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Protein Kinase C and Its Interactions with Other Serine-Threonine Kinases

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Platelets and Their Factors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 126))

Abstract

Despite the diversity of platelet agonists, ranging from soluble molecules that bind to receptors on the platelet surface to shear stress (Kroll et al. 1993) and various artificial surfaces (Ware et al. 1991), the changes in platelet function that they induce are stereotypical. These include cytoskeletal reorganization (shape change), conversion of the αIIb-β3 integrin complex to a ligand-binding form, release of contents from storage granules, and clot retraction. Moreover, the pathways leading to expression of these diverse functions involve the generation of second messengers in a pattern that is somewhat similar among the agonists (Ware and Coller 1994); these mediators in turn interact with intracellular effectors, of which the most widely studied are protein kinases, enzymes that transfer phosphoryl groups from ATP to an acceptor polypeptide substrate. Two general categories of protein kinases have been identified: those that mediate the phosphorylation of proteins on tyrosine residues and those that phosphorylate substrates on serine or threonine residues.

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Authors
  1. J. A. Ware
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  2. J. D. Chang
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Editors and Affiliations

  1. Institut für Pharmakologie, Freie Universität Berlin, Thielallee 69-73, 14195, Berlin, Germany

    Franz von Bruchhausen

  2. Institut für Klinische Biochemie und Pathobiochemie, Medinzinische Universitätsklinik, Josef-Schneider-Str. 2, 97080, Würzburg, Germany

    Ulrich Walter

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Ware, J.A., Chang, J.D. (1997). Protein Kinase C and Its Interactions with Other Serine-Threonine Kinases. In: von Bruchhausen, F., Walter, U. (eds) Platelets and Their Factors. Handbook of Experimental Pharmacology, vol 126. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60639-7_12

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  • DOI: https://doi.org/10.1007/978-3-642-60639-7_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64488-7

  • Online ISBN: 978-3-642-60639-7

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