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Platelets and Their Factors pp 83–98Cite as

Platelet Aggregation

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 126))

Abstract

The formation of a platelet thrombus plays a crucial role in hemostasis and also in pathomechanisms of several arterial disorders, including stroke and myocardial infarction. The initial step in thrombus formation is the adhesion of platelets onto vascular subendothelial connective tissue exposed upon endothelial injury (see Chap. 3). Collagen and von Willebrand factor (vWF) are important constituents of the subendothelial matrix which mediate adhesion and subsequent activation of the platelets. Platelet activation allows interplatelet contact and the formation of platelet aggregates. In this chapter, the molecular mechanisms mediating platelet aggregation and the tests to assess this platelet function in vitro are summarized. In addition, recent progress in the selective inhibition of platelet aggregation as a therapeutical principle is addressed.

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Authors
  1. A. Ruf
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  2. M. M. Frojmovic
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  3. H. Patscheke
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Editors and Affiliations

  1. Institut für Pharmakologie, Freie Universität Berlin, Thielallee 69-73, 14195, Berlin, Germany

    Franz von Bruchhausen

  2. Institut für Klinische Biochemie und Pathobiochemie, Medinzinische Universitätsklinik, Josef-Schneider-Str. 2, 97080, Würzburg, Germany

    Ulrich Walter

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Ruf, A., Frojmovic, M.M., Patscheke, H. (1997). Platelet Aggregation. In: von Bruchhausen, F., Walter, U. (eds) Platelets and Their Factors. Handbook of Experimental Pharmacology, vol 126. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60639-7_4

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  • DOI: https://doi.org/10.1007/978-3-642-60639-7_4

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