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Genetic Instability and Tumorigenesis pp 5–18Cite as

Genomic Stability and Instability: A Working Paradigm

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 221))

Abstract

Nearly a century of scientific inquiry into the nature of mutation has offered an exciting glimpse of the forces that cause mutation and drive evolution. New concepts make us realize the magnitude of the challenge of duplicating and distributing an accurate copy of the genome each time a cell divides. For each of the 1016 somatic cell divisions that occur in a human lifetime, each copy of the genome must contain an intact sequence of some 3 billion nucleotide base pairs, and each daughter cell must receive the correct number of the 46 chromosomes into which the instruction book of life is parceled. The challenging task of accurate DNA replication and distribution must be accomplished while the cell is under constant attack by forces that damage DNA.

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Authors and Affiliations

  1. Department of Pathology C7804, Jake Gittlen Cancer Research Institute, Adjunct, Department of Biochemistry and Molecular Biology, The Pennsylvania State College of Medicine, Hershey, PA, 17033, USA

    K. C. Cheng

  2. Department of Pathology SM-30 and Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA

    L. A. Loeb

Authors
  1. K. C. Cheng
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  2. L. A. Loeb
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Editor information

Editors and Affiliations

  1. Johns Hopkins Hospital, Ross 345, 720 Rutland Avenue, Baltimore, MD, 21205, USA

    Michael B. Kastan M.D., Ph.D.

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© 1997 Springer-Verlag Berlin Heidelberg

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Cheng, K.C., Loeb, L.A. (1997). Genomic Stability and Instability: A Working Paradigm. In: Kastan, M.B. (eds) Genetic Instability and Tumorigenesis. Current Topics in Microbiology and Immunology, vol 221. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60505-5_2

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  • DOI: https://doi.org/10.1007/978-3-642-60505-5_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64434-4

  • Online ISBN: 978-3-642-60505-5

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