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Molecular Pathogenesis of Myocarditis and Cardiomyopathy: Analysis of Virus-Receptor Interactions and Tyrosine Phosphorylation Events

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The Role of Immune Mechanisms in Cardiovascular Disease

Abstract

Enteroviruses of the human Picornaviridae are common agents of viral myocarditis. Various members of the enterovirus group, e.g. coxsackieviruses and echoviruses, have been associated with viral heart disease. Human enterovirus myocarditis is most often caused by group B coxsackieviruses (CVB) [1–3]. The genetic material of CVB is encoded in a single-stranded RNA molecule of positive polarity and about 7500 nucleotides in length [4, 5]. During replication, the genomic viral plus-strand RNA serves as a template for transcription of minus-strand RNA, an intermediate in the life cycle of enteroviruses, which is transcribed again into large amounts of infectious plus-strand RNA [6].

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Authors and Affiliations

  1. Institute for Pathology, Department of Molecular Pathology, University of Tübingen, 72076, Tübingen, Germany

    H.-C. Selinka, K. Klingel, M. Huber, B. Kramer, U. Kämmerer & R. Kandolf

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  1. H.-C. Selinka
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  2. K. Klingel
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  3. M. Huber
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  4. B. Kramer
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  5. U. Kämmerer
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  6. R. Kandolf
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Editors and Affiliations

  1. Abteilung für Kardiologie/Pulmologie, Universitätsklinikum Benjamin Franklin der Freien Universität Berlin, Hindenburgdamm 30, 12200, Berlin, Germany

    Heinz-Peter Schultheiss  & Peter Schwimmbeck  & 

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© 1997 Springer-Verlag Berlin Heidelberg

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Selinka, HC., Klingel, K., Huber, M., Kramer, B., Kämmerer, U., Kandolf, R. (1997). Molecular Pathogenesis of Myocarditis and Cardiomyopathy: Analysis of Virus-Receptor Interactions and Tyrosine Phosphorylation Events. In: Schultheiss, HP., Schwimmbeck, P. (eds) The Role of Immune Mechanisms in Cardiovascular Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60463-8_2

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  • DOI: https://doi.org/10.1007/978-3-642-60463-8_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-61358-9

  • Online ISBN: 978-3-642-60463-8

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