Abstract
Conduction in myelinated axons depends upon both a highly heterogeneous distribution of ionic channels and on passive improvements in cable properties resulting from myelin formation. Under pathological conditions involving demyelination, action potential propagation can be delayed or blocked and recovery requires firstly removal of damaged myelin and secondly association with new glial cells. We have studied these processes extensively in the peripheral nervous system with both electrophysiological and immunocytochemical methods. We show that a complex series of events is initiated by Schwann cell adherence to demyelinated axons and that the recovery of conduction occurs in several stages.
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© 1997 Springer-Verlag Berlin Heidelberg
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Shrager, P., Novakovi, S.D. (1997). Ion Channel Reorganization During Remyelination. In: Jeserich, G., Althaus, H.H., Richter-Landsberg, C., Heumann, R. (eds) Molecular Signaling and Regulation in Glial Cells. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60669-4_12
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DOI: https://doi.org/10.1007/978-3-642-60669-4_12
Publisher Name: Springer, Berlin, Heidelberg
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