Summary
Following cold lesion of rat brain cortex, the time course of regional cerebral protein synthesis (CSP) and cerebral calcium uptake (CCU) was assessed in the same animal using [3H]leucine and 45CaCl by means of double tracer autoradiography. Various relationships between protein metabolism and tissue calcium homeostasis could be identified. In primary lesion sites, an enormous [45Ca]CCU at variable 3H-labeled tissue radioactivities indicated irreversible tissue damage. In cortex remote to the ipsilateral lesion, a transient rise in CPS was observed 2–4 days after onset of the cortical lesion without accompanying changes in CCU. In corticothalamic projection sites of the cortical lesion, however, CPS remained suppressed throughout 1–7 days post lesion with regional CCU values increasing significantly at 7 days after cold lesion of the cortex. Our results indicate that in the remote surrounding of a cortex lesion, a significant degree of cortical protein synthesis is associated with the survival and/or reorganization of neurons and/or glial cells, whereas delayed tissue damage in thalamic projection areas of the lesion site seems to be related to the persistent suppression of protein synthesis.
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Mies, G. et al. (1997). Modulation of Protein Synthesis and Calcium Uptake Following Traumatic Lesion of Rat Brain Cortex. In: Ito, U., Kirino, T., Kuroiwa, T., Klatzo, I. (eds) Maturation Phenomenon in Cerebral Ischemia II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60546-8_22
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DOI: https://doi.org/10.1007/978-3-642-60546-8_22
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