Skip to main content
SpringerLink
Log in

T Lymphocytes and Subpopulations: Involvement of TH2 Cells in Allergic Diseases

  • Conference paper
New Trends in Allergy IV

  • 119 Accesses

Abstract

In recent years a large body of evidence has been accumulated in demonstrating that TH2 cells play a central role in the pathogenesis of allergic diseases. Allergen-specific TH2 cells can be isolated at the site of allergic phlogosis and their cytokines are responsible both for the induction of IgE production by B cells and the activation and recruitment of eosinophils, mast cells and basophils, which represent the major cellular components of allergic inflammation. The development of TH2 cells is favoured by the presence of interleukin-4 (IL-4) at the time of antigen presentation or by hormones, such as progesterone. On the other hand, other cytokines (IL-12, interferon- α and γ, transforming growth factor-β) play a negative regulatory role. More recently a preferential membrane expression of CD30 has been demonstrated in TH2 cells and an increase in the amount of the soluble form of this receptor is detectable in some TH2-mediated pathological conditions.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Mosmann TR, Chervinsky H, Bond MW, Giedlin MA, Coffman RL: Two types of murine helper T-cell clone. U. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136: 2348–2357, 1986

    PubMed  CAS  Google Scholar 

  2. Del Prete GF, De Carli M, Mastromauro C, Macchia D, Biagiotti R, Ricci M, Romagnani S: Purified Protein Derivative of Mycobacterium Tuberculosis and Excretory-Secretory Antigen(s) of Toxo¬cara Canis Expand in Vitro Human T Cells with Stable and Opposite (Type 1 T Helper or Type 2 T Helper) Profile of Cytokine Production. J Clin Invest 88: 346–350, 1991

    Article  PubMed  Google Scholar 

  3. Parronchi P, Macchia D, Piccinni M-P, Biswas P, Simonelli C, Maggi E, Ricci M, Ansari AA, Romagnani S: Allergen- and Bacterial Antigen-specific T-cell Clones Established from atopic Donors Show a Different Profile of Cytokine Production. Proc Natl Acad Sci USA 88: 4538–4542, 1991

    Article  PubMed  CAS  Google Scholar 

  4. Romagnani S: Human TH1 and TH2: Doubt no more. Immunol Today 12: 256–257, 1992

    Article  Google Scholar 

  5. Maggi E, Biswas P, Del Prete GF, Parronchi P, Macchia D, Simonelli C, Emmi L, De Carli M, Tiri A, Ricci M, Romagnani S: Accumulation of TH2-like Helper T Cells in the Conjunctiva of Patients with Vernal Conjunctivitis. J Immunol 146: 1169–1174, 1991

    PubMed  CAS  Google Scholar 

  6. Hamid Q, Azzawi M, Ying S, Moqbel R, Wardaw AJ, Corrigan CJ, Bradley B, Durham SR, Collins JV, Jeffery PK, Quint DJ, Kay AB: Expression of mRNA for Interleukin-5 in Mucosal Bronchial Biopsies from asthma. J Clin Invest 87: 1541–1546, 1991

    Article  PubMed  CAS  Google Scholar 

  7. Robinson DS, Hamid Q, Ying S, Tsicopoulos A, Barkans J, Bentley AM, Corrigan CJ, Durham SR, Kay AB: Predominant TH2-like Bronchoalveolar T-lymphocyte Population in Atopic Asthma. New Engl J Med 326: 295–304, 1992

    Article  Google Scholar 

  8. Del Prete GF, De Carli M, D’Elios MM, Maestrelli P, Ricci M, Fabbri L, Romagnani S: Allergen Exposure Induces the Activation of Allergen-Specific TH2 Cells in the Airway Mucosa of Patients with Allergic Respiratory Disorders. Eur J Immunol 23: 1445–1449, 1993

    Article  PubMed  Google Scholar 

  9. van Reijsen FC, Bruijnzeel-Koomen CAFM, Kalthoff FS, Maggi E, Romagnani S, Westland JKT, Mudde GC: Skin-derived Aeroallergen-specifìc T-cell Clones of TH2 Phenotype in Patients with Atopic Dermatitis. J Allergy Clin Immunol 90: 184–192, 1992

    Article  PubMed  Google Scholar 

  10. Seder RA, Paul WE, Davis MM, Fazekas de St Groth B: The presence of interleukin 4 during in vitro priming determines the lymphocyte-producing potential of CD4+ T cells from T cell re¬ceptor transgenic mice. J Exp Med 1992, 176: 1091–1098

    Article  PubMed  CAS  Google Scholar 

  11. Daynes RA, Meikle AW, Araneo BA: Locally Active Steroid Hormones May Facilitate Compart- mentalzation of Immunity by Regulating the Types of Lymphokines Produced by Helper T Cells. Res Immunol 1991, 142: 40–44

    Article  PubMed  CAS  Google Scholar 

  12. Hsieh C-S, Macatonia SE, Tripp CS, Wolf SF, O’Garra A, Murphy KM: Development of TH1 CD4+ T Cells through IL-12 Produced by Leisteria–Induced Macrophages. Science 260: 547–549, 1993

    Article  PubMed  CAS  Google Scholar 

  13. Romagnani S: Induction of TH1 and TH2 Response: a Key Role for the “Natural” Immune Response? Immunol Today 13: 379–380, 1992

    Google Scholar 

  14. Maggi E, Parronchi P, Manetti R, Simonelli C, Piccinni MP, Santoni-Rugiu F, De Carli M, Ricci M, Romagnani S: Reciprocal regulatory role of IFN-y and IL-4 on the in vitro development of TH1 and TH2 clones. J Immunol 148: 2142–2147, 1992

    PubMed  CAS  Google Scholar 

  15. Parronchi P, De Carli M, Manetti R, Simonelli C, Sampognaro S, Piccinni MP, Macchia D, Maggi E, Del Prete GF, Romagnani S: IL-4 and IFNs (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by TH1 or TH2 human T cell clones. J Immunol 149: 2977–2984, 1992

    PubMed  CAS  Google Scholar 

  16. Manetti R, Barak V, Piccinni M-P, Sampognaro S, Parronchi P, Maggi E, Dinarello CA, Romagnani S: Interleukin 1 Favors the in Vitro Development of Type 2 Helper (TH2) Human T Cell Clones. Res Immunol 145: 93–100, 1994

    Article  PubMed  CAS  Google Scholar 

  17. Manetti R, Parronchi P, Giudizi M-G, Piccinni M-P, Maggi E, Trinchieri G, Romagnani S: Natural Killer Cell Simulatory Factor (Interleukin 12) Induces T Helper Type 1 (TH1)-Specific Immune Responses and Inhibits the Development of IL-4-Producing Th Cells. J Exp Med 177: 1199–1204, 1993

    Article  PubMed  CAS  Google Scholar 

  18. Manetti R, Gerosa F, Giudizi M-G, Biagiotti R, Parronchi P, Piccinni M-P, Sampognaro S, Maggi E, Romagnani S, Trinchieri G: Interleukin-12 Induces Stable Priming for Interferon-y) Production during Differentiation of Human T Helper (Th) Cells and Transient IFN-y Production in Estab¬lished TH2 Cell Clones. J Exp Med 179: 1273–1283, 1994

    Article  PubMed  CAS  Google Scholar 

  19. De Carli M, Berthold S, Fickenscher H, Fleckenstein IM, D’Elios MM, Gao Q, Biagiotti R, Giudizi MD, Kalden JR, Fleckenstein B, Romagnani S, Del Preter GF: Immortalization with herpes virus saimiri modulates the cytokine secretion profile of established TH1 and TH2 human T cell clones. J Immunol 151: 5022–5030, 1993

    PubMed  Google Scholar 

  20. Secrist H, Chelen CJ, Wen Y, Marshall JD, Umetsu DT: Allergen immunotherapy decreases inter¬leukin 4 production in CD4+ cells from allergic individuals. J Exp Med 178: 2123–2130, 1993

    Article  PubMed  CAS  Google Scholar 

  21. Del Prete GF, De Carli M, Almerigogna F, Daniel CK, D’Elios MM, Zancuoghi G, Vinante F, Pizzolo G, Romagnani S: Preferential Expression of CD30 by Human CD4+ T Cells Producting TH2-type Cytokines. FASEB J, 1995

    Google Scholar 

  22. Manetti R, Annunziato F, Biagiotti R, Giudizi MG, Piccinni MP, Giannarini L, Sampognaro S, Parronchi P, Vinante F, Pizzolo G, Maggi E, Romagnani S: CD30 expression by CD8+ T cells producing TH2-type cytokines. Evidence for large numbers of CD8+ CD30+ T cell clones in human immunodeficiency virus (HIV) infection. J Exp Med 180, 1994

    Google Scholar 

  23. Romagnani S, Del Prete GF, Maggi E, Chilosi M, Caligaris-Cappio F, Pizzolo G. CD30 and type 2 T helper (TH2) responses. In press

    Google Scholar 

Download references

Authors
  1. P. Parronchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Maggi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Manetti
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. P. Piccinni
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. Sampognaro
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. Annunziato
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. L. Giannarini
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. L. Beloni
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. S. Romagnani
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Klinik and Poliklinik für Dermatologie und Allergologie am Biederstein, Technische Universität München, Biedersteiner Str. 29, 80802, München, Germany

    Johannes Ring

  2. Abt. Experimentelle Dermatologie und Allergologie, Universitäts-Krankenhaus Eppendorf, Martinistraße 53, 20246, Hamburg, Germany

    Heidrun Behrendt

  3. Hautklinik/Allergieabteilung, Universitäts-Krankenhaus Eppendorf, Martinistraße 53, 20246, Hamburg, Germany

    Dieter Vieluf

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Parronchi, P. et al. (1997). T Lymphocytes and Subpopulations: Involvement of TH2 Cells in Allergic Diseases. In: Ring, J., Behrendt, H., Vieluf, D. (eds) New Trends in Allergy IV. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60419-5_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-60419-5_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64398-9

  • Online ISBN: 978-3-642-60419-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation