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Lessons from Animal Models of Viral Myocarditis

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The Role of Immune Mechanisms in Cardiovascular Disease

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Abstract

Enteroviruses have been identified through in situ hybridization techniques in biopsies from up to 50% of myocarditis and 30% of dilated cardiomyopathy patients [1–3]. The prevalence of viral genomic material in the heart implies an etiological role for enteroviruses in the disease process. A major controversy, however, is whether the virus is the predominant pathogenic element in the disease, or whether the virus acts primarily as a trigger for the induction of immunopathogenic (either autoimmune or virus-immune) myocyte injury. The answer to this question impacts directly on the development of effective therapies for myocarditis and dilated cardiomyopathy.

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Author information

Authors and Affiliations

  1. Department of Pathology, University of Vermont, Burlington, VT, 05405, USA

    S. A. Huber

  2. Department of Physiology and Biophysics, University of Vermont, Burlington, VT, 05405, USA

    B. B. Hamrell

  3. Department of Medicine, University of California, San Diego, CA, USA

    K. U. Knowlton

Authors
  1. S. A. Huber
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  2. B. B. Hamrell
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  3. K. U. Knowlton
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Editor information

Editors and Affiliations

  1. Abteilung für Kardiologie/Pulmologie, Universitätsklinikum Benjamin Franklin der Freien Universität Berlin, Hindenburgdamm 30, 12200, Berlin, Germany

    Heinz-Peter Schultheiss  & Peter Schwimmbeck  & 

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© 1997 Springer-Verlag Berlin Heidelberg

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Huber, S.A., Hamrell, B.B., Knowlton, K.U. (1997). Lessons from Animal Models of Viral Myocarditis. In: Schultheiss, HP., Schwimmbeck, P. (eds) The Role of Immune Mechanisms in Cardiovascular Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60463-8_4

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  • DOI: https://doi.org/10.1007/978-3-642-60463-8_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-61358-9

  • Online ISBN: 978-3-642-60463-8

  • eBook Packages: Springer Book Archive

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