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Genetic Control of Kidney Morphogenesis

  • Chapter
Drug Toxicity in Embryonic Development I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 124 / 1))

Abstract

The vertebrate excretory unit, the nephron, is functionally conserved and found in all vertebrates, even dating back to the fossil record (Torrey 1965). As might well be expected from this degree of functional conservation across species, the genes thus far implicated in nephrogenesis are also conserved at the molecular level, with sequence conservation extending even to genes expressed in the primitive excretory organ of the fruit fly, Drosophila melanogaster. The purpose of this chapter is to review recent advances in the molecular genetics of kidney development and to correlate this information with a rich body of information on nephrogenesis derived from experimental embryology and developmental biology. A definitive monograph on the cell biology of kidney organogenesis has been published (Saxén 1987), and two recent mini-reviews and a “kidney gene-expression database” are also available (Clapp and Abrahamson 1993; Bard et al. 1994, 1996).

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  1. R. Maas
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  1. Reproductive Toxicology Division (MD-71), National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, 27711, Research Triangle Park, NC, USA

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  2. Miami Valley Laboratories, The Procter and Gamble Company, P.O. Box 538707, 45253, Cincinnati, OH, USA

    George P. Daston Ph.D.

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Maas, R., Rauchman, M. (1997). Genetic Control of Kidney Morphogenesis. In: Kavlock, R.J., Daston, G.P. (eds) Drug Toxicity in Embryonic Development I. Handbook of Experimental Pharmacology, vol 124 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60445-4_6

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