Abstract
Kupffer’s cell sarcoma usually consists of numerous small nodules (1–5 mm) randomly distributed throughout the liver (Chopra et al. 1979; Ford and Becker 1982). The lesions usually are irregular in shape and frequently have indistinct borders. On cut surface, the color is a homogeneous gray-white, although the tissue may be discolored by necrosis and hemorrhage in large lesions.
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References
Chopra P, Manga A, Nayak NC (1979) Kupffer cell sarcoma in rats after exposure to small doses of dimethylnitrosamine and N-2-acetylaminofluorene during hepatic regeneration. JNCI 62:1089–1095
Ford RJ, Becker FF (1982) The characterization of trypan blue-induced tumors in Wistar rats. Am J Pathol 106:326–331
Gillman T, Hallowes RC (1972) Ultrastructural and histochemical observations on a transplantable reticuloendothelial tumor in rats. Cancer Res 32:2383–2392
Gillman T, Kinns M, Cross RM (1969) Hodgkin’s disease: a possible experimental model in rats. Lancet 2:1421–1422
Gillman T, Kinns AM, Hallowes RC, Lloyd JB (1973) Malignant lymphoreticular tumors induced by trypan blue and transplanted in inbred rats. JNCI 50:1179–1193
Institute of Laboratory Animal Resources, National Research Council (1980) Histologic typing of liver tumors of the rat. JNCI 64:179–206
Knook DL, Wisse E (eds) (1982) Sinusoidal liver cells. Elsevier Biomedical, New York
Laqueur GL, Mickelsen O, Whiting MG, Kurland LT (1963) Carcinogenic properties of nuts from Cycas circinalis L. indigenous to Guam. JNCI 31:919–951
Squire RA, Brinkhous KM, Peiper SC, Firminger HI, Mann RB, Strandberg JD (1981) Histiocytic sarcoma with a granuloma-like component occurring in a large colony of Sprague-Dawley rats. Am J Pathol 105:21–30
Ward JM, Kulwich BA, Reznik G, Berman JJ (1981) Malignant fibrous histiocytoma. An unusual neoplasm of soft-tissue origin in the rat that is different from the human counterpart. Arch Pathol Lab Med 105:313–316
Wegener K, Hasenohrl K, Wesch H (1983) Recent results of the German Thorotrast study-pathoanatomical changes in animal experiments and comparison to human thorotrastosis. Health Phys 44 [Supply 1]:307–316
Wisse E, Knook DL (1977) Kupffer cells and other liver sinusoidal cells. Elsevier Biomedical, New York
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© 1997 Springer-Verlag Berlin Heidelberg
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Popp, J.A. (1997). Kupffer’s Cell Sarcoma, Liver, Rat. In: Jones, T.C., Popp, J.A., Mohr, U. (eds) Digestive System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60473-7_10
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DOI: https://doi.org/10.1007/978-3-642-60473-7_10
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