Abstract
Farmer’s lung is a frequent form of extrinsic allergic alveolitis that is induced by inhalation of antigens found in mouldy hay. We have previously shown that in patients with acute episodes of farmer’s lung circulating neutrophils are primed for an enhanced respiratory burst [1]. To further characterize the alveolitis in acute episodes of farmer’s lung, we measured cytokine and endotoxin levels in the bronchoalveolar lavage (BAL) fluid of farmer’s lung patients after inhalative provocation and analysed the expression of leukocyte activation markers and adhesion molecules on both blood and BAL cells pre- and post-exposure.
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References
Vogelmeier C, Krombach F, Münzing S, König G, Fruhmann G. Activation of blood neutrophils in acute episodes of farmer’s lung. Am Rev Respir Dis 148:396–400, 1993
Padovan C, Behr J, Allmeling A-M, Gerlach T, Vogelmeier C, Krombach F. Immunophenotyping of lymphocyte subpopulations in bronchoalveolar lavage fluid. Comparison of flow cytometric and immunocytochemical techniques. J Immunol Methods 147:27–32, 1992
Krombach F, Gerlach JT, Padovan C, Burges A, Behr J, Vogelmeier C. Characterization and quantification of alveolar monocyte-like cells in chronic inflammatory lung disease. Eur Respir J 9:984–991, 1996
Lehr H-A, Krombach F, Münzing S, Bodlaj R, Glaubitt SI, Seiffge D, Hübner C, von Andrian UH, Messmer K. In vitro effects of oxidized LDL on CDllb/CD18 and L-selectin presentation on neu¬trophils and monocytes with relevance for the in vivo situation. Am J Pathol 146:218–227, 1995
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© 1997 Springer-Verlag Berlin Heidelberg
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Krombach, F., Mazur, G., Beinert, T., Vogelmeier, C. (1997). Characterization of the Alveolitis in Patients with Acute Episodes of Farmer’s Lung. In: Ring, J., Behrendt, H., Vieluf, D. (eds) New Trends in Allergy IV. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60419-5_43
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DOI: https://doi.org/10.1007/978-3-642-60419-5_43
Publisher Name: Springer, Berlin, Heidelberg
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