Abstract
Nerves of the adult mammalian CNS do not regenerate successfully after axonal injury. After an initial degeneration injured axons start to regrow, but this regrowth ceases after a few hundred micrometers without traversing the lesion site. This failure of axonal regeneration is attributed mainly to the nonpermissive environment surrounding the axons. A great number of studies have shown that injured neurons are capable of regrowing to greater lengths if an appropriate environment is provided. Such a growth-promoting environment is created by peripheral nerve grafts or implanted Schwann cells (SC; for review see 10).
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© 1997 Springer-Verlag Berlin Heidelberg
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Stichel, C., Lips, K., Wunderlich, G., Muller, H.W. (1997). Schwann Cell Suspension Grafts Promote Reconstruction of Transected Postcommissural Fornix in the Adult Rat. In: Jeserich, G., Althaus, H.H., Richter-Landsberg, C., Heumann, R. (eds) Molecular Signaling and Regulation in Glial Cells. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60669-4_31
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DOI: https://doi.org/10.1007/978-3-642-60669-4_31
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