Skip to main content
SpringerLink
Log in

Is Alzheimer’s Disease Accelerated Aging? Different Patterns of Age and Alzheimer’s Disease-Related Neuronal Losses in the Hippocampus

  • Conference paper
Connections, Cognition and Alzheimer’s Disease

Part of the book series: Research and Perspectives in Alzheimer’s Disease ((ALZHEIMER))

  • 161 Accesses

Summary

The hypothesis that Alzheimer’s disease is accelerated aging has been tested by comparing the patterns of neuron loss in the hippocampal region associated with normal aging and with Alzheimer’s disease. Qualitative differences were found in the patterns of loss in CA1, indicating that a unique neurodegenerative process not associated with normal aging is involved in Alzheimer’s disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • BachmanDL, Wolf PA, Linn RT, Knoefel JE, Cobb JL, Belanger AJ, White LR, D’Agostino RB (1993) Incidence of dementia and probable Alzheimer’s disease in a general population: The Framingham Study. Neurology 43: 515 – 519

    PubMed  CAS  Google Scholar 

  • Berg L (1985) Does Alzheimer’s disease represent an exaggeration of normal aging? Arch Neurol 42: 737 – 739

    PubMed  CAS  Google Scholar 

  • Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science 261: 921 – 923

    Article  PubMed  CAS  Google Scholar 

  • Hardy J, Mullan M, Chartier-Harlin MC (1991) Molecular classification of Alzheimer’s disease. Lancet 337: 1342

    Google Scholar 

  • Hyman BT, Van Hoesen GW, Damasio AR (1990) Memory-related neural systems in Alzheimer’s disease: an anatomic study. Neurology 40: 1721 – 1730

    PubMed  CAS  Google Scholar 

  • Jobst KA, Smith AD, Szatmari M, Esiri MM, Jaskowski A, Hindley N, McDonald B, Molyneux AJ (1994) Rapidly progressing atrophy of medial temporal lobe in Alzheimer’s disease. Lancet 343: 829 – 830

    Article  PubMed  CAS  Google Scholar 

  • KatzmanR, Terry R, DeTeresa R, Brown T, Davies P, Fuld P, Reubing X, Peck A (1988) Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques. Ann Neurol 23: 138 – 144

    Article  PubMed  CAS  Google Scholar 

  • Khachaturian ZS (1985) Diagnosis of Alzheimer’s disease. Arch Neurol 42: 1097 – 1105

    PubMed  CAS  Google Scholar 

  • West MJ, Gundersen HJG (1990) Unbiased stereological estimation of the number of neurons in the human hippocampus. J Compar Neurol 296: 1 – 22

    Article  CAS  Google Scholar 

  • West MJ, Coleman PD, Flood DG, Troncoso JC (1994) Differences in the pattern of hippocampal neuronal loss in normal aging and Alzheimer’s disease. Lancet 344: 769 – 772

    Article  PubMed  CAS  Google Scholar 

  • Zola-Morgan S, Squire LR, Amarai DG (1986) Human amnesia and the medial temporal region: Enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus. J Neurosci 6: 2950 – 2967

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nuerobiology, Institute Of Anatonmy, University of Aarhus, 8000, Aarhus C, Denmark

    M. J. West

Authors
  1. M. J. West
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. D. Coleman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. G. Flood
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. C. Troncoso
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Nuerology Service, Massachusetts General Hospital, Fruit Street, 02114, Boston, MA, USA

    B. T. Hayman M.D., Ph.D.

  2. Laboratoire de Neuropathologie R. Escourolle, Hôpital de La Salpêtrière, Blvd. de l’Hôpital, 75651, Paris Cedex 16, France

    C. Duyckaerts M.D., Ph.D.

  3. Fondation IPSEN, 24, rue Erlanger, 75651, Paris Cedex 16, France

    Y. Christen Ph.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

West, M.J., Coleman, P.D., Flood, D.G., Troncoso, J.C. (1997). Is Alzheimer’s Disease Accelerated Aging? Different Patterns of Age and Alzheimer’s Disease-Related Neuronal Losses in the Hippocampus. In: Hayman, B.T., Duyckaerts, C., Christen, Y. (eds) Connections, Cognition and Alzheimer’s Disease. Research and Perspectives in Alzheimer’s Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60680-9_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-60680-9_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64504-4

  • Online ISBN: 978-3-642-60680-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation