Abstract
The TEL gene, originally cloned by virtue of involvement in the t(5;12) chromosomal translocation associated with chronic myelomonocytic leukemia (CMML), has a remarkable capacity to contribute to the pathogenesis of human leukemias: (1) TEL has been implicated in both myeloid and lymphoid leukemias, acute and chronic leukemias, and leukemias of both pediatric and adult populations; (2) TEL can contribute either its DNA binding domain or a putative helix-loop-helix (HLH) domain to fusion proteins, and (3) TEL has been associated with a surprising variety of fusion partners in human leukemias, including genes for transcription factors, receptor and non-receptor tyrosine kinases, and putative transcriptional activating domains. In addition, recent evidence suggests that loss of function of TEL may also contribute to pathogenesis of malignancy. In this report, the diverse molecular genetic mechanisms of leukemogenesis mediated by the TEL gene will be discussed.
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© 1997 Springer-Verlag Berlin Heidelberg
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Golub, T.R., Barker, G.F., Stegmaier, K., Gilliland, D.G. (1997). The TEL Gene Contributes to the Pathogenesis of Myeloid and Lymphoid Leukemias by Diverse Molecular Genetic Mechanisms. In: Rauscher, F.J., Vogt, P.K. (eds) Chromosomal Translocations and Oncogenic Transcription Factors. Current Topics in Microbiology and Immunology, vol 220. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60479-9_5
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DOI: https://doi.org/10.1007/978-3-642-60479-9_5
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