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Prostaglandin Metabolism

  • Chapter
Drug Toxicity in Embryonic Development I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 124 / 1))

Abstract

Prostaglandins are 20-carbon polyunsaturated fatty acids containing a cyclopentane ring and two side chains, and they are distinguished by their very potent biological activities. The basic skeleton, prostanoic acid, and a typical naturally occurring prostaglandin, prostaglandin E2 (PGE2), are depicted in Fig. 1. Each prostaglandin is designated by a letter of the alphabet, A–J, according to the composition of its cyclopentane ring, and by a numerical subscript indicating the number of double bonds in the alkyl side chains. In prostaglandins of the F series, subscripts α or β indicate the orientation of the hydroxyl group at C-9 in the ring.

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Authors
  1. M. P. Goto
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  2. A. S. Goldman
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Editors and Affiliations

  1. Reproductive Toxicology Division (MD-71), National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, 27711, Research Triangle Park, NC, USA

    Robert J. Kavlock Ph.D. (Director) (Director)

  2. Miami Valley Laboratories, The Procter and Gamble Company, P.O. Box 538707, 45253, Cincinnati, OH, USA

    George P. Daston Ph.D.

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Goto, M.P., Goldman, A.S. (1997). Prostaglandin Metabolism. In: Kavlock, R.J., Daston, G.P. (eds) Drug Toxicity in Embryonic Development I. Handbook of Experimental Pharmacology, vol 124 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60445-4_16

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  • Print ISBN: 978-3-642-64408-5

  • Online ISBN: 978-3-642-60445-4

  • eBook Packages: Springer Book Archive

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