Skip to main content

Pathomechanismen kutaner paraneoplastischer Erkrankungen

  • Conference paper

Part of the book series: Fortschritte der praktischen Dermatologie und Venerologie ((DERMATOLOGIE,volume 15))

Zusammenfassung

Paraneoplastische Erkrankungen sind Krankheitsbilder, die überdurchschnittlich häufig mit malignen internen Erkrankungen assoziiert sind, diesen in ihrer klinischen Manifestation zeitlich vorausgehen können und nach erfolgreicher Therapie des malignen Tumors wieder abheilen [12, 15]. Im Bereich der Dermatologie kommen den paraneoplastischen Erkrankungen daher Markerfunktionen für die frühzeitige Erkennung eines malignen Tumors sowie möglicher Rezidive zu. In einzelnen Fällen gestattet das paraneoplastische Syndrom sogar die spezifische Diagnose des zugrundeliegenden Tumors, wie beim nekrolytischen migratorischen Erythem, dem in den meisten Fällen ein Glukagonom zugrundeliegt.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Accili D, Barbetti F, Cama A, Kadowaki H, Kadowaki T, Imano E, Levy-Toledano R, Taylor SI (1992) Mutations in the insulin receptor gene in patients with genetic syndromes of insulin resistance and acanthosis nigricans. J Invest Dermatol 98: 77–81

    Article  Google Scholar 

  2. Anhalt GJ, Kim SC, Stanley JR, Korman NJ, Jabs DA, Kory M, Izumi H, Ratrie H, Mutasim D, Ariss-Abdo L, Labib RS (1990) Paraneoplastic pemphigus. An autoimmune mucocutaneous disease associated with neoplasia. N Engl J Med 323: 1729–1735

    Article  CAS  PubMed  Google Scholar 

  3. Bolognia JL, Brewer YP, Cooper DL (1991) Bazex syndrome (acrokeratosis paraneoplastica). An analytical review. Medicine 70: 269–280

    Article  CAS  PubMed  Google Scholar 

  4. Breathnach SM, Wilkinson JD, Black MM (1982) Erythema gyratum repens-like figurate eruption in bullous pemphigoid. Clin Exp Dermatol 7: 401–406

    Article  CAS  PubMed  Google Scholar 

  5. Breathnach SM, Wells GC (1980) Acanthosis palmaris: tripe palms. A distinctive pattern of palmar keratoderma frequently associated with internal malignancy. Clin Exp Dermatol 5: 181–189

    Article  CAS  PubMed  Google Scholar 

  6. Chan LS, Hanson CA, Cooper KD (1991) Concurrent eosinophilic fasciitis and cutaneous T cell lymphoma. Eosinophilic fasciitis as a paraneoplastic syndrome of T-cell malignant neoplasms? Arch Dermatol 127: 862–865

    Article  CAS  PubMed  Google Scholar 

  7. Cohen PR, Talpaz M, Kurzrock R (1988) Malignancyassociated Sweets syndrome: review of the world literature. J Clin Oncol 6: 1889–1897

    Google Scholar 

  8. Cruz PD, Hud AH (1992) Excess insulin binding to insulin-like growth factor receptors: proposed mechanism for acanthosis nigricans. J Invest Dermatol 98: 82–85

    Article  Google Scholar 

  9. Engelmann L, Bonmann H, Kunze J, Haneke E (1991) Erythema necrolyticum migrans — Glukagonom-Syndrom. Akt Dermatol 17: 11–17

    Google Scholar 

  10. Flier JS, Usher P, Moses AC (1986) Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts. Proc Natl Acad Sci USA 83: 664–668

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Harper PS, Harper PJM, Howel-Evans AW (1970) Carcinoma of the oesophagus with keratosis palmaris et plantaris (tylosis): a study of two families. Quart J Med New Ser 39: 317–333

    CAS  Google Scholar 

  12. Herzberg JJ (1990) Paraneoplastische Syndrome in der Dermatologie. Kutane Paraneoplasien. Internist 31: 505–512

    CAS  PubMed  Google Scholar 

  13. Jemec GBE (1986) Hypertrichosis lanuginosa acquisita: Report of a case and review of the literature. Arch Dermatol 122: 805–808

    Article  CAS  PubMed  Google Scholar 

  14. Kasper CS, McMurry K (1991) Necrolytic migratory erythema without glucagonoma versus canine superficial necrolytic dermatitis: is hepatic impairment a clue to pathogenesis? J. Am Acad Dermatol 25: 534–541

    Article  CAS  PubMed  Google Scholar 

  15. Kaufmann R (1996) Paraneoplastische Erkrankungen am Hautorgan. Onkologie (im Druck)

    Google Scholar 

  16. Lawrence N, Rietschel RL, Butcher RB (1990) A palmar dermatosis linked to occult carcinoma of the upper thorax, head and neck: Bazexs syndrome and tripe palms. Laryngoscope 100: 1323–1325

    Article  CAS  PubMed  Google Scholar 

  17. Mirsa P, Nickoloff BJ, Morhenn VB, Hintz RL, Rosenfeld RG (1986) Characterization of insulin-like growth factor/somatomedin C receptors on human keratinocyte monolayers. J Invest Dermatol 87: 264–267

    Article  Google Scholar 

  18. Oursler JR, Labib RS, Ariss-Abdo L, Burke T, O’Keefe EJ, Anhalt GJ (1992) Human autoantibodies against desmoplakins in paraneoplastic pemphigus. J Clin Invest 89: 1775–1782

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  19. Parnell DD, Johnson SAM (1969) Tylosis palmaris et plantaris: its occurrence with internal malignancy. Arch Dermatol 100: 7–9

    Article  CAS  PubMed  Google Scholar 

  20. Rappersberger K, Wolff-Schreiner E, Konrad K, Wolff K (1987) Das Glukagonom-Syndrom. Hautarzt 38: 589–598

    CAS  PubMed  Google Scholar 

  21. Skolnick M, Mainman ER (1975) Erythema gyratum repens with metastatic adenocarcinoma. Arch Dermatol 111: 227–229

    Article  CAS  PubMed  Google Scholar 

  22. Sterry W, Merk H (1991) Checkliste Dermatologie und Venerologie. Thieme, Stuttgart

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Sterry, W. (1997). Pathomechanismen kutaner paraneoplastischer Erkrankungen. In: Plewig, G., Przybilla, B. (eds) Fortschritte der praktischen Dermatologie und Venerologie. Fortschritte der praktischen Dermatologie und Venerologie, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60534-5_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-60534-5_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64448-1

  • Online ISBN: 978-3-642-60534-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics