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Stationäre Langzeitbehandlung mit Clozapin

  • Conference paper
Clozapin

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Zusammenfassung

Es wird ein Überblick von aktuellen Ergebnissen der stationären Langzeitbehandlung mit Clozapin gegeben. Dabei soll zu folgenden Fragen Stellung genommen werden:

  1. 1.

    Bei welchen psychischen Erkrankungen kann eine Langzeitbehandlung mit Clozapin indiziert sein?

  2. 2.

    Welchen therapeutischen Einfluß hat Clozapin auf die Negativsymptomatik?

  3. 3.

    Wie ist die therapeutische Wirksamkeit von Clozapin auf therapieresistente Schizophrenien?

  4. 4.

    Wie ist die rezidivprophylaktische Wirksamkeit von Clozapin für schizophrene Psychosen?

  5. 5.

    Wie sollte Clozapin im Rahmen einer Langzeitbehandlung dosiert werden und welcher Zusammenhang besteht zwischen Dosis und Plasmaspiegel?

  6. 6.

    Hat Clozapin einen Einfluß auf die Compliance?

  7. 7.

    Welche Probleme ergeben sich aus einer Kombinationstherapie von Clozapin mit anderen Psychopharmaka?

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Literatur

  • Ackenheil M, Brau H (1976) Antipsychotische Wirksamkeit im Verhältnis zum Plasmaspiegel von Clozapin. Arzneimittelforsch (Drug Res) 26:1156–1158

    CAS  Google Scholar 

  • Angst J, Stassen HH, Woggon B (1989) Effect of neuroleptics on positive and negative symptoms and the deficit state. Psychopharmacology 99:41–46

    Article  Google Scholar 

  • Bandelow B (1992) Clozapin (Leponex) in der Behandlung von schizoaffektiven Psychosen, manischen Syndromen und Schlafstörungen. In: Naber D, Müller-Spahn F (Hrsg) Clozapin - Pharmakologie und Klinik eines atypischen Neuroleptikums. Schattauer, Stuttgart New York S 57–62

    Google Scholar 

  • Banov MD, Zarate CA, Tohen M (1994) Clozapine therapy in refractory affective disorders: polarity predicts response in long-term follow-up. J Clin Psychiatry 55:295–300

    PubMed  CAS  Google Scholar 

  • Breier A, Buchmann RW, Kirkpatrick B et al. (1994) Effects of clozapine on positive and negative symptoms in outpatients with schizophrenia. Am J Psychiatry 151:20–26

    PubMed  CAS  Google Scholar 

  • Burchard JM (1992) Die Behandlung therapieresistenter Depressionen und blander Psychosen mit Clozapin (Leponex) In: Naber D, Müller-Spahn F (Hrsg) Clozapin - Pharmakologie und Klinik eines atypischen Neuroleptikums. Schattauer, Stuttgart New York S 63–69

    Google Scholar 

  • Caine ED, Polinsky RJ, Kartzinel R, Ebert MH (1979) The trial use of clozapine for ab-normal involuntary movement disorders. Am J Psychiatry 136:317–320

    PubMed  CAS  Google Scholar 

  • Claghorn J, Honigfeld G, Abuzzahab S et al. (1987) The risks and benefits of clozapine versus chlorpromazin. J Clin Psychopharmacol 7:377–384

    Article  PubMed  CAS  Google Scholar 

  • Classen W, Laux G (1988) Sensorimotor and cognitive performance of schizophrenic inpatients treated with haloperidol, flupenthixol, or clozapine. Pharmacopsychiatry 21:295–297

    Article  PubMed  CAS  Google Scholar 

  • Clozapine Study Group (1993) The safety and efficacy of clozapine in severe treat-ment-resistant schizophrenic patients in the UK. Br J Psychiatry 163:150–154

    Article  Google Scholar 

  • Cohen BM, Keck PE, Satlin A, Cole JO (1991) Prevalence and severity of akathisia in patients of clozapine. Psychiatry 29:1215–1219

    CAS  Google Scholar 

  • Cole JO, Gardos G, Tarsy D (1980) Drug trials in persistent dyskinesia. In: Fann WE, Smith RC, Davis JM (eds) Tardive dyskinesia, research and treatment. SP Medical and Scientific Books, New York, pp 419–427

    Google Scholar 

  • Deister A, Marneros A, Conrad C, Fischer J (1992) Clozapin (Leponex) bei therapieresistenten chronischen schizophrenen Psychosen. In: Naber D, Müller-Spahn F (Hrsg) Clozapin - Pharmakologie und Klinik eines atypischen Neuroleptikums. Schattauer, Stuttgart New York, S 37–42

    Google Scholar 

  • Dose M (1992) Clozapin (Leponex) in der Behandlung der Huntingtonschen Krankheit. In: Naber D, Müller-Spahn F (Hrsg) Clozapin - Pharmakologie und Klinik eines atypischen Neuroleptikums. Schattauer, Stuttgart New York, S 121–126

    Google Scholar 

  • Fischer PA (1992) Clozapin (Leponex) in der Behandlung des Parkinson-Tremors. In: Naher D, Müller-Spahn F (Hrsg) Clozapin - Pharmakologie und Klinik eines atypischen Neuroleptikums. Schattauer, Stuttgart New York, S 83–88

    Google Scholar 

  • Fischer-Cornellsen KA, Ferner UT (1976) An example of European multi-center trials: multispectral analysis of clozapine. Psychopharmacol Bull 12:34–39

    Google Scholar 

  • Frankenburg FR, Zanarini MC (1993) Clozapine treatment of borderline patients: a preliminary study. Compr Psychiatry 34:402–405

    Article  PubMed  CAS  Google Scholar 

  • Gaebel W, Klimke A, Klieser E (1994) Kombination von Clozapin mit anderen Psychopharmaka. In: Naber D, Müller-Spahn F (Hrsg) Clozapin-Pharmakologie und Klinik eines atypischen Neuroleptikums. Springer, Berlin Heidelberg New York, S 43–58

    Chapter  Google Scholar 

  • Gerlach J, Koppelhus P, Helweg E (1974) Clozapine und haloperidol in a single-blind cross-over trial: therapeutic and biochemical aspects in the treatment of schizophrenia. Acta Psychiatr Scand 50:410–424

    Article  PubMed  CAS  Google Scholar 

  • Goldberg TE, Greenberg RD, Griffin SF et al. (1993) The effect of clozapine on cognition and psychiatric symptoms in patients with schizophrenia. Br J Psychiatry 162:43–48

    Article  PubMed  CAS  Google Scholar 

  • Hagger C, Buckley P, Kenny JT, Friedman L, Ubogy D, Meltzer HY (1993) Improvement in cognitive functions and psychiatric symptoms in treatment-refractory schizophrenic patients receiving clozapine. Biol Psychiatry 34:702–712

    Article  PubMed  CAS  Google Scholar 

  • Haring C, Fleischhacker WW, Schett P et al. (1990) Influence of patient-related variables on clozapine plasma levels. Am J Psychiatry 147:1471–1475

    PubMed  CAS  Google Scholar 

  • Heinrich K, Klieser E, Lehmann E, Kinzler E, Hruschka H (1994) Risperidon versus clozapine in the treatment of schizophrenic patients with acute symptoms: a double blind randomized trial. Prog Neuro-Psychopharmacol Biol Psychiatry 18:129–137

    Article  CAS  Google Scholar 

  • Honigfeld G, Patin J, Singer J (1984) Clozapine: antipsychotic activity in treatment-resistent schizophrenics. Advan Ther 1:77–97

    Google Scholar 

  • Kane J, Honigfeld G, Singer J et al. (1988) Clozapine for the treatment-resistant schizophrenic: a double-blind comparison with chlorpromazine. Arch Gen Psychiatry 45:789–796

    Article  PubMed  CAS  Google Scholar 

  • Kane J, Safferman AZ, Pollack S et al. (1994) Clozapine, negative symptoms, and extrapyramidal side effects. J Clin Psychiatry 55:974–77

    Google Scholar 

  • Kirkegaard A, Hammershoj E, Ostergard P (1982) Evaluation of side effects due to Clozapine in long-term treatment of psychosis. Arzneimittelforsch 32:465–468

    PubMed  CAS  Google Scholar 

  • Klieser E, Schönell H (1990) Klinisch-pharmakologische Studie zur Behandlung schizophrener Minussymptomatik. In: Möller HJ, Pelzer E (Hrsg) Neuere Ansätze zur Diagnostik und Therapie schizophrener Minussymptomatik. Springer, Berlin New York, 5 217–222

    Chapter  Google Scholar 

  • Klieser E, Strauss WH, Lemmer W (1994) The tolerability and efficacy of the atypical neuroleptic remoxipride compared with clozapine and haloperidol in acute schizophrenia. Acta Psychiatr Scand 89 (Suppl 380):68–73

    Article  Google Scholar 

  • Klieser E, Heinrich K, Lehmann E (in press) Risperidone in comparison with various treatments of schizophrenia. In: Kane J, Möller HJ (eds) 5-HT 2-antagonism in schizophrenia. Raven Press, New York

    Google Scholar 

  • Klimke A, Klieser E (1995) Clozapin in der Rezidivprophylaxe. In: Naber D, Müller- Spahn F (Hrsg) Clozapin. Springer, Berlin Heidelberg New York Tokyo S 81–92

    Google Scholar 

  • Kronig MH, Munne RA, Szymanski S et al. (1995) Plasma clozapine levels and clinical response for treatment-refractory schizophrenic patients. Am J Psychiatry 152:179–182

    PubMed  CAS  Google Scholar 

  • Kuha S, Miettinen E (1986) Long-term effect of clozapine in schizophrenia: A retrosective study of 108 chronic schizophrenics treated with clozapine for up to 7 years. Psykiatrisk Tidsskrift 40:225–230

    Article  Google Scholar 

  • Kuoppasalmi K, Rimon R, Naukkarinen H et al. (1993) The use of clozapine in treatment-refractory schizophrenia. Schizophr Res 10:29–32

    Article  PubMed  CAS  Google Scholar 

  • Lieberman J, Saltz BL, Johns CA et al. (1991) The effects of clozapine on tardive dyskinesia. Brit J Psychiatry 158:503–510

    Article  CAS  Google Scholar 

  • Lindenmayer J-P, Grochowski S, Mabugat L (1994) Clozapine effects on positive and negative symptoms: A six-month trial in treatment-refractory schizophrenics. J Clin Psychopharmacology 14:20–204

    Article  Google Scholar 

  • Lindström LH (1988) The effect of long-term treatment of clozapine in schizophrenia: a retrospective study of 96 patients treated with clozapine for up to 13 years. Acta Psychiatr Scand 77:524–529

    Article  PubMed  Google Scholar 

  • McElroy SL, Dessain EC, Pope JG Jr et al. (1991) Clozapine in the treatment of psychotic mood disorder, schizoaffective disorder and schizophrenia. J Clin Psychiatry 52:411–414

    CAS  Google Scholar 

  • Meltzer HY (1986) Effect of neuroleptics on the schizophrenia syndrome. In: Dahl SG, Gram LF, Paul SM, Potter WZ (eds) Clinical pharmacology in psychiatry. Selectivity in psychotropic drug action - promises or problems. Springer, Berlin Heidelberg New York Tokyo, pp 255–265

    Google Scholar 

  • Meltzer HY (1995) Multiple-outcome criteria in schizophrenia: an overview of outcome with clozapine. Eur Psychiatry 10, Suppl 1:19–25

    Article  Google Scholar 

  • Miller DD, Perry PJ, Cadoret RJ, Andreasen NC (1994) Clozapine’s effect on negative symptoms in treatment-refractory schizophrenics. Compr Psychiatry 35:8–15

    Article  PubMed  CAS  Google Scholar 

  • Müller P, Herpertz R (1977) Zur Behandlung manischer Psychosen mit Clozapin. Fortschr Neurol Psychiatr 45:420–424

    Google Scholar 

  • Müller-Spahn F, Grohmann R, Modell S, Naber D (1992) Kombinationstherapie mit Clozapin (Leponex) - Wirkungen und Risiken. In: Naber D, Müller-Spahn F (Hrsg) Clozapin - Pharmakologie und Klinik eines atypischen Neuroleptikums. Schattauer, Stuttgart New York, S 161–169

    Google Scholar 

  • Naber D, Hackl C, Marzelli B et al. (1992) Zur subjektiven Wirkung von Clozapin (Leponex) im Vergleich zu typischen Neuroleptika. In: Naber D, Müller-Spahn F (Hrsg) Clozapin - Pharmakologie und Klinik eines atypischen Neuroleptikums. Schattauer, Stuttgart New York, S 171–177

    Google Scholar 

  • Naber D, Hippius H (1993) Indikation, Wirksamkeit und Verträglichkeit von Clozapin. Klinische Erfahrungen bei 1058 stationären Behandlungen. In: Naber D, Müller-Spahn F (Hrsg) Clozapin - Pharmakologie und Klinik eines atypischen Neuroleptikums. Neuere Aspekte der klinischen Praxis. Springer, Berlin Heidelberg New York Tokyo, S 91–101

    Google Scholar 

  • Peacock K, Gerlach J (1994) Clozapine treatment in Denmark: Concomitant psycho-tropic medication and hematologic monitoring in a system with liberal usage practics. J Clin Psychiatry 55:44–49

    PubMed  CAS  Google Scholar 

  • Perry PL, Miller D, Arndt S, Cadoret RJ (1991) Clozapine and norclozapine plasma concentrations and clinical response of treatment refractory schizophrenic patients. Am J Psychiatry 148:231–235

    PubMed  CAS  Google Scholar 

  • Pickar D, Owen R, Litman R et al. (1992) Clinical and biological response to clozapine in patients with schizophrenia. Arch Gen Psychiatry 49:345–353

    Article  PubMed  CAS  Google Scholar 

  • Potkin SG, Bera R, Gulasekaram B et al. (1994) Plasma clozapine concentrations predict clinical response in treatment-resistant schizophrenia. J Clin Psychiatry 55/9 (Suppl B):133–136

    Google Scholar 

  • Povlsen UJ, Noring U, Fog R et al. (1985) Tolerability and therapeutic effect of clozapine: a retrospective investigation of 216 patients treated with clozapine for up to 12 years. Acta Psychiatr Scand 71:176–185

    Article  Google Scholar 

  • Quadbeck H, Klieser E, Schönell H (1993) Combined treatment with clozapine and high potency neuroleptic drugs in therapy resistant psychoses as ultima ratio. Pharmacopsychiatry 26:188

    Google Scholar 

  • Rohde A, Adomeit A, Rao ML, Marneros A (1993) Clozapine: treatment response, side effects and serum neuroleptic activities in treatment refractory and in neurolepticintolerant patients. Pharmacopsychiatry 26:191

    Google Scholar 

  • Saffermann AZ, Lieberman JA, Pollack S, Kane JM (1993) Akathisia and clozapine treatment. J Clin Psychopharmacol 13:286–287

    Article  Google Scholar 

  • Shopsin B, Klein H, Aaronson M, Collora M (1979) Clozapine, chlorpromazine and placebo in newly hospitalized acutely schizophrenic patients. Arch Gen Psychiatry 36:657–664

    Article  PubMed  CAS  Google Scholar 

  • Simpson GM, Lee JH, Shrivastava RK (1978) Clozapine in tardive dyskinesia. Psycho-pharmacology 56:75–80

    CAS  Google Scholar 

  • Small JG, Milstein V, Marhenke JD (1987) Treatment outcome with clozapine in tardive dyskinesia neuroleptic sensitivity and treatment-resistant psychosis. J Clin Psychiatry 48:263–267

    PubMed  CAS  Google Scholar 

  • Szymanski S, Masiar S, Mayerhoff D, Loebel A, Geisler S, Pollack S, Kane J, Lieberman J (1994) Clozapine response in treatment-refractory first-episode schizophrenia. Soc Biol Psychiatry 35:278–280

    Article  CAS  Google Scholar 

  • Tandon R, Goldman R, DeQuardo JR, Goldman M, Perez M, Jibson M (1993) Positive and negative symptoms covary during clozapine treatment in schizophrenia. J Psychiatr Res 27/4:341–347

    Article  Google Scholar 

  • Tegeler J (1992) Clozapin (Leponex) und Spätdyskinesien. In: Naber D, Müller-Spahn F (Hrsg) Chlozapin - Pharmakologie und Klinik eines atypischen Neuroleptikums. Schattauer, Stuttgart New York S 71–88

    Google Scholar 

  • Weller M, Kornhuber J (1992) Differentielle Neurolepsie bei schizophrenen Psychosen im Wochenbett: Vorteile des atypischen Neuroleptikums Clozapin. Nervenarzt 63:440–441

    PubMed  CAS  Google Scholar 

  • Woggon B, Angst J (1976) Einzelne Aspekte der Behandlung mit Depotneuroleptika. In: Huber G (Hrsg) Therapie, Rehabilitation und Prävention schizophrener Erkrankungen. 3. Weissenauer Schizophreniesymposium, Lübeck-Travemünde. Schattauer, Stuttgart, S 191–200

    Google Scholar 

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Authors
  1. J. Tegeler
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Editors and Affiliations

  1. Psychiatrische und Nervenklinik, Universitätskrankenhaus Eppendorf, Universität Hamburg, Martinistraße 52, D-20246, Hamburg, Germany

    D. Naber  & F.-G. Pajonk  & 

  2. Psychiatrische Universitätsklinik Basel, Wilhelm-Klein-Straße 27, CH-4025, Basel, Schweiz

    F. Müller-Spahn

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© 1997 Springer-Verlag Berlin Heidelberg

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Tegeler, J. (1997). Stationäre Langzeitbehandlung mit Clozapin. In: Naber, D., Müller-Spahn, F., Pajonk, FG. (eds) Clozapin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60551-2_1

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  • DOI: https://doi.org/10.1007/978-3-642-60551-2_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-61691-7

  • Online ISBN: 978-3-642-60551-2

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