Abstract
An effective skin barrier in mammalian epidermis is essential for survival since without the maintenance of the permeability barrier, human skin would evaporate most of its body moisture within a short period of time [4, 37, 38].
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Abraham W, Wertz PW, Landmann L, Downing DT (1987) O-acylglucosylceramides and o-acyl- ceramides cause aggregation and stacking of stratum corneum lipid liposomes. J Invest Derm 88: 474
Bartelt RN, Chilf GN (1984) Fortschritte in der Therapie des endogenen Ekzems durch einen neuen UVA Strahler. Dt Derm 32: 495–503
Defend D, Saint Leger D, Leveque JL, Agache P (1986) In vivo measurement of epidermal lipids in man. Bioeng Skin 2: 71–85
Elias PM, Friend DS (1975) The permeability barrier in mammalian epidermis. J Cell Biol 65: 180–191
Elias PM, Goerke J, Friend DS (1977) Mammalian epidermal barrier layer lipids: composition and influence on structure. J Invest Dermatol 69: 535–546
Elias PM, Brown BE, Fritsch P, Goerke J, Gray GM, White RJ (1979) Localization and composition of lipids in neonatal mouse stratum granulosum and stratum corneum. J Invest Dermatol 73: 339–348
Elias PM, Brown BE, Ziboh VA (1980) The permeability barrier in essential fatty acid deficiency: evidence for a direct role for linoleic acid in barrier function. J Invest Dermatol 74: 230–233
Elias PM (1981) Epidermal lipids, membranes, and keratinization. Int J Dermatol 20: 1–19
Elias PM (1981) Lipids and the epidermal permeability barrier. Arch Derm Res 270: 95–117
Elias PM, Cooper ER, Kore A, Brown BE (1981) Percutaneous transport in relation to stratum corneum structure and lipid composition. J Invest Dermatol 76: 297–301
Elias PM (1983) Epidermal lipids, barrier function, and desquamation. J Invest Derm 80S: 44–49
Elias PM (1988) Structure and function of the stratum corneum permeability barrier. Drue Dev Res 13: 97–105
Elias PM, Menon GK, Grayson S, Brown BE (1988) Membrane structural alterations in murine stratum corneum: relationship to the localization of polar lipids and phospholipases. J Invest Dermatol 91: 3–10
Elias PM, Holleran WM, Menon GK, Ghadially R, Williams ML, Feingold KR (1993) Normal mechanisms and pathophysiology of epidermal permeability barrier homeostasis. Curr Opin Derm 1: 231–237
Fartasch M, Bassukas ID, Diepgen TL (1992) Disturbed extruding mechanism of lamellar bodies in dry non-eczematous skin of atopics. Br J Derm 127: 221–227
Hanifin JM, Rajka G (1980) Diagnostic features of atopic dermatitis. Acta Derm Venerol (Stockh) 92S: 44–47
Hannun YA, Obeid LM (1995) Ceramide: an intracellular signal for apoptosis. TIBS 20: 73–77
Imokawa G, Hattori M (1985) A possible function of structural lipids in the water-holding prop¬erties of the stratum corneum. J Invest Dermatol 84: 282–284
Imokawa G, Akasaki S, Hattori M, Yoshizuka N (1986) Selective recovery of deranged water-holding properties by stratum corneum lipids. J Invest Dermatol 87: 758–761
Imokawa G, Akasaki S, Minematsu Y, Kawai M (1989) Importance of intercellular lipids in water- retention properties of the stratum corneum: induction and recovery study of surfactant dry skin. Arch Derm Res 281: 45–51
Imokawa G, Abe A, Jin K, Higaki Y, Kawashima M, Hidano A (1991) Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J Invest Dermatol 96: 523–526
Jin K, Higaki Y, Takagi Y, Higuchi K, Yada Y, Kawashima M, Imokawa G (1994) Analysis of beta- glucocerebrosidase and ceramidase activities in atopic and aged dry skin. Acta Derm Venerol (Stockh) 74: 337–340
Kay J, Gawkrodger DJ, Mortimer MJ, Jaron AG (1994) The prevelance of childhood atopic eczema in a general population. J Am Acad Dermatol 30: 35–39
Kowalzick L, Kleinheinz A, Weichenthal M, Neuber K, Köhler I, Grosch J, Lungwitz G, Seegeberg C, Ring J (1995) Low dose versus medium dose UV Al treatment in severe atopic eczema. Acta Derm Venerol (Stockh) 75: 43–45
Krutmann J, Czech W, Diepgen T, Niedner R, Kapp A, Schöpf E (1992) High-dose UVA 1 therapy in the treatment of patients with atopic dermatitis. J Am Acad Dermatol 26: 225–230
Lavrijsen APM, Higounenc IM, Weerheim A, Oestmann E, Tuinenburg EE, Boddé HE, Ponec M (1994) Validation of an in vivo extraction method for human stratum corneum ceramides. Arch Derm Res 286: 495–503
Long SA, Wertz PW, Strauss JS, Downing DT (1985) Human stratum corneum polar lipids and desquamation. Arch Dermatol Res 277: 284–287
Meffert H, Sönnichsen N, Herzog M, Hutschenreuther A (1992) UVA 1 Kaltlichttherapie des akut exazerbierten, schweren atopischen Ekzems. Dermatol Monatsschr 178: 291–296
Melnik B, Hollmann J, Plewig G (1988) Decreased stratum corneum ceramides in atopic individuals–a pathobiochemical factor in xerosis? Br J Dermatol 119: 547–549
Melnik BC, Hollmann J, Erler E, Verhoeven B, Plewig G (1989) Microanalytical screening of all major stratum corneum lipids by sequential high-performance thin-layer chromatography. J Invest Dermatol 92: 231–234
Melnik B, Hollmann J, Hofmann U, Yuh MS, Plewig G (1990) Lipid composition of outer stratum corneum and nails in atopic and control subjects. Arch Dermatol Res 282: 549–551
Melnik BC (1990) Disturbances of epidermal lipid metabolism and barrier function in atopic eczema. In: Ruzicka T, Ring J, Przybilla B (eds) Handbook of atopic eczema. Springer Verlag, Berlin, Heidelberg, New York, pp 296–305
Menon GK, Grayson S, Elias PM (1986) Cytochemical and biochemical localization of lipase and sphingomyelinase activity in mammalian epidermis. J Invest Dermatol 86: 591–597
Pushkareva M, Obeid LM, Hannun YA (1995) Ceramide: an endogenous regulator of apoptosis and growth suppression. Immunology Today 16: 294–297
Saint Léger D, Francois AM, Lévêque JL, Stoudemayer TJ, Grove GL, Kligman AM (1988) Age- associated changes in stratum corneum lipids and their relation to dryness. Dermatologica 177: 159–564
Schäfer L, Kragballe K (1991) Abnormalities in epidermal lipid metabolism in patients with atopic dermatitis. J Invest Dermatol 96: 10–15
Schürer NY, Plewig G, Elias PM (1991) Stratum corneum lipid function. Dermatologica 183: 77–94
Schürer NY, Elias PM (1991) The biochemistry and function of stratum corneum lipids. Adv Lipid Res 24: 27–56
Tupker RA, Pinnagoda J, Coenraads PJ, Nater JP (1990) Susceptibility to irritants: role of barrier function, skin dryness and history of atopic dermatitis. Br J Dermatol 123: 199–205
Wakita H, Tokura Y, Yagi H, Nishimura K, Furukawa F, Takigawa M (1994) Keratinocyte differentiation is induced by cell-permeant ceramides and its proliferation is promoted by sphingosine. Arch Derm Res 286: 350–354
Wefers H, Melnik BC, Flür M, Bluhm C, Lehmann P, Plewig G (1991) Influence of UV radiation on the composition of human stratum corneum lipids. J Invest Dermatol 96: 959–562
Werner Y, Lindberg M (1985) Transepidermal water loss in dry and clinically normal skin in patients with atopic dermatitis. Acta Derm Venerol (Stockh) 65: 102–105
Werner Y, Lindberg M, Forlind B (1987) Membrane-coating granules in “dry” non-eczematous skin of patients with atopic dermatitis. Acta Derm Venerol (Stockh) 67: 385–390
Wertz PW, Downing DT (1982) Glycolipids in mammalian epidermis: structure and function in the water barrier. Science 217: 1261–1262
Williams ML, Elias PM (1993) From basket weave to barrier. Arch Dermatol 129: 626–629
Yamamoto A, Serizawa S, Ito M, Sato Y (1991) Stratum corneum lipid abnormalities in atopic dermatitis. Arch Dermatol Res 283: 219–223
Yardley HJ (1987) Epidermal lipids. Int J Cosm Sci 9: 13–19
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Abeck, D., Bleck, O., Ring, J. (1997). Skin Barrier and Eczema. In: Ring, J., Behrendt, H., Vieluf, D. (eds) New Trends in Allergy IV. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60419-5_33
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DOI: https://doi.org/10.1007/978-3-642-60419-5_33
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