Skip to main content
SpringerLink
Log in

Monosialogangliosides and Nerve Growth Factor Stimulate Synthesis of Glycoproteins in Glioma Cells

  • Conference paper
Molecular Signaling and Regulation in Glial Cells

  • 98 Accesses

Abstract

The development of the neural cell phenotype is influenced by the genetic information contained within the nucleus, as well as by time-designated epigenetic contributions such as local modulation of the environment and cellular interactions with other developing cells and their cell surface signaling or secreted molecules. Differentiation is frequently accompanied by acquisition and modulation of cell surface constituents which permit both homotypic and heterotypic interactions between cells (5, 8, 20). Among these molecular constituents, glycoproteins (Gp)I are believed to provide the specificity required for cell-cell and cell-substrate recognition and to participate in the development of the neural phenotype.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Abbreviations

CNS:

central nervous system

DMEM:

Dulbecco’s modified Eagle medium

ECM:

extracellular matrix

EGF:

epidermal frowth factor

FGF:

fibroblast growth factor

Gg:

ganglioside

GD1a :

Gal[3-aNeuAc]b-3GaINacb-4Gal[3-lNeuAc]b-4Glc-Cer]

GT1b :

Gal[3-aNeuAc]b-3GaINacb-4Gal[3-lNeuAc-aNeuAc]b-4Glc-Cer]

GM1 :

Galb-3Gal Nacb-4Gal[3-aNeuAc]b-3GaINacb-4Gal[3-1NeuAc-aNeuAc]b-4Glc-Cer]

GM2 :

Galb-4Gal Nacb-4Gal[3-aNeuAc]b-3GaINacb-4Gal[3-1NeuAc-aNeuAc]b-4Glc-Cer]

GM3 :

Gal[3-aNeuAc]b-4Glc-Cer

MW:

molecular weight

NGF:

nerve growth factor

SDS-PAGE:

sodium dodecyl sulfate-polyacrylamide gel electropherosis

TCA:

trichloroacetic acid

References

  1. . Arenander, A.T. and DeVellis, J. (1980) Glial-released proteins in clonal cultures and their modulation by hydrocortisone. Brain Res. 200, 401–419.

    Article  PubMed  CAS  Google Scholar 

  2. Barde, Y.A., Lindsay, R.M., Monard, D. and Thoenen, H. (1978) New factor released by cultured glioma cells supporting survival and growth of sensory neurons. Nature 274, 20.

    Article  Google Scholar 

  3. Facci, L., Skaper, S.D., Favaron, M. and Leon, A. (1988) A role of gangliosides in astroglial cell differentiation in vitro. J. Cell Biol. 106, 821–828

    Article  PubMed  CAS  Google Scholar 

  4. Ferrari, G., Fabris, M. and Gorio, A. (1983) Gangliosides enhance neurite outgrowth in PC12 cells. Dev. Brain Res. 8, 215–222.

    Article  CAS  Google Scholar 

  5. Grumet, M., Hoffman, S., Crossin, K.L. and Edelman, G.M. (1985) Cytotactin, an extracellular matrix protein of neural and nonneural tissues that mediates neuron-glia interaction. Proc. Natl. Acad. Sci. USA 82, 8075–8079.

    Article  PubMed  CAS  Google Scholar 

  6. Hanai, N., Dohi, T., Nores, G.A. and Hakomori, S. (1988) A novel ganglioside, de-N-acetyl-GM3 (II3NeuNF2LacCer), acting as a strong promoter for epidermal growth factor receptor kinase and as a stimulator for cell growth. J. Biol. Chem. 263, 6296–6301.

    PubMed  CAS  Google Scholar 

  7. Hefti, F., Hartikka, J. and Frick, W. (1985) Gangliosides alter morphology and growth of astrocytes and increase the activity of choline acetyltranferase in cultures of dissociated septal cells. J. Neurosci. 5, 2086–2094.

    PubMed  CAS  Google Scholar 

  8. Hoffman, S., Crossin, K.L. and Edelman, G.M. (1988) Molecular forms, binding functions, and developmental expression pattern of cytotactin and cytotactin-binding proteoglycan, an interactive pair of extracellular matrix molecules. J. Cell Biol. 106, 519–532.

    Article  PubMed  CAS  Google Scholar 

  9. Kreutter, D., Kim, J.Y.H., Goldenring, J.R, Rasmussen, H., Ukomadu, C., De Lorenzo, R.J. and Yu, R.K. (1987) Regulation of protein kinase C activity by gangliosides. J. Biol. Chem. 262, 1633–1637.

    PubMed  CAS  Google Scholar 

  10. Kumar, S., Huber, J., Pena, L.A., Perez-Polo, J.R., Werrbach-Perez, K. and DeVellis, J. (1990) mAb 217C recognizes NGFR in C6 glioma cells. Proc. ASN 21, 158.

    Google Scholar 

  11. Leon, A., Facci, L., Toffano, G., Sonnino, S. and Tettamanti, G. (1981) Activation of (Na+,K+)-ATPase by nanomolar concentrations of GMj ganglioside. J. Neurochem. 37, 350–357.

    Article  PubMed  CAS  Google Scholar 

  12. . Massa, P.R. (1993) Specific suppression of major histocompatibility complex class I and class II genes in astrocytes by brain-enriched gangliosides. J. Exp. Med. 178, 1357–1363.

    Article  PubMed  CAS  Google Scholar 

  13. Murphy, R.A., Oger, J., Saide, J.D., Blanchard, M.H., Arnason, B.G.W., Hogan, C., Pantazis, N.J. and Young, M. (1977) Secretion of nerve growth factor by central nervous system glioma cells in culture. J. Cell Biol. 72, 769–773.

    Article  PubMed  CAS  Google Scholar 

  14. Nagai, Y. and Tsuji S. (1988) Cell biological significance of gangliosides in neural differentiation and development: Critique and proposals. In R.W. Ledeen, E.L. Hogan, G. Tettamanti, A.J. Yates and R.K. Yu (eds.), New Trends in Ganglioside Research, Vol. 14, Liviana Press, Padova, pp. 329–350.

    Google Scholar 

  15. . Nakaoka, T., Tsuji, S. and Nagai, Y. (1992) Bimodal regulation of protein phosphorylation by a ganglioside in rat brain membrane. J. Neurosci. Res. 31, 724–730.

    Article  PubMed  CAS  Google Scholar 

  16. Rabin, S., Colangelo, A.M. and Mocchetti, I. (1994) GMj ganglioside activates the high affinity nerve growth factor receptor trkA. Soc. Neurosci. Abstr. 20, 23.18

    Google Scholar 

  17. Richter-Landsberg, C., Lee, V.M., Salton, S.R.J., Shelanski, M.L. and Greene, L.A. (1984) Release of the NILE and other glycoproteins from cultured PC 12 rat pheochromocytoma cells and sympathetic neurons. J. Neurochem. 43, 841–848.

    Article  PubMed  CAS  Google Scholar 

  18. . Rybak, S., Ginzburg, I. and Yavin, E. (1983) Gangliosides stimulate neurite outgrowth and induce tubulin mRNA accumulation in neural cells. Biochem. Biophys. Res. Commun. 116, 974–980.

    Article  PubMed  CAS  Google Scholar 

  19. Schengrund, C.-L. (1995) Evidence that molecules on the surface of one cell can adhere to the oligosaccharide portion of gangliosides on the surface of another cell. Biol. Signals 4, 1–13.

    Article  PubMed  CAS  Google Scholar 

  20. Schubert, D. and LaCorbiere, M. (1982) The specificity of extracellular glycoprotein complexes in mediating cellular adhesion. J. Neurosci. 2, 82–89.

    PubMed  CAS  Google Scholar 

  21. . Skaper, S.D., Facci, L., Rudge, J., Katoh-Semba, R., Manthorpe, M. and Varon, S. (1986) Morphological modulation of cultured rat brain astroglial cells: Antagonism by ganglioside GM1. Dev. Brain Res. 25, 21–31.

    Article  CAS  Google Scholar 

  22. Tsuji, S., Yamashita, T., Matsuda, Y. and Nagai, Y. (1992) A novel glycosignalling system: GQ1b-dependent neuritogenesis of human neuroblastoma cell line, GOTO, is closely associated with GQ1b-dependent ecto-type protein phosphorylation. Neurochem. Int. 21, 549–554.

    Article  PubMed  CAS  Google Scholar 

  23. Vinores, S.A. (1983) Increased adhesion response of anaplastic glioma cells to nerve growth factor and the presence of specific receptors. J. Neurosci. Res. 10, 381–395.

    Article  PubMed  CAS  Google Scholar 

  24. Westermann, R, Hardung, M., Meyer, D.K., Ehrhard, P., Otten, U. and Unsicker, K. (1988) Neuronotrophic factors released by C6 glioma cells. J. Neurochem. 50, 1747–1758.

    Article  PubMed  CAS  Google Scholar 

  25. Yates, A.J., Walters, J.D., Wood, C.L. and Johnson, J.D. (1989) Ganglioside modulation of cyclic AMP-dependent kinase and cyclic nucleotide phosphodiesterase in vitro. J. Neurochem. 53, 162–167.

    Article  PubMed  CAS  Google Scholar 

  26. Yavin, E. and Yavin, Z. (1974) Attachment and culture of dissociated cells from rat embryo cerebral hemispheres on polylysine-coated surface. J. Cell Biol. 62, 540–546.

    Article  PubMed  CAS  Google Scholar 

  27. Yavin, E. and Yavin, Z. (1979) Ganglioside profiles during neural tissue development: Acquisition in the prenatal rat brain and cerebral cell cultures. Dev. Neurosci. 2, 25–37.

    Article  CAS  Google Scholar 

  28. Yavin, E., Richter-Landsberg, C., Duksin, D. and Yavin, Z. (1984) Tunicamycin blocks neuritogenesis and glucosamine labeling of gangliosides in developing cerebral neuron cultures. Proc. Natl Acad Sci. USA 81, 5638–5642.

    Article  PubMed  CAS  Google Scholar 

  29. Yavin, E., Hama, T., Gil, S. and Guroff, G. (1986) NGF and ganglioside stimulate release of glycoproteins in PC12 pheochromocytoma cells. J. Neurochem. 46, 794–803.

    Article  PubMed  CAS  Google Scholar 

  30. Yavin, E., Gil, S., Consolazione, A., dal Tosso, R. and Leon, A. (1987) Selective enhancement of tubulin gene expression and increase in oligo(dt) bound RNA in the rat brain after nigrostriatal pathway unilateral lesion and treatment with ganglioside. J. Neurosci. Res. 18, 615–621.

    Article  PubMed  CAS  Google Scholar 

  31. Yavin, E., Gabai, A. and Gil, S. (1991) Nerve growth factor mediates monosialoganglioside-induced release of fibronectin and Jl/tenascin from C6 glioma cells. J. Neurochem. 56, 105–112.

    Article  PubMed  CAS  Google Scholar 

  32. Yavin, Z. and Yavin, E. (1980) Survival and maturation of cerebral neurons on poly-L-lysine surfaces in the absence of serum. Dev. Biol. 75, 454–459.

    Article  PubMed  CAS  Google Scholar 

  33. Yim S-H., Yavin E., Hammer J.A. and Quarles, R.H. (1991) Exogenous GM3 ganglioside stimulates process formation and glycoprotein release by cultured bovine oligodendrocytes. J. Neurochem. 57, 2144–2147.

    Article  PubMed  CAS  Google Scholar 

  34. Yim, S.H., Farrer, R.G., Hammer, J.A., Yavin, E. and Quarles, R.H. (1994) Differentiation of oligodendrocytes cultured from developing rat brain is enhanced by exogenous GM3 ganglioside. J. Neurosci. Res. 38, 268–281

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurobiology, The Weizmann Institute of Science, 76100, Rehovot, Israel

    Ephraim Yavin

Authors
  1. Ephraim Yavin
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. FB Biologie/Chemie, Universität Osnabrück, Barbarastr. 11, D-49069, Osnabrück, Germany

    Gunnar Jeserich

  2. Max-Planck-Institut für Experimentelle Medizin, Hermann-Reinsstr. 3, D-37075, Göttingen, Germany

    Hans H. Althaus

  3. FB Biologie, Universität Oldenburg, Postfach 2503, D-26111, Oldenburg, Germany

    Christiane Richter-Landsberg

  4. Molekulare Neurobiochemie, Universität Bochum, Universitätsstr. 150, D-44801, Bochum, Germany

    Rolf Heumann

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Yavin, E. (1997). Monosialogangliosides and Nerve Growth Factor Stimulate Synthesis of Glycoproteins in Glioma Cells. In: Jeserich, G., Althaus, H.H., Richter-Landsberg, C., Heumann, R. (eds) Molecular Signaling and Regulation in Glial Cells. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60669-4_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-60669-4_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64501-3

  • Online ISBN: 978-3-642-60669-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation