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Photodynamische Therapie in der Dermatologie

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Handbuch der dermatologischen Phototherapie und Photodiagnostik

Zusammenfassung

Der photodynamische Effekt wurde bereits vor nahezu 100 Jahren im Wintersemester 1897/98 durch den Medizinstudenten Oscar Raab im Rahmen seiner Dissertation am Pharmakologischen Institut der Ludwig-Maximilians-Universität in München entdeckt [115] und auch bei Patienten therapeutisch eingesetzt [67, 146]. Für onkologische Indikationen (Blase, Ösophagus, Lunge) ist die photodynamische Therapie (PDT) bereits in Japan, Kanada, USA und den Niederlanden zugelassen, nicht jedoch für dermatologische Indikationen. Dabei ist gerade in den vergangenen Jahren die Wirksamkeit bei der Behandlung von oberflächlichen Hauttumoren oder der Psoriasis ausführlich beschrieben und dokumentiert worden [24, 35, 37, 42, 76, 92, 109, 133, 139, 161].

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Literatur

  1. Abels C, Heil P, Dellian M, Kuhnle GEH, Baumgartner R, Goetz AE (1994) In vivo kinetics and spectra of 5-aminolevulinic acid-induced fluorescence in an amelanotic melanoma of the hamster. Br J Cancer 70:826–833.

    Article  PubMed  CAS  Google Scholar 

  2. Abels C, Dellian M, Szeimies RM, Steinbach P, Richert C, Goetz AE (1995) Swift PDT — A new therapeutic regimen. J Invest Dermatol 105:511.

    Google Scholar 

  3. Abels C, Dellian M, Szeimies RM, Steinbach P, Richert C, Goetz AE (1996) Targeting of the tumor microcirculation with a new photosensitizer. In: Ehrenberg B, Jori G, Moan J (eds) Photochemotherapy: Photodynamic Therapy and Other Modalities. Proc SPIE 2625, pp 164–169

    Google Scholar 

  4. Abramson AL, Alvi A, Mullooly VM (1993) Clinical exacerbation of systemic lupus erythematosus after photodynamic therapy of laryngotracheal papillomatosis. Lasers Surg Med 13:677–679.

    Article  PubMed  CAS  Google Scholar 

  5. Ammann R, Hunziker T (1995) Photodynamic therapy for mycosis fungoides after topical photosensitization with 5-aminolevulinic acid. J Am Acad Dermatol 33:541.

    Article  PubMed  CAS  Google Scholar 

  6. Anderson RR, Parrish JA (1981) The optics of human skin. J Invest Dermatol 77:13–19.

    Article  PubMed  CAS  Google Scholar 

  7. Aramendia PF, Redmond RW, Nonell S, Schuster W, Braslavsky SE, Schaffner K, Vogel E (1986) The photophysical properties of porphycenes: potential photodynamic therapy agents. Photochem Photobiol 44:555–559.

    Article  PubMed  CAS  Google Scholar 

  8. Auler H, Banzer G (1942) Untersuchungen über die Rolle der Porphyrine bei geschwulstkranken Menschen und Tieren. Z Krebsforsch 53:65–68.

    Article  CAS  Google Scholar 

  9. Babich D, Whitaker J, Conti C, Blaird-Wagner D, Stoll HL, Dozier S, Oseroff AR (1996) Treatment of all stages of cutaneous T-cell lymphomas with fractionated photodynamic therapy using topical δ-aminolevulinic acid. J Invest Dermatol 106:840.

    Google Scholar 

  10. Bandieramonte G, Marchesini R, Melloni E et al. (1984) Laser phototherapy following HpD administration in superficial neoplastic lesions. Tumori 70:327–334.

    PubMed  CAS  Google Scholar 

  11. Batlle AM del C (1993) Porphyrins, porphyrias, cancer and photodynamic therapy — a model for carcinogenesis. J Photochem Photobiol B: Biol 20:5–22.

    Article  CAS  Google Scholar 

  12. Bedwell J, MacRobert AJ, Phillips D, Bown SC (1992) Fluorescence distribution and photodynamic effect of ALA-induced PpIX in the DMH rat colonic tumour model. Br J Cancer, 65:818–824.

    Article  PubMed  CAS  Google Scholar 

  13. Bellnier DA (1991) Potentiation of photodynamic therapy in mice with recombinant human tumor necrosis factor-alpha. J Photochem Photobiol B: [Biol] 8:203–210.

    Article  CAS  Google Scholar 

  14. Bellnier DA, Ho YK, Pandey RK, Missert JR, Dougherty TJ (1989) Distribution and elimination of Photofrin II in mice. Photochem Photobiol 50:221–228.

    Article  PubMed  CAS  Google Scholar 

  15. Berg H, Bauer E, Gollmick FA, Diezel W, Böhm F, Meffert H, Sönnichsen N (1985) Photodynamic hematoporphyrin therapy of psoriasis. In: Jori G, Perria C (eds) Photodynamic therapy of tumors and other diseases. Progetto, Padova, pp 337–343.

    Google Scholar 

  16. Berglund L, Angelin B, Blomstrand R, Drummond G, Kappas A (1988) Sn-protopor-phyrin lowers serum bilirubin levels, decreases biliary bilirubin output, enhances biliary heme excretion and potently inhibits hepatic heme oxygenase activity in normal human subjects. Hepatology 8:625–631.

    Article  PubMed  CAS  Google Scholar 

  17. Berlin NI, Neuberger A, Scott JJ (1956) The metabolism of δ-aminolevulinic acid. 1. Normal pathways, studied with the aid of 15N. Biochem J 64:80–90.

    PubMed  CAS  Google Scholar 

  18. Berns MW, Dahlman A, Johnson FM et al. (1982) In vitro cellular effects of hematoporphyrin derivative. Cancer Res 42:2325–2329.

    PubMed  CAS  Google Scholar 

  19. Berns MW, Rettenmeier M, McCullough J et al. (1984) Response of psoriasis to red laser light (630 nm) following systemic injection of hematoporphyrin derivative. Lasers Surg Med 4:73–77.

    Article  PubMed  CAS  Google Scholar 

  20. Biel MA (1995) Photodynamic therapy of head and neck cancers. Semin Surg Oncol 11:355–359.

    Article  PubMed  CAS  Google Scholar 

  21. Bockstahler LE, Coohill TP, Hellman KB, Lytle CD, Roberts JE (1979) Photodynamic therapy for herpes simplex: a critical review. Pharmacol Ther 4:473–499.

    Article  PubMed  CAS  Google Scholar 

  22. Boehncke WH, König K, Kaufmann R, Scheffold W, Prümmer O, Sterry W (1994) Photodynamic therapy in psoriasis: suppression of cytokine production in vitro and recording of fluorescence modification during treatment in vivo. Arch Dermatol Res 286:300–303.

    Article  PubMed  CAS  Google Scholar 

  23. Boehncke WH, König K, Rück A, Kaufmann R, Sterry W (1994) In vitro and in vivo effects of photodynamic therapy in cutaneous T cell lymphoma. Acta Derm Venereol (Stockh) 74:201–205.

    CAS  Google Scholar 

  24. Boehncke WH, Sterry W, Kaufmann R (1994) Treatment of psoriasis by topical photodynamic therapy with polychromatic light. Lancet 343:801.

    Article  PubMed  CAS  Google Scholar 

  25. Bretschko E, Szeimies RM, Landthaler M, Lee G (1996) Topical 5-aminolevulinic acid for photodynamic therapy of basal cell carcinoma. Evaluation of stratum corneum permeability in vitro. J Contr Release 42:203–208.

    CAS  Google Scholar 

  26. Buchanan RB, Carruth JAS, McKenzie AL, Williams SR (1989) Photodynamic therapy in the treatment of malignant tumours of the skin and head and neck. Eur J Surg Oncol 15:400–406.

    PubMed  CAS  Google Scholar 

  27. Cairnduff F, Stringer MR, Hudson EJ, Ash DV, Brown SB (1994) Superficial photodynamic therapy with topical 5-aminolevulinic acid for superficial primary and secondary skin cancer. Br J Cancer 69:605–608.

    Article  PubMed  CAS  Google Scholar 

  28. Calzavara F, Tornio L (1991) Photodynamic therapy: clinical experience at the department of radiotherapy at Padova general hospital. J Photochem Photobiol B: Biol 11:91–95.

    Article  CAS  Google Scholar 

  29. Calzavara-Pinton PG (1995) Repetitive photodynamic therapy with topical δ-aminolevulinic acid as an appropriate approach to the routine treatment of superficial non-melanoma skin tumours. J Photochem Photobiol B: [Biol] 29:53–57.

    Article  CAS  Google Scholar 

  30. Castellani A, Page GP, Concioli M (1963) Photodynamic effect of hematoporphyrin on blood microcirculation. J Pathol Bacteriol 86:99–102.

    Article  PubMed  CAS  Google Scholar 

  31. Dellian M, Walenta S, Gamarra F, Kuhnle GE, Mueller-Klieser W, Goetz AE (1994) High-energy shock waves enhance hyperthermic response of tumors: effects on blood flow, energy metabolism, and tumor growth. J Natl Cancer Inst 86:287–293.

    Article  PubMed  CAS  Google Scholar 

  32. Dellian M, Abels C, Kuhnle GE, Goetz AE (1995) Effects of photodynamic therapy on leucocyte-endothelium interaction: differences between normal and tumour tissue. Br J Cancer 72:1125–1130.

    Article  PubMed  CAS  Google Scholar 

  33. Divaris DXC, Kennedy JC, Pottier RH (1990) Phototoxic damage to sebaceous glands and hair follicles of mice following systemic administration of 5-aminolevulinic acid correlates with localized protoporphyrin IX fluorescence. Am J Pathol 136:891–897.

    PubMed  CAS  Google Scholar 

  34. Dougherty TJ (1985) Photodynamic therapy. Adv Exp Biol 193:313–328.

    CAS  Google Scholar 

  35. Dougherty TJ (1981) Photoradiation therapy for cutaneous and subcutaneous malignancies. J Invest Dermatol 77:122–124.

    Article  PubMed  CAS  Google Scholar 

  36. Dougherty TJ, Grindey GB, Fiel R, Weishaupt KR, Boyle DG (1975) Photoradiation therapy. II. Cure of animal tumors with hematoporphyrin and light. J Natl Cancer Inst 55:115–121.

    CAS  Google Scholar 

  37. Dougherty TJ, Kaufman JE, Goldfarb A, Weishaupt KR, Boyle D, Mittleman A (1978) Photoradiation therapy for the treatment of malignant tumors. Cancer Res 38:2628–2635.

    PubMed  CAS  Google Scholar 

  38. Elmets CA, Bowen KD (1986) Immunological suppression in mice treated with hematoporphyrin derivative photoradiation. Cancer Res 46:1608–1611.

    PubMed  CAS  Google Scholar 

  39. Emtestam L, Berglund L, Angelin B, Drummond GS, Kappas A (1989) Tin-protopor-phyrin and long wavelength ultraviolet light in treatment of psoriasis. Lancet I:1231–1233

    Article  Google Scholar 

  40. Evans S, Matthews W, Perry R, Fraker D, Norton J, Pass HI (1990) Effect of photodynamic therapy on tumor necrosis factor production by murine macrophages. J Natl Cancer Inst 82:34–39.

    Article  PubMed  CAS  Google Scholar 

  41. Feyh J, Gutmann R, Leunig A (1993) Die photodynamische Lasertherapie im Bereich der Hals-, Nasen-, Ohrenheilkunde. Laryngol Rhinol Otol 72:273–278.

    Article  CAS  Google Scholar 

  42. Fijan S, Hönigsmann H, Ortel B (1995) Photodynamic therapy of epithelial skin tumours using delta-aminolevulinic acid and desferrioxamine. Br J Dermatol 133:282–288.

    Article  PubMed  CAS  Google Scholar 

  43. Fijan S, Hönigsmann H, Tanew A (1996) Photodynamic therapy of keratoacanthoma using topical delta-aminolevulinic acid. J Invest Dermatol 106:945 (abstr).

    Google Scholar 

  44. Fingar VH, Wieman TJ, Doak KW (1990) Role of thromboxane and prostacyclin release on photodynamic therapy-induced tumor destruction. Cancer Res 50:2599–2603.

    PubMed  CAS  Google Scholar 

  45. Fingar VH, Wieman TJ, Wiehle SA, Cerrito PB (1992) The role of microvascular damage in photodynamic therapy: the effect of treatment on vessel constriction, permeability, and leukocyte adhesion. Cancer Res 52:4914–4921.

    PubMed  CAS  Google Scholar 

  46. Forbes IJ, Cowled PA, Leong ASY, Ward AD, Black RB, Blake AJ, Jacka FJ (1980) Phototherapy of human tumours using hematoporphyrin derivative. Med J Aust 2:489–493.

    PubMed  CAS  Google Scholar 

  47. Foster TH, Primavera MC, Marder VJ, Hilf R, Sporn LA (1991) Photosensitized release of von Willebrand factor from cultured human endothelial cells. Cancer Res 51:3261–3266.

    PubMed  CAS  Google Scholar 

  48. Frank RGJ, Bos JD, Vandermeulen FW, Sterenborg HJCM (1996) Photodynamic therapy for condylomata acuminata with local application of 5-aminolevulinic acid. Genitourin Med 72:70–71.

    PubMed  CAS  Google Scholar 

  49. Friedrich EG (1973) Relief for herpes vulvitis. Obstet Gynecol 41:74–77.

    PubMed  Google Scholar 

  50. Frisch C, Vocks E, Herzog M, Vogt HJ, Borelli S (1996) Persistierende Photosensibilisierung - eine Verlaufsbeobachtung nach i.v.-PDT. Akt Dermatol 22:98–103

    Google Scholar 

  51. Goldin A, Schabel FM (1981) Clinical concepts derived from animal chemotherapy studies. Cancer Treat Rep 65 [Suppl] 3:11–19.

    PubMed  CAS  Google Scholar 

  52. Gomer CJ, Ferrario A, Rucker N, Wong S, Lee AS (1991) Glucose regulated protein induction and cellular resistance to oxidative stress mediated by porphyrin photo-sensitization. Cancer Res 51:6574–6579.

    PubMed  CAS  Google Scholar 

  53. Gross DJ, Waner M, Schosser RH, Dinehart SM (1990) Squamous cell carcinoma of the lower lip involving a large cutaneous surface. Photodynamic therapy as an alternative therapy. Arch Dermatol 126:1148–1150.

    CAS  Google Scholar 

  54. Guardiano M, Biolo R, Jori G, Schaffner K (1989) Tetra-n-propylporphycene as a tumour localizer: pharmacokinetic and phototherapeutic studies in mice. Cancer Lett 44:1–6.

    Article  PubMed  CAS  Google Scholar 

  55. Gutmann R, Leunig M, Feyh J, Goetz AE, Messmer K, Kastenbauer E, Jain RK (1992) Interstitial hypertension in head and neck tumors in patients: correlation with tumor size. Cancer Res 52:1993–1995.

    PubMed  CAS  Google Scholar 

  56. Haina D, Landthaler M, Braun-Falco O, Waidelich W (1987) Comparison of the maximum coagulation depth in human skin for different types of medical lasers. Lasers Surg Med 7:355–362.

    Article  PubMed  CAS  Google Scholar 

  57. Hamblin MR, Newman EL (1994) On the mechanism of the tumour-localising effect in photodynamic therapy. J Photochem Photobiol B: Biol 23:3–8.

    Article  CAS  Google Scholar 

  58. Hanania J, Malik Z (1992) The effect of EDTA and serum on endogenous porphyrin accumulation and photodynamic sensitization of human K562 leukemic cells. Cancer Lett 65:127–131.

    Article  PubMed  CAS  Google Scholar 

  59. He D, Sassa S, Lim HW (1993) Effect of UVA and blue light on porphyrin biosynthesis in epidermal cells. Photochem Photobiol 57:825–829.

    Article  PubMed  CAS  Google Scholar 

  60. Hebeda KM, Huizing MT, Brouwer PA et al. (1995) Photodynamic therapy in AIDS-related cutaneous Kaposi’s sarcoma. J Acquir Immune Defic Syndr Hum Retrovirol 10:61–70.

    PubMed  CAS  Google Scholar 

  61. Henderson BW, Donovan JM (1989) Release of prostaglandin E2 from cells by photodynamic treatment in vitro. Cancer Res 49:6896–6900.

    PubMed  CAS  Google Scholar 

  62. Hendrich C, Hüttmann G, Diddens H, Seara J, Siebert WE (1996) Experimentelle Grundlagen einer photodynamischen Lasertherapie für die chronische Polyarthritis. Orthopäde 25:30–36.

    PubMed  CAS  Google Scholar 

  63. Hintschich C, Feyh J, Beyer-Machule C, Riedel K, Ludwig K (1993) Photodynamic laser therapy of basal-cell carcinoma of the lid. Ger J Ophthalmol 2:212–217.

    PubMed  CAS  Google Scholar 

  64. Hoerauf H, Hüttmann G, Diddens H, Thiele B, Laqua H (1994) Die photodynamische Therapie (PDT) des Lidbasalioms nach topischer Applikation von δ-Aminolä-vulinsäure (ALA). Ophthalmologe 91:824–829.

    PubMed  CAS  Google Scholar 

  65. Hohenleutner U, Szeimies RM, Landthaler M (1993) Photodynamische Therapie zur Behandlung oberflächlicher Basaliome. In: Braun-Falco O, Plewig G, Meurer M (Hrsg) Fortschritte der praktischen Dermatologie und Venerologie, Bd 13. Springer, Berlin Heidelberg New York Tokyo, S 472–474.

    Google Scholar 

  66. Hürlimann AF, Panizzon RA, Burg G (1994) Topical photodynamic treatment of skin tumors and dermatoses. Dermatology 3:327 (abstr).

    Google Scholar 

  67. Jesionek A, Tappeiner H von (1905) Zur Behandlung der Hautcarcinome mit fluo-rescierenden Stoffen. Dtsch Arch Klin Med 85:223–239.

    Google Scholar 

  68. Jolles CJ, Ott MJ, Straight RC, Lynch DH (1988) Systemic immunosuppression induced by peritoneal photodynamic therapy. Am J Obstet Gynecol 158: 1446–1453.

    PubMed  CAS  Google Scholar 

  69. Jones CM, Mang T, Cooper M, Wilson DB, Stoll HL (1992) Photodynamic therapy in the treatment of Bowen’s disease. J Am Acad Dermatol 27:979–982.

    Article  PubMed  CAS  Google Scholar 

  70. Jones LR, Grossweiner LI (1994) Singlet oxygen generation by Photofrin in homogeneous and light-scattering media. J Photochem Photobiol B: [Biol] 26: 249–256.

    Article  CAS  Google Scholar 

  71. Kamide R, Gigli I, Lim HW (1984) Participation of mast cells and complement in the immediate phase of hematoporphyrin-induced phototoxicity. J Invest Dermatol 82:485–490.

    Article  PubMed  CAS  Google Scholar 

  72. Kappas A, Sassa S, Galbraith RA, Nordmann Y (1989) The porphyrias. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The metabolic basis of inherdisease, 6th edn. McGraw-Hill, New York, pp 1305–1366.

    Google Scholar 

  73. Karrer S, Szeimies RM, Hohenleutner U, Heine A, Landthaler M (1995) Unilateral localized basaliomatosis: treatment with topical photodynamic therapy after application of 5-aminolevulinic acid. Dermatology 190:218–222.

    Article  PubMed  CAS  Google Scholar 

  74. Karrer S, Abels C, Szeimies RM, Bäumler W, Hohenleutner U, Goetz AE, Landthaler M (1996) Topical application of a novel porphycene dye for photodynamic therapy - penetration studies in human perilesional skin and basal cell carcinoma. In: Ehrenberg B, Jori G, Moan J (eds) Photochemotherapy: photodynamic therapy and other modalities, Proc SPIE 2625, pp 278–280.

    Google Scholar 

  75. Kennedy JC, Pottier RH (1992) Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy. J Photochem Photobiol, B: Biol, 14:275–292.

    Article  CAS  Google Scholar 

  76. Kennedy JC, Pottier RH, Pross DC (1990) Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience. J Photochem Photobiol B: [Biol] 6:143–148.

    Article  CAS  Google Scholar 

  77. Kerdel FA, Soter NA, Lim HW (1987) In vivo mediator release and degranulation of mast cells in hematoporphyrin derivative-induced phototoxicity in mice. J Invest Dermatol 88:277–280.

    Article  PubMed  CAS  Google Scholar 

  78. Kessel D (1986) Sites of photosensitization by derivatives of hematoporphyrin. Photochem Photobiol 44:489–493.

    Article  PubMed  CAS  Google Scholar 

  79. Kick G, Messer G, Goetz A, Plewig G, Kind P (1995) Photodynamic therapy induces expression of interleukin 6 by activation of AP-1 but not NF-kappa B DNA binding. Cancer Res 55:2373–2379.

    PubMed  CAS  Google Scholar 

  80. König K, Schneckenburger H, Rück A, Steiner R (1993) In vivo photoproduct formation during PDT with ALA-induced endogenous porphyrins. J Photochem Photobiol B: [Biol] 18:287–290.

    Article  Google Scholar 

  81. Korell M, Untch M, Abels C et al. (1995) Einsatz der photodynamischen Lasertherapie in der Gynäkologie. Gynäkol Geburtshilfl Rundsch 35:90–97.

    Article  CAS  Google Scholar 

  82. Landthaler M (1992) Premalignant and malignant skin lesions. In: Achauer BM, Vander Kam VM, Berns MW (eds) Lasers in plastic surgery and dermatology. Thieme, New York, pp 34–44.

    Google Scholar 

  83. Landthaler M, Rück A, Szeimies RM (1993) Photodynamische Therapie von Tumoren der Haut. Hautarzt 44:69–74.

    PubMed  CAS  Google Scholar 

  84. Lang S, Baumgartner R, Struck R, Leunig A, Gutmann R, Feyh J (1995) Photodynamische Diagnostik und Therapie von Neoplasien der Gesichtshaut nach topischer Applikation von 5-Aminolävulinsäure. Laryngol Rhinol Otol 74:85–89.

    Article  CAS  Google Scholar 

  85. Langer S, Abels C, Szeimies RM, Goetz AE (1995) Photodynamic diagnosis and therapy of tumors with topically applied 5-aminolevulinic acid. J Invest Dermatol 105:511 (abstr).

    Google Scholar 

  86. Leunig M, Richert C, Gamarra F, Lumper W, Vogel E, Jocham D, Goetz AE (1993) Tumour localisation kinetics of photofrin and three synthetic porphyrinoids in an amelanotic melanoma of the hamster. Br J Cancer 68:225–234.

    Article  PubMed  CAS  Google Scholar 

  87. Leunig A, Staub F, Peters J, Leiderer R, Feyh J, Goetz AE (1994) Die Schädigung von Tumorzellen durch die photodynamische Therapie. Laryngol Rhinol Otol 73:102–107.

    Article  CAS  Google Scholar 

  88. Leunig M, Goetz AE, Gamarra F, Zetterer G, Messmer K, Jain RK (1994) Photodynamic therapy-induced alterations in interstitial fluid pressure, volume and water content of an amelanotic melanoma in the hamster. Br J Cancer 69: 101–103.

    Article  PubMed  CAS  Google Scholar 

  89. Levy JG, Jones CA, Pilson LA (1994) The preclinical and clinical development and potential application of benzoporphyrin derivative. International Photodynamics 1:3–5.

    Google Scholar 

  90. Lipson RL, Baldes EJ (1960) The photodynamic properties of a particular haematoporphyrin derivative. Arch Dermatol 82:508–516

    PubMed  CAS  Google Scholar 

  91. Lipson RL, Gray MJ, Baldes EJ (1966) Haematoporphyrin derivative for detection and management of cancer. Proc IX Internat Cancer Congr 393

    Google Scholar 

  92. Lui H, Anderson RR (1992) Photodynamic therapy in dermatology. Arch Dermatol 128:1631–1636.

    Article  PubMed  CAS  Google Scholar 

  93. Lui H, Kollias N, Wimberly J, Anderson RR (1992) Photosensitizing potential of benzoporphyrin derivative-monoacid ring A (BPD-MA) in patients undergoing photodynamic therapy. Photochem Photobiol 55:[Suppl] 30S (abstr).

    Google Scholar 

  94. Lui H, Salasche S, Kollias N, Wimberly J, Flotte T, McLean D, Anderson RR (1995) Photodynamic therapy of nonmelanoma skin cancer with topical aminolevulinic acid: a clinical and histologic study. Arch Dermatol 131:737–738.

    Article  PubMed  CAS  Google Scholar 

  95. Lynch DH, Haddad S, King VJ, Ott MJ, Straight RC, Jolles CJ (1989) Systemic immunosuppression induced by photodynamic therapy (PDT) is adoptively transferred by macrophages. Photochem Photobiol 49:453–458.

    Article  PubMed  CAS  Google Scholar 

  96. Martin A, Tope WD, Grevelink JM et al. (1995) Lack of selectivity of protoporphyrin IX fluorescence for basal cell carcinoma after topical application of 5-aminolevuli-nic acid: implications for photodynamic treatment. Arch Dermatol Res 287:665–674.

    Article  PubMed  CAS  Google Scholar 

  97. McCaughan JS Jr, Guy JT, Hicks W, Laufman L, Nims TA, Walker J (1989) Photodynamic therapy for cutaneous and subcutaneous malignant neoplasms. Arch Surg 124:211–216.

    PubMed  Google Scholar 

  98. McCullough JL, Weinstein GD, Lemus LL, Rampone W, Jenkins JJ (1983) Development of a topical hematoporphyrin derivative formulation: Characterization of photosensitizing effects in vivo. J Invest Dermatol 81:528–532.

    Article  PubMed  CAS  Google Scholar 

  99. Meffert H, Pres H, Diezei W, Sönnichsen N (1989) Antipsoriatische und phototoxische Wirksamkeit von Hämatoporphyrin-Derivat nach topischer Applikation und Bestrahlung mit sichtbarem Licht. Dermatol Monatsschr 175:28–34.

    PubMed  CAS  Google Scholar 

  100. Milanesi C, Zhou C, Biolo R, Jori G (1990) Zn(II)-phthalocyanine as a photodynamic agent for tumours. II. Studies on the mechanism of photosensitised tumour necrosis. Br J Cancer 61:846–850.

    CAS  Google Scholar 

  101. Monfrecola G, Dánna F, Delfino M (1987) Topical hematoporphyrin plus UVA for treatment of alopecia areata. Photodermatol Photoimmunol Photomed 4: 305–306.

    CAS  Google Scholar 

  102. Nelson JS (1993) Photodynamic therapy of port wine stain: preliminary clinical studies. In: Shapshay SM, Anderson RR, White JV, White RA, Bass LR (eds) Lasers in otolaryngology, dermatology, and tissue welding. Proc SPIE 1876, pp 142–146.

    Google Scholar 

  103. North J, Coombs R, Levy JG (1994) Photodynamic inactivation of free and cell-associated HIV-1 using the photosensitizer, benzoporphyrin derivative. J Acquir Immune Defic Syndr 7:891–898.

    PubMed  CAS  Google Scholar 

  104. Nseyo UO, Whalen RK, Duncan MR, Berman B, Lundahl SL (1990) Urinary cytokines following photodynamic therapy for bladder cancer. A preliminary report. Urology 36:167–171.

    CAS  Google Scholar 

  105. Nugent LJ, Jain RK (1984) Extravascular diffusion in normal and neoplastic tissues. Cancer Res 44: 238–244.

    PubMed  CAS  Google Scholar 

  106. Obochi MO, Canaan AJ, Jain AK, Richter AM, Levy JG (1995) Targeting activated lymphocytes with photodynamic therapy: susceptibility of mitogen-stimulated splenic lymphocytes to benzoporphyrin derivative (BPD) photosensitization. Photochem Photobiol 62:169–175.

    Article  PubMed  CAS  Google Scholar 

  107. Ortel B, Tanew A, Hönigsmann H (1993) Lethal photosensitization by endogenous porphyrins of PAM cells - modification by desferrioxamine. J Photochem Photobiol B: Biol 17:273–278.

    Article  CAS  Google Scholar 

  108. Oseroff AR (1993) Photodynamic therapy. In: Lim HW, Soter NA (eds) Clinical photomedicine. Dekker, New York, pp 387–402.

    Google Scholar 

  109. Pass HI (1993) Photodynamic therapy in oncology: mechanisms and clinical use. J Natl Cancer Inst 85:443–56.

    Article  PubMed  CAS  Google Scholar 

  110. Peng Q, Warloe T, Moan J (1995) Topically-applied ALA-based PDT for nodulo-ulcerative basal cell carcinoma. IPA news 7:2.

    Google Scholar 

  111. Penning LC, Tijssen K, Van Steveninck J, Dubbelman TM (1994) Hematoporphyrin derivative-induced photodynamic inhibition of Na+/K(+)-ATPase in L929 fibroblasts, Chinese hamster ovary cells and T24 human bladder transitional carcinoma cells. Photochem Photobiol 59:336–341.

    Article  PubMed  CAS  Google Scholar 

  112. Pennington DG, Waner M, Knox A (1988) Photodynamic therapy for multiple skin cancers. Plast Reconstr Surg 82:1067–1071.

    Article  PubMed  CAS  Google Scholar 

  113. Pres H, Meffert H, Sönnichsen N (1989) Photodynamische Therapie der Psoriasis palmaris et plantaris mit topisch appliziertem Hämatoporphyrin-Derivat und sichtbarem Licht. Dermatol Monatsschr 175:745–750.

    PubMed  CAS  Google Scholar 

  114. Qin B, Selman SH, Payne KM, Keck RW, Metzger DW (1993) Enhanced skin allograft survival after photodynamic therapy. Association with lymphocyte inactivation and macrophage stimulation. Transplantation 56:1481–1486.

    CAS  Google Scholar 

  115. Raab O (1900) Über die Wirkung fluorescierender Stoffe auf Infusoria. Z Biol 39:524.

    CAS  Google Scholar 

  116. Rebeiz N, Rebeiz CC, Arkins S, Kelley KW, Rebeiz CA (1992) Photodestruction of tumor cells by induction of endogenous accumulation of protoporphyrin IX: enhancement by 1,10-phenanthroline. Photochem Photobiol 55:431–435.

    Article  PubMed  CAS  Google Scholar 

  117. Rebeiz N, Arkins S, Rebeiz CA, Simon J, Zachary JF, Kelley KW (1996) Induction of tumor necrosis by δ-aminolevulinic acid and 1,10-phenantroline photodynamic therapy. Cancer Res 56:339–344.

    PubMed  CAS  Google Scholar 

  118. Richert C, Wessels JM, Müller M, Kisters M, Benninghaus T, Goetz AE (1994) Photodynamic antitumor agents: β-methoxyethyl groups give access to functionalized porphycenes and enhance cellular uptake and activity. J Med Chem 37:2797–2807.

    Article  PubMed  CAS  Google Scholar 

  119. Richter AM, Jain AK, Canaan AJ, Waterfield E, Sternberg ED, Levy JG (1992) Photosensitizing efficiency of two regioisomers of the benzoporphyrin derivative monoacid ring A. Biochem Pharmacol 43:2349–2358.

    Article  PubMed  CAS  Google Scholar 

  120. Rittenhouse-Diakun K, Van Leengoed H, Morgan J, Hryhorenko E, Paszkiewicz G, Whitaker JE, Oseroff AR (1995) The role of transferrin receptor (CD71) in photodynamic therapy of activated and malignant lymphocytes using the heme precursor delta-aminolevulinic acid (ALA). Photochem Photobiol 61:523–528.

    Article  PubMed  CAS  Google Scholar 

  121. Robinson PJ, Carruth JAS, Fairris GM (1988) Photodynamic therapy: a better treatment for widespread Bowen’s disease. Br J Dermatol 119:59–61.

    Article  PubMed  CAS  Google Scholar 

  122. Rosenblum LA, Hoskwith B, Kramer SD (1937) Photodynamic action of methylene blue on poliomyelitis virus. Proc Soc Exp Biol Med 37:166–169.

    Google Scholar 

  123. Rünger TM (1995) Genotoxizität, Mutagenität und Karzinogenität von UVA und UVB. Z Hautkr 70:877–881.

    Google Scholar 

  124. Sacchini V, Melloni E, Marchesini R, Fabrizio T, Cascinelli N, Santoro 0, Zunino F, Andreola S, Bandieramonte G (1987) Topical administration of tetrasodium-meso-tetraphenyl-porphinesulfonate (TPPS) and red light irradiation for the treatment of superficial neoplastic lesions. Tumori 73:19–23.

    PubMed  CAS  Google Scholar 

  125. Schaffner K, Vogel E, Jori G (1994) Porphycenes as photodynamic therapy agents. In: Jung EG, Holick MF (eds) Biologic effects of light 1993. Walter de Gruyter, Berlin, pp 312–321.

    Google Scholar 

  126. Schlag P, Hünerbein M, Stern J, Gahlen J, Graschew G (1992) Photodynamische Therapie — Alternative bei lokal rezidiviertem Mamma-Karzinom. Dtsch Ärztebl 89:680–687.

    Google Scholar 

  127. Schmidt S, Wagner U, Oehr P, Krebs D (1992) Klinischer Einsatz der photodynamischen Therapie bei gynäkologischen Tumorpatienten - Antikörper-vermittelte photodynamische Lasertherapie als neues onkologisches Behandlungsverfahren. Zen-tralbl Gynäkol 114:307–311.

    CAS  Google Scholar 

  128. Schuh M, Nseyo UO, Potter WR, Dao TL, Dougherty TJ (1987) Photodynamic therapy for palliation of locally recurrent breast carcinoma. J Clin Oncol 5: 1766–1770.

    PubMed  CAS  Google Scholar 

  129. Schultz EW, Krueger AP (1930) Inactivation of staphylococcus bacteriophage by methylene blue. Proc Soc Exp Biol Med 26:100–101.

    Google Scholar 

  130. Schwartz SK, Absolon K, Vermund H (1955) Some relationships of porphyrins, x-rays and tumours. Univ Minn Med Bull 27:7–8.

    Google Scholar 

  131. Schweitzer VG, Visscher D (1990) Photodynamic therapy for treatment of AIDS-related oral Kaposi’s sarcoma. Otolaryngol Head Neck Surg 102:639–649.

    PubMed  CAS  Google Scholar 

  132. Shumaker BP, Hetzel FW (1987) Clinical laser photodynamic therapy in the treatment of bladder carcinoma. Photochem Photobiol 46:899–901.

    Article  PubMed  CAS  Google Scholar 

  133. Silver H (1937) Psoriasis vulgaris treated with hematoporphyrin. Arch Dermatol Syph 36:1118–1119.

    Google Scholar 

  134. Sperduto PW, DeLaney TF, Thomas G et al. (1991) Photodynamic therapy for chest wall recurrence in breast cancer. Int J Radiat Oncol Biol Phys 21:441–446.

    Article  PubMed  CAS  Google Scholar 

  135. Star WM, Marijnissen HP, van den Berg Blok AE, Versteeg JA, Franken KA, Reinhold HS (1986) Destruction of rat mammary tumor and normal tissue microcirculation by hematoporphyrin derivative photoradiation observed in vivo in sandwich observation chambers. Cancer Res 46:2532–2540.

    PubMed  CAS  Google Scholar 

  136. Stern R, Zierler S, Parrish JA (1982) Psoriasis and the risk of cancer. J Invest Dermatol 78:147–149.

    Article  PubMed  CAS  Google Scholar 

  137. Svanberg K, Andersson T, Killander D et al. (1994) Photodynamic therapy of non-melanoma malignant tumours of the skin using topical δ-amino levulinic acid sensitization and laser irradiation. Br J Dermatol 130:743–751.

    Article  PubMed  CAS  Google Scholar 

  138. Szeimies RM, Landthaler M (1993) Treatment of Bowen’s disease with topical photodynamic therapy. J Dermatol Treat 4:207–209.

    Article  Google Scholar 

  139. Szeimies RM, Landthaler M (1995) Topische photodynamische Therapie in der Behandlung oberflächlicher Hauttumoren. Hautarzt 46:315–318.

    Article  PubMed  CAS  Google Scholar 

  140. Szeimies RM, Hein R, Bäumler W, Heine A, Landthaler M (1994) A possible new incoherent lamp for photodynamic treatment of superficial skin lesions. Acta Derm Venereol (Stockh) 74:117–119.

    CAS  Google Scholar 

  141. Szeimies RM, Sassy T, Landthaler M (1994) Penetration potency of topical applied δ-aminolevulinic acid for photodynamic therapy of basal cell carcinoma. Photochem Photobiol 59:73–76.

    Article  PubMed  CAS  Google Scholar 

  142. Szeimies RM, Abels C, Fritsch C et al. (1995) Wavelength dependency of photodynamic effects after sensitization with 5-aminolevulinic acid in vitro and in vivo. J Invest Dermatol 105:672–677.

    Article  PubMed  CAS  Google Scholar 

  143. Szeimies RM, Karrer S, Heine A, Hohenleutner U, Landthaler M (1995) Topical photodynamic therapy with 5-aminolevulinic acid in the treatment of arsenic-induced skin tumors. Eur J Dermatol 5:208–211.

    Article  Google Scholar 

  144. Szeimies RM, Karrer S, Abels C et al. (1996) 9-Acetoxy-2,7,12,17-tetrakis(β-methoxy-ethyl)-porphycene (ATMPn), a novel photosensitizer for photodynamic therapy: uptake kinetics and intracellular localization. J Photochem Photobiol B: Biol 43:67–72.

    Article  Google Scholar 

  145. Szeimies RM, Karrer S, Sauerwald A, Landthaler M (1996b) Topical photodynamic therapy with 5-aminolevulinic acid in the treatment of actinic keratoses: a first clinical study. Dermatology 192:246–251.

    Article  PubMed  CAS  Google Scholar 

  146. Tappeiner H v, Jesionek A (1903) Therapeutische Versuche mit fluorescierenden Stoffen. Münch Med Wochenschr 47:2042–2044.

    Google Scholar 

  147. Tappeiner H v, Jodlbauer A (1904) Über die Wirkung der photodynamischen (fluorescierenden) Stoffe auf Protozoen und Enzyme. Dtsch Arch Klin Med 80:427–487.

    Google Scholar 

  148. Thiele B, Grotmann P, Hüttmann G, Diddens H, Hörauf H (1994) Topische photodynamische Therapie (TPDT) von Basaliomen: Klinische, histologische und experimentelle Ergebnisse (erste Mitteilung). Z Hautkr 3:161–164.

    Google Scholar 

  149. Tse DT, Kersten RD, Anderson RL (1984) Hematoporphyrin derivative photoradiation therapy in managing nevoid basal cell carcinoma syndrome. Arch Ophthalmol 102:990–994.

    PubMed  CAS  Google Scholar 

  150. Vogel E, Köcher M, Schmickler H, Lex J (1986) Porphycene — a novel porphin isomer. Angew Chem 98:262–264.

    Article  CAS  Google Scholar 

  151. Waldow SM, Lobraico RV, Kohler IK, Wallk S, Fritts HT (1987) Photodynamic therapy for treatment of malignant cutaneous lesions. Lasers Surg Med 7:451–456.

    Article  PubMed  CAS  Google Scholar 

  152. Warloe T, Peng Q, Moan J, Qvist HL, Giercksky KE (1992) Photochemotherapy of multiple basal cell carcinoma with endogenous porphyrins induced by topical application of 5-aminolevulinic acid. In: Spinelli P, Dal Fante M, Marchesini R (eds) Photodynamic therapy and biomedical lasers. Elsevier, Amsterdam, pp 449–453.

    Google Scholar 

  153. Weinstein GD, McCullough JL, Nelson JS, Berns MW, McCormick AJ (1991) Low-dose photofrin II photodynamic therapy of psoriasis. Clin Res 39:509A (abstr).

    Google Scholar 

  154. Weinstein GD, McCullough JL, Jeffes EW, Nelson JS, Fong NL, McCormick AJ (1994) Photodynamic therapy (PDT) of psoriasis with topical delta amnolevulinic acid (ALA): A pilot dose ranging study. Photodermatol Photoimmunol Photomed 10:92 (abstr).

    Google Scholar 

  155. Weishaupt KR, Gomer CJ, Dougherty TJ (1976) Identification of singlet oxygen as the cytotoxic agent in photo-inactivation of a murine tumor. Cancer Res 36:2326–2329.

    PubMed  CAS  Google Scholar 

  156. Wessels JM, Strauss W, Seidlitz HK, Rück A, Schneckenburger H (1992) Intracellular localization of meso-tetraphenylporphine tetrasulphonate probed by time-resolved and microscopic fluorescence spectroscopy. J Photochem Photobiol B: Biol 12:275–284.

    Article  CAS  Google Scholar 

  157. Wilson BD, Mang TS, Cooper M, Stoll H (1989) Use of photodynamic therapy for the treatment of extensive basal cell carcinomas. Facial Plast Surg 6:185–189.

    Article  PubMed  CAS  Google Scholar 

  158. Wilson BD, Mang TS, Stoll H, Jones C, Cooper M, Dougherty TJ (1992) Photodynamic therapy for the treatment of basal cell carcinoma. Arch Dermatol 128:1597–1601.

    Article  PubMed  CAS  Google Scholar 

  159. Winkelman JW, Collins GH (1987) Neurotoxicity of tetraphenylporphinesulfonate TPPS4 and its relation to photodynamic therapy. Photochem-Photobiol 46:801–807.

    Article  PubMed  CAS  Google Scholar 

  160. Wolf P, Kerl H (1995) Photodynamic therapy with 5-aminolevulinic acid: a promising concept for the treatment of cutaneous tumors. Dermatology 190:183–185.

    Article  PubMed  CAS  Google Scholar 

  161. Wolf P, Rieger E, Kerl H (1993) Topical photodynamic therapy with endogenous porphyrins after application of 5-aminolevulinic acid. J Am Acad Dermatol 28:17–21.

    Article  PubMed  CAS  Google Scholar 

  162. Wolf P, Fink-Puches R, Cerroni L, Kerl H (1994) Photodynamic therapy for mycosis fungoides after topical photosensitization with 5-aminolevulinic acid. J Am Acad Dermatol 31:678–680.

    Article  PubMed  CAS  Google Scholar 

  163. Wolf P, Fink-Puches R, Kerl H (1995) Photodynamic therapy for mycosis fungoides after topical photosensitization with 5-aminolevulinic acid. J Am Acad Dermatol 33:541.

    Article  Google Scholar 

  164. Wolford ST, Novicki DL, Kelly B (1995) Comparative skin phototoxicity in mice with two photosensitizing drugs: Benzoporphyrin derivative monoacid ring A and porfimer sodium (Photofrin). Fundam Appi Toxicol 24:52–56.

    Article  CAS  Google Scholar 

  165. Woodburn KW, Vardaxis NJ, Hill JS, Kaye AH, Phillips DR (1991) Subcellular localization of porphyrins using confocal laser scanning microscopy. Photochem Photobiol 54:725–732.

    Article  PubMed  CAS  Google Scholar 

  166. Wooten RS, Smith KC, Ahlquist DA, Muller SA, Balm RK (1988) Prospective study of cutaneous phototoxicity after systemic hematoporphyrin derivative. Lasers Surg Med 8:294–300.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Rolf-Markus Szeimies
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  2. Christoph Abels
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  3. Wolfgang Bäumler
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  4. Sigrid Karrer
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  5. Michael Landthaler
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Editors and Affiliations

  1. Hautklinik, Heinrich-Heine-Universität, Moorenstraße 5, D-40225, Düsseldorf, Germany

    Jean Krutmann

  2. Universitätsklinik für Dermatologie, Allgemeines Krankenhaus der Stadt Wien, Währinger Gürtel 18-20, A-1090, Wien, Germany

    Herbert Hönigsmann

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Szeimies, RM., Abels, C., Bäumler, W., Karrer, S., Landthaler, M. (1997). Photodynamische Therapie in der Dermatologie. In: Krutmann, J., Hönigsmann, H. (eds) Handbuch der dermatologischen Phototherapie und Photodiagnostik. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60425-6_11

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  • DOI: https://doi.org/10.1007/978-3-642-60425-6_11

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