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Transcription Factors of the bHLH and LIM Families: Synergistic Mediators of T Cell Acute Leukemia?

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Chromosomal Translocations and Oncogenic Transcription Factors

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 220))

Abstract

Patients with T cell acute lymphoblastic leukemia (T-ALL) often harbor tumor-specific chromosome translocations in their malignant cells (reviewed by Raimondi 1993). In an effort to understand the etiology of T-ALL, many investigators have sought to identify the genes that are altered as a consequence of these chromosomal defects (Rabbitts 1994). To date these studies have uncovered nine presumptive proto-oncogenes, each of which can be activated in T-ALL cells by aberrant juxtaposition with the T cell receptor sequences on chromosomes 7 or 14 (Hwang and BAER 1995). For instance, the (8;14) (q24;q11) translocation serves to deregulate the MYC gene on chromosome 8 by recombining it with the T cell receptor α/δ chain locus on chromosome 14. The various proto-oncogenes implicated in T-ALL are listed in Table 1, along with the major chromosome translocations that are responsible for their activation.

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Author information

Authors and Affiliations

  1. Molecular Immunology Center, Department of Microbiology, UT Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd., Dallas, TX, 75235-9140, USA

    R. Baer & L.-Y. Hwang

  2. Molecular Immunology Center, Department of Pediatrics, UT Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd., Dallas, TX, 75235-9140, USA

    R. O. Bash

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  1. R. Baer
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  2. L.-Y. Hwang
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  3. R. O. Bash
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Editor information

Editors and Affiliations

  1. The Wistar Institute, 3601 Spruce Street, 19104-4268, Philadelphia, Pennsylvania, USA

    Frank J. Rauscher III Ph.D. (Associate Professor Chair, Molecular Genetics Program) (Associate Professor Chair, Molecular Genetics Program)

  2. Division of Oncovirology, BCC 239 Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, California, USA

    Peter K. Vogt Ph.D.

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© 1997 Springer-Verlag Berlin Heidelberg

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Baer, R., Hwang, LY., Bash, R.O. (1997). Transcription Factors of the bHLH and LIM Families: Synergistic Mediators of T Cell Acute Leukemia?. In: Rauscher, F.J., Vogt, P.K. (eds) Chromosomal Translocations and Oncogenic Transcription Factors. Current Topics in Microbiology and Immunology, vol 220. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60479-9_4

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  • DOI: https://doi.org/10.1007/978-3-642-60479-9_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64424-5

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