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The Effect of Myelin Disruption on Spinal Cord Regeneration

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Molecular Signaling and Regulation in Glial Cells

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Abstract

The adult central nervous system (CNS) of higher vertebrates has a very limited capacity for regeneration following injury. CNS regeneration in higher vertebrates is primarily restricted to monoaminergic fibres (7), unmyelinated cholinergic axons (7) primary olfactory axons (4), and neurosecretory fibres (14). With these exceptions, damage to the adult CNS most often results in aborted attempts at regeneration followed by degeneration (7, 45). However, some CNS axons will anatomically regenerate and make functional synaptic connections if peripheral nerve segments containing Schwann cells are grafted to a site of CNS injury (l, 13, 45). Similarly, axotomized CNS neurons will extend axons in vivo through implants of fetal (8, 9, 34), or genetically modified (20, 65) CNS tissue. These findings indicate that adult CNS neurons retain intrinsic growth programs which enable long-distance axonal regeneration in the presence of a favorable extraneuronal environment. Nevertheless, the intrinsic neuronal determinants of regeneration may differ in distinct populations of CNS neurons (19,35,63).

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Authors and Affiliations

  1. MRC Cambridge Centre for Brain Repair and Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge, UK, CB2 2PY

    Hans S. Keirstead

  2. Department of Zoology Anatomy and Surgery, University of British Columbia, Vancouver, BC, Canada, V6T 1Z4

    John D. Steeves

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  1. Hans S. Keirstead
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Editors and Affiliations

  1. FB Biologie/Chemie, Universität Osnabrück, Barbarastr. 11, D-49069, Osnabrück, Germany

    Gunnar Jeserich

  2. Max-Planck-Institut für Experimentelle Medizin, Hermann-Reinsstr. 3, D-37075, Göttingen, Germany

    Hans H. Althaus

  3. FB Biologie, Universität Oldenburg, Postfach 2503, D-26111, Oldenburg, Germany

    Christiane Richter-Landsberg

  4. Molekulare Neurobiochemie, Universität Bochum, Universitätsstr. 150, D-44801, Bochum, Germany

    Rolf Heumann

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© 1997 Springer-Verlag Berlin Heidelberg

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Keirstead, H.S., Steeves, J.D. (1997). The Effect of Myelin Disruption on Spinal Cord Regeneration. In: Jeserich, G., Althaus, H.H., Richter-Landsberg, C., Heumann, R. (eds) Molecular Signaling and Regulation in Glial Cells. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60669-4_21

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  • DOI: https://doi.org/10.1007/978-3-642-60669-4_21

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