Abstract
Reversible phosphorylation of proteins regulates a great number of functional responses within cells, including many of those associated with platelet activation. The importance of phosphorylation is emphasised by estimates that approximately one third of cellular proteins contain covalently bound phosphate and that between 2% and 3% of all eukaryotic genes encode for proteins involved in the regulation of protein phosphorylation (Hubbard and Cohen 1993; Hunter 1995). There may be as many as 2000 genes in the human genome encoding proteins involved in the regulation of protein de-phosphorylation, of which fewer that 10% have been cloned (Cohen 1993; Hunter 1995).
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Watson, S.P. (1997). Protein Phosphatases in Platelet Function. In: von Bruchhausen, F., Walter, U. (eds) Platelets and Their Factors. Handbook of Experimental Pharmacology, vol 126. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60639-7_14
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