Abstract
Inhalation of the ubiquitous air pollutant ozone results in airway inflammation and impairs respiratory functions. Because alveolar phagocytes are known to play an important role in lung responses to pulmonary irritants through alterations in capacity of phagocytizing particles, liberate cytokines or migrate in the alveoli, we investigated the influence of ozone on the cytokine release by bovine (BAM) and human (HAM) alveolar macrophages as well as by macrophage-like HL-60 cells.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Arts RM, Christian D, Heame PQ, Kern K, Finkbeiner WE, Balmes JR: Ozone-induced Airway In-flammation in Human Subjects as Determined by Airway Lavage and Biopsy. Am Rev Respir Dis 148, 1363–1372, 1993
Donaldson K, Brown GM, Brown DM, Slight J, Li XY: Epithelial and Extracellular Matrix Injury in Quartz-Inflamed Lung: Role of the Alveolar Macrophage. Environ Health Perspect 97, 221–224, 1992
Mosbach M: In vitro-Untersuchungen zum Einfluß von Ozon auf Immunfunktionen von Alveolarmalcrophagen. Report of Kernforschungszentrum Karlsruhe, KfK 5443 B, 1994
Polzer G, Lind I, Mosbach M, Schmidt A, Seidel A: Combined Influence of Quartz Dust, Ozone and NO2 on Chemotactic Mobility, Release of Chemotactic Factors and other Cytokines by Macrophages in vitro. Toxicol Lett 72, 307–315, 1994
Schultheis AH, Bassett DJP: Guinea Pig Lung Inflammatory Cell Changes Following Acute Ozone Exposure. Lung 172, 169–181, 1994
Shiotsuka RN, Yermakoff JK, Osheroff MR, Drew RT: The Combination of Ozone and Silica on the Development of Pulmonary Fibrosis. J Toxicol Environ Health 17, 297–310, 1986
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Mosbach, M., Wiener-Schmuck, M., Seidel, A. (1997). Influence of Particles and Surfactant on the In Vitro Response of Macrophages to Ozone. In: Ring, J., Behrendt, H., Vieluf, D. (eds) New Trends in Allergy IV. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60419-5_13
Download citation
DOI: https://doi.org/10.1007/978-3-642-60419-5_13
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-64398-9
Online ISBN: 978-3-642-60419-5
eBook Packages: Springer Book Archive