F, Hauw J-J (1995) The relative merits of tau- and amyloid markers in the neuropathology of Alzheimer’s disease. In: Bergener M, Finkel SI (eds) Treating Alzheimer’s and other dementias. New York: Springer, pp 81 – 89
Duyckaerts C, Delaère P, He Y, Camilleri S, Braak H, Piette F, Hauw J-J (1995) The relative merits of tau- and amyloid markers in the neuropathology of Alzheimer’s disease. In: Bergener M, Finkel SI (eds) Treating Alzheimer’s and other dementias. New York: Springer, pp 81 – 89
Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L, Mant R, Newton P, Rooke K, Roques P, Talbot C, Pericak-Vance M, Roses A, Williamson R, Rossor M, Owen M, Hardy J (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s disease. Nature 349: 704 – 706
Hardy J (1992) An’anatomical cascade hypothesis’ for Alzheimer’s disease. Trends Neurosci 15: 200 – 201
Hauw J-J, Duyckaerts C, Delaère P, Chaunu MP (1988) Maladie d’Alzheimer, amyloïde, microglie et astrocytes. Rev Neurol (Paris) 144: 155 – 157
McKee AC, Kosik KS, Kowall NW (1991) Neuritic pathology and dementia in Alzheimer’s disease. Ann Neurol 30: 156 – 165
Probst A, Anderton BH, Brion JP, Ulrich J (1989) Senile plaque neurites fail to demonstrate anti-paired helical filament and anti-microtubule-associated protein tau immunoreactive proteins in the absence of neurofibrillary tangles in the neocortex. Acta Neuropathol 77: 430 – 436
Selkoe DJ (1991) Amyloid protein and Alzheimer disease. Sci Am November, 68 – 78
Uchihara T Duyckaerts C, He Y, Kobayashi K, Seilhan D, Amouyel P, Hauw J-J (1995a) ApoE immunoreactivity and microglial cells in Alzheimer’s disease brain. Neurosci Lett 195: 5 – 8
Uchihara T, Kondo H, Akiyama H, Ikeda K (1995 b) White matter amyloid in Alzheimer’s disease brain. Acta Neuropathol 90: 51–56
van de Nes JAP, Kamphorst W, Swaab DF (1994) Arguments for and against the primary amyloid local induction hypothesis of the pathogenesis of Alzheimer’s disease. Ann Psychiat 4: 95 – 111
van Hoesen G (1982) The parahippocampal gyrus. New observations regarding its cortical connections in the monkey. Trends Neurosci 5: 345 – 350
Wilcock GK, Esiri MM (1982) Plaques, tangles and dementia. A quantitative study. J Neurol Sci 57: 407 – 417
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Duyckaerts, C., Colle, MA., Bennecib, M., Grignon, Y., Uchihara, T., Hauw, JJ. (1997). Plaques and Tangles: Where and When?. In: Hayman, B.T., Duyckaerts, C., Christen, Y. (eds) Connections, Cognition and Alzheimer’s Disease. Research and Perspectives in Alzheimer’s Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60680-9_3
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DOI: https://doi.org/10.1007/978-3-642-60680-9_3
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