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Wirkmechanismen der Photo- und Photochemotherapie

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Handbuch der dermatologischen Phototherapie und Photodiagnostik

Zusammenfassung

Sowohl die UVB-Phototherapie als auch die systemische Photochemotherapie mit oraler Gabe von Psoralenen und nachfolgender UVA-Bestrahlung (Psoralen + UVA = PUVA) eignen sich zur effektiven Behandlung der Psoriasis, d. h. einer entzündlichen Hauterkrankung, für die eine Hyperproliferation epidermaler Keratinozyten charakteristisch ist [33, 39, 40]. Daher wurde zunächst davon ausgegangen, daß die therapeutische Effektivitäst beider Verfahren auf ihrer Fähigkeit beruht, antiproliferativ zu wirken. Für beide Therapieformen kam es jedoch in der Folgezeit zu einer umfassenden Erweiterung des Indikationsspektrums, das heute Hauterkrankungen umfaßt, bei denen hyperproliferative Prozesse von keiner oder untergeordneter, immunologische Veränderungen jedoch von herausragender Bedeutung sind [53]. Es wurde daher bereits in den siebziger Jahren spekuliert, daß die therapeutische Effektivität der Photo- und Photochemotherapie wesentlich auf der Fähigkeit ultravioletter Strahlung beruht, das Immunsystem Haut zu beeinflussen [21]. Eine Vielzahl der mitterweile nachgewiesenen immunmodulatorischen Effekte lassen sich zugleich bei UVB,- UVA- und PUVA-Therapie beobachten, obwohl diese Therapieprinzipien auf unterschiedlichen photobiologischen Mechanismen beruhen. Das vorliegende Kapitel orientiert sich daher nicht an einzelnen Therapieformen; vielmehr werden allgemein gültige, mit einer Photo- oder Photochemotherapie einhergehende Wirkprinzipien vorgestellt.

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Authors
  1. Jean Krutmann
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Editors and Affiliations

  1. Hautklinik, Heinrich-Heine-Universität, Moorenstraße 5, D-40225, Düsseldorf, Germany

    Jean Krutmann

  2. Universitätsklinik für Dermatologie, Allgemeines Krankenhaus der Stadt Wien, Währinger Gürtel 18-20, A-1090, Wien, Germany

    Herbert Hönigsmann

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© 1997 Springer-Verlag Berlin Heidelberg

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Krutmann, J. (1997). Wirkmechanismen der Photo- und Photochemotherapie. In: Krutmann, J., Hönigsmann, H. (eds) Handbuch der dermatologischen Phototherapie und Photodiagnostik. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60425-6_2

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  • DOI: https://doi.org/10.1007/978-3-642-60425-6_2

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