Is Alzheimer’s Disease Accelerated Aging? Different Patterns of Age and Alzheimer’s Disease-Related Neuronal Losses in the Hippocampus

Conference paper
Part of the Research and Perspectives in Alzheimer’s Disease book series (ALZHEIMER)


The hypothesis that Alzheimer’s disease is accelerated aging has been tested by comparing the patterns of neuron loss in the hippocampal region associated with normal aging and with Alzheimer’s disease. Qualitative differences were found in the patterns of loss in CA1, indicating that a unique neurodegenerative process not associated with normal aging is involved in Alzheimer’s disease.


Normal Aging Medial Temporal Lobe Hippocampal Region Pyramidal Cell Layer True Disease 
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  1. BachmanDL, Wolf PA, Linn RT, Knoefel JE, Cobb JL, Belanger AJ, White LR, D’Agostino RB (1993) Incidence of dementia and probable Alzheimer’s disease in a general population: The Framingham Study. Neurology 43: 515 – 519PubMedGoogle Scholar
  2. Berg L (1985) Does Alzheimer’s disease represent an exaggeration of normal aging? Arch Neurol 42: 737 – 739PubMedGoogle Scholar
  3. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science 261: 921 – 923PubMedCrossRefGoogle Scholar
  4. Hardy J, Mullan M, Chartier-Harlin MC (1991) Molecular classification of Alzheimer’s disease. Lancet 337: 1342Google Scholar
  5. Hyman BT, Van Hoesen GW, Damasio AR (1990) Memory-related neural systems in Alzheimer’s disease: an anatomic study. Neurology 40: 1721 – 1730PubMedGoogle Scholar
  6. Jobst KA, Smith AD, Szatmari M, Esiri MM, Jaskowski A, Hindley N, McDonald B, Molyneux AJ (1994) Rapidly progressing atrophy of medial temporal lobe in Alzheimer’s disease. Lancet 343: 829 – 830PubMedCrossRefGoogle Scholar
  7. KatzmanR, Terry R, DeTeresa R, Brown T, Davies P, Fuld P, Reubing X, Peck A (1988) Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques. Ann Neurol 23: 138 – 144PubMedCrossRefGoogle Scholar
  8. Khachaturian ZS (1985) Diagnosis of Alzheimer’s disease. Arch Neurol 42: 1097 – 1105PubMedGoogle Scholar
  9. West MJ, Gundersen HJG (1990) Unbiased stereological estimation of the number of neurons in the human hippocampus. J Compar Neurol 296: 1 – 22CrossRefGoogle Scholar
  10. West MJ, Coleman PD, Flood DG, Troncoso JC (1994) Differences in the pattern of hippocampal neuronal loss in normal aging and Alzheimer’s disease. Lancet 344: 769 – 772PubMedCrossRefGoogle Scholar
  11. Zola-Morgan S, Squire LR, Amarai DG (1986) Human amnesia and the medial temporal region: Enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus. J Neurosci 6: 2950 – 2967PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  1. 1.Department of Nuerobiology, Institute Of AnatonmyUniversity of AarhusAarhus CDenmark

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