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Implications of the Glucokinase Glucose Sensor Paradigm for Pancreaticβ-Cell Function

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Contributions of Physiology to the Understanding of Diabetes

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Abstract

The β-cell glucokinase glucose sensor component of the feedback loops which regulate blood sugar is the primary topic of this chapter. This special aspect of the system should be viewed within the broader context of accepted tenets of blood sugar control: Normal pancreatic β-cell function is central to glucose homeostasis; precisely regulated glucose metabolism of the β-cells is required for the glucostat function of these cells; the glucokinase glucose sensor paradigm is the key to understanding β-cell glucose metabolism and stimulus secretion coupling; the insulin receptor and its signalling pathways and hormonal as well as autonomic counter regulatory processes complete the multicomponent feedback system that maintains glucose homeostasis.

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Authors
  1. F. M. Matschinsky
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Editors and Affiliations

  1. Fondation pour Recherches Médicales Faculté de Médecine, Université de Genève, 64, Avenue dela Roseraie, 1211, Genève 4, Switzerland

    Gaston R. Zahnd

  2. Division de Biochimie clinique et de Diabétologie expérimentale, Centre Médical Universitaire, 1211, Genève 4, Switzerland

    Claes B. Wollheim

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© 1997 Springer-Verlag Berlin Heidelberg

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Matschinsky, F.M. (1997). Implications of the Glucokinase Glucose Sensor Paradigm for Pancreaticβ-Cell Function. In: Zahnd, G.R., Wollheim, C.B. (eds) Contributions of Physiology to the Understanding of Diabetes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60475-1_5

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  • DOI: https://doi.org/10.1007/978-3-642-60475-1_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64422-1

  • Online ISBN: 978-3-642-60475-1

  • eBook Packages: Springer Book Archive

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