Abstract
Macroglial cells in the vertebrate gray matter are divided into two subtypes, the nonmyelinating astrocytes and the myelinating oligodendrocytes. To astrocytes a variety of functional roles have been ascribed including nutrition of neurons, uptake of amino acid neurotransmitters, and a contribution to extracellular potassium regulation. Furthermore, electrophysiological studies have revealed an astonishing repertoire of voltage-dependent and ligand-activated ion channels in cultured astrocytes as well as in vivo, not unlike those found in neurons (5). Oligodendrocytes, on the other hand, which enwrap axons with an electrically insulating membrane sheath, were originally considered as electrophysiologically inactive elements. Recent patch clamp studies, however, have shown a characteristic pattern of voltage-dependent ionic currents in this cell type, too.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Backus K.H., Kettenmann H., Schachner M. (1989) Pharmacological charac terisation of the glutamtate receptor in cultured trout astrocytes. J. Neurosci. Res. 22, 274–282.
Barres B.A., Chun L.L.Y., and Corey D.P. (1988) Ion channel expression by white matter glia: I. Type 2 astrocytes and oligodendrocytes. Glia 1, 10–30.
Barres B.A., Chun L.L.Y., and Corey D.P. (1989) Glial and neuronal forms of the voltage-dependent sodium channel: characterisation and cell-type distribution. Neuron 2, 1375–1388.
Barres B.A., Koroshetz, W.J., Swartz K.J., Chun L.L.Y., and Corey D.P. (1990) Ion channel expression by white matter glia: The 0-2A glial progenitor cell. Neuron 4, 507–524.
Barres B.A., Chun L.L.Y., and Corey D.P. (1990a) Ion channels in vertebrate glia. Annu. Rev. Neurosci. 13, 441–474.
Barres B.A., Koroshetz, W.J., Chun L.L.Y., and Corey D.P. (1990b) Ion channel expression by white matter glia: The type 1 astrocyte. Neuron 5, 527–544.
Blankenfeld G. and Kettenmann H. (1992) Glutamate and GABA receptors in vertebrate glial cells. Mol. Neurobiol. 5, 31–42.
Clark B. and Mobbs P. (1992) Transmitter-operated channels in rabbit retinal astrocytes studied in situ by whole-cell patch clamping. J. Neurosci. 12, 664–673.
Clasen T., Jeserich G., and Kriippel T. (1995) Glutamate-activated ionic currents in cultured astrocytes from trout: Evidence for the occurence of Non-N-Methyl-D-Aspartate receptors. J. Neurosci. Res. 40, 632–640.
Gard A.L. and Pfeifer S.E. (1989) Oligodendrocyte progenitors isolated directly from developing telencephalon at a specific phenotypic stage: myelinogenic potential in a defined environment. Development 106, 119–132.
Glassmeier G., Jeserich G., and KrUppel T. (1992) Voltage-dependent potassium currents in cultured trout oligodendrocytes. J. Neurosci. Res. 32, 301–309.
Glassmeier G., Jeserich G., and Kriippel T. (1994) Voltage-dependent sodium and potassium currents in cultured trout astrocytes. Glia 11, 245–254
Glassmeier G. and Jeserich G. (1995) Changes in ion channel expression during in vitro differentiation of trout oligodendrocyte precursor cells. Glia 15, 83–93.
Hamill O.P., Marty A., Neher E., Sakmann B., and Sigworth F. J. (1981) Improved patch-clamp techniques for high resolution current recording from cell and cell-free membrane patches. Pflugers Arch. 391, 85–100.
Howe J.R. and Ritchie J.M. (1990) Sodium currents in Schwann cells from myelinated and non-myelinated nerves of neonatal and adult rabbits. J. physiol. (London) 425, 169–210.
Jeserich G. and Waehneldt T.V. (1987) Antigenic sites common to major fish myelin glycoproteins (IP) and to major tetrapode PNS myelin glycoprotein P0 reside in amino acid chain. Neurochem. Res. 12, 821–825.
Jeserich G. and Rauen T. (1990) Cell cultures enriched in oligodendrocytes from the central nervous system of trout in terms of phenotypic expression exhibits parallels with cultured rat Schwann cells. Glia 3, 65–74.
Jeserich G., Muller A., and Jacque C. (1990a) Developmental expression of myelin proteins by oligodendrocytes in the CNS of trout. Dev. Brain Res. 51, 27–34.
Jeserich G. and Stratmann A. (1992) In vitro differentiation of trout oligoden drocytes: Evidance for an A2B5-positve origin. Dev. Brain Res. 67, 27–35.
Jeserich G., Strelau J., and Tonnies R. (1993) An immunomagnetic cell separation technique for isolating oligodendroglial progenitor cells of trout CNS. Neuroprotocols: A Comp. Meth. Neurosci. 2, 219–224.
Kolb H.A. (1990) Potassium channels in excitable and non-excitable cells. Rev. Physiol. Biochem. Pharmacol. 115, 51–91.
Nowak L., Ascher P., and Berwald-Netter Y. (1987) Ionic channels in mouse astrocytes in culture. J. Neurosci. 7, 101–109.
Raff M.C., Abney E., Cohen J., Lindsay R., and Noble M. (1983) Two types of astrocytes in cultures of developing rat white matter: differences in morphology, surface gangliosides and growth characteristics. J. Neurosci. 3, 1289– 1300.
Soliven B., Szuchet S., Arnason B.G.W., and Nelson D.J. (1988) Voltagegated potassium currents in cultured ovine oligodendrocytes. J. Neurosci. 8,2131–2141.
Sontheimer H. and Kettenmann H. (1988) Heterogenity of potassium currents in cultured oligodendrocytes. Glia 1, 415–420.
Sontheimer H., Kettenmann H., Backus K.H., and Schachner M. (1988) Glutamate opens Na+/K+ channels in cultured astrocytes. Glia 1, 328–336.
Sontheimer H., Trotter J., Schachner M., and Kettenmann H. (1989) Channel expression correlates with differentiation stage during the development of oligodendrocytes from their precursor cells in culture. Neuron 2, 1135–1145.
Sontheimer H., Ransom B.R., Cornell-Bell A.H., Black J.A., and Waxman S.G. (1991) Na+ current expression in rat hippocampal astrocytes in vitro: Alteration during development. J. Neurophysiol. 65, 3–19.
Sontheimer H., Ransom B.R., and Waxman S.G. (1992a) Different Na+ currents in PO and P7-derived hippocampal astrocytes in vitro: Evidance for a switch in Na+-channel expression in vivo. Brain. Res. 597, 24–29.
Sontheimer H. and Waxman S.G. (1992b) Ion channels in spinal cord astro cytes in vitro. II. Biophysical and pharmacological analysis of two Na+ current types. J. Neurophysiol. 68, 1001–1011.
Sontheimer H., Black J.A., Ransom B.R., and Waxman S. G. (1992c) Ion channels in spinal cord astrocytes in vitro. 1. Transient expression of high levels of Na+ and K+ channels. J. Neurophysiol. 68, 985–1000.
Sontheimer H. and Waxman S.G. (1993) Expression of voltage-activated ion channels by astrocytes and oligodendrocytes in the hippocampal slice. J. Neurophysiol. 70, 1863–1873.
Stiihmer W., Ruppersberg, J.P., Schroter K.H., Sakmann B., Stocker M., Giese K.P., Perschke A., Baumann A., and Pongs O. (1989) Molecular basis of functional derversity of voltage-gated potassium channels in mammalian brain. The EMBO Journal vol. 8 no. 11, 3225–3244.
Tse F.W., Fraser D.D., Duffy S., and Mac Vicar B.A. (1992) Voltage acti vated K+ currents in acutely isolated hippocampal astrocytes. J. Neurosci. 12, 1781–1788.
Usowicz M.M., Gallo V., and Cull-Candy S.G. (1989) Multiple conductance channels in type-2 cerebellar astrocytes activated by excitatory amino acids. Nature 339, 380–383.
Wilkin G.P., Mariott D.R. and Cholewinski A.J. (1990) Astrocyte heterogeneity. Trend Neurosci. 13, 43–46
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Rabe, H., Glassmeier, G., Nguyen, TD., Jeserich, G. (1997). Ion Channel Expression in Glial Cells from Trout Central Nervous System. In: Jeserich, G., Althaus, H.H., Richter-Landsberg, C., Heumann, R. (eds) Molecular Signaling and Regulation in Glial Cells. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60669-4_11
Download citation
DOI: https://doi.org/10.1007/978-3-642-60669-4_11
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-64501-3
Online ISBN: 978-3-642-60669-4
eBook Packages: Springer Book Archive