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Suppressive Cellular and Molecular Activities in Maternofetal Immune Interactions; Suppressor Cell Activity, Prostaglandins, and Alpha-Fetoproteins

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Book cover Reproductive Immunology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 222))

Abstract

Pregnancy has been termed an immunological “paradox” because the fetoplacental unit –although genetically and antigenically alien to its mother–is usually accepted by her as a “semi-allograft”. Several models have been proposed to explain this apparent paradox. BILLINGHAM’S (1964) concept of the fetoplacental unit as a semi-allograft is still valid form a purely genetic point of view, but otherwise has some shortcomings. First, in contrast to a grafted organ, a fetal “graft’s” blood circulation is structurally separated from that of the mother by a barrier in humans consisting of trophoblastic cells, fetal capillary endothelium, and basal membranes with mesenchymal cells in between (see REDLINE, this volume).

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  1. The Karolinska Institute, Department of Immunology, Microbiology, Pathology and Infectious Diseases, Division of Pathology, Huddinge University Hospital, 141 86, Huddinge, Sweden

    L. B. Olding, N. Papadogiannakis & B. Barbieri

  2. Department of Microbiology and Immunology, McGill University, Montreal, 03A 2P4, Quebec, Canada

    R. A. Murgita

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  1. Department of Immunology, Microbiology, Pathology and Infectious Diseases Karolinska Institute Division of Pathology, F42 Huddinge University Hospital, Huddinge, S-141 86, Sweden

    Lars B. Olding M.D., Ph.D.

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Olding, L.B., Papadogiannakis, N., Barbieri, B., Murgita, R.A. (1997). Suppressive Cellular and Molecular Activities in Maternofetal Immune Interactions; Suppressor Cell Activity, Prostaglandins, and Alpha-Fetoproteins. In: Olding, L.B. (eds) Reproductive Immunology. Current Topics in Microbiology and Immunology, vol 222. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60614-4_8

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